Leicester Medical School Understanding frailty - Kavli Senter
Leicester Medical School Understanding frailty - Kavli Senter
Leicester Medical School Understanding frailty - Kavli Senter
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Oxidative stress<br />
• Reactive oxygen species (ROS) damage to<br />
DNA, proteins and lipid within ageing muscle<br />
cells → sarcopaenia<br />
• ROS levels associated with low grip strength<br />
& mortality<br />
• Candidate modifiable risk factors<br />
– smoking<br />
– dietary intake of carotenoids, ascorbate, selenium,<br />
plant polyphenols<br />
– exercise
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