Leicester Medical School Understanding frailty - Kavli Senter
Leicester Medical School Understanding frailty - Kavli Senter
Leicester Medical School Understanding frailty - Kavli Senter
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Genetics<br />
• Few studies have looked at genetic determinants of <strong>frailty</strong><br />
• Multiple genes known to affect ageing or single or multiple<br />
domains of <strong>frailty</strong><br />
– DNA methylation/folate<br />
– Insulin/IGF1<br />
– Vitamin D<br />
– WRN helicase and lamin A (premature ageing)<br />
– Sirtuin genes<br />
– Antioxidants (superoxide dismutase, glutathione peroxidases)<br />
– Cardiovascular modifiers e.g. NO, RAS<br />
– Neurocognitive ageing e.g. ApoE<br />
• May identify pathways amenable to intervention
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