Transcriptional regulation of meiosis in budding yeast

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I. Introduction II. Transcriptional cascade governs initiation of meiosis. III. Transcriptional regulation of IME1. A. The MAT signal 1. Genes whose products transmit the MAT signal to IME1 and meiosis 1.1. RME1. 1.2. IME4. 1.3. RES1. B. The nitrogen signal C. The glucose Signal 1. The cAMP signal-transduction pathway. 1.1. The IREu element. 1.1.1. Msn2 and Msn4. 1.1.2. Sok2. 1.2. Rim15 2. The Snf1 signal-transduction pathway 3. Respiration and the transcription of IME1. D. Additional proteins regulating the transcription of IME1 1. Mck1 2. Tup1/Ssn6 3. Yhp1 4. The Swi/Snf chromatin remodeling complex E. Positive and negative feedback regulation. F. Summary. IV. Transcriptional regulation of early meiosis-specific genes A. Silencing of early meiosis-specific genes in vegetative growth. 1. The WTM genes. 2. The UME2 gene. 3. The UME3 and UME5 genes. 4. The SIN3, UME6, and RPD3 genes. 5. The ISW2 gene. B. Expression of early meiosis-specific genes under meiotic conditions. 1. Ume6 is also positive regulator. 2. The function of Ime1. 1
3. Proteins required for the association of Ime1 with Ume6. 3.1. The function of Rim11 and its homologs Mck1 and Mrk1. 3.2. The function of Rim15. 4. The function of Gcn5. 5. The transcription of early meiosis-specific genes is also regulated by positive elements. 6. Additional positive regulators. 7. The role of premeiotic DNA replication and/or recombination in controlling early meiosis-specific genes expression. 8. The choice between silencing and expression of early meiosis-specific genes. V. Transcriptional regulation of middle meiosis-specific genes A. Positive regulators of middle meiosis-specific genes 1. Ndt80 2. Ime2 3. Sin3 and Rpd3 B. Negative regulators of middle meiosis-specific genes C. The recombination checkpoint VI. Transcriptional regulation of late meiosis-specific genes A. Early late genes. B. Mid late genes C. Late genes VII. A feedback loop controlling meiosis. VIII. Concluding remark. The choice between developmental pathways 2
Page 1: Transcriptional regulation of meios
Page 5 and 6: I. Introduction The budding yeast S
Page 7 and 8: et al., 2000). On the other hand, i
Page 9 and 10: the UCS4 element upstream of the CY
Page 11 and 12: egulator of Cyr1, CDC25 encodes the
Page 13 and 14: 1998). Furthermore, unlike IREu, IR
Page 15 and 16: In the absence of glucose Sok2 does
Page 17 and 18: autophosphorylation, including on a
Page 19 and 20: hours in SPM, followed by a decline
Page 21 and 22: 4. The SIN3, UME6, and RPD3 genes.
Page 23 and 24: 1993). Nevertheless, when Ime1 is t
Page 25 and 26: However, direct demonstration of ph
Page 27 and 28: 3. Proteins required for the associ
Page 29 and 30: heterologous promoter does not supp
Page 31 and 32: expressed only in the absence of gl
Page 33 and 34: structure of hCDK2 reveals that cyc
Page 35 and 36: terminal non-essential domain (Komi
Page 37 and 38: is dependent on Ime2, but in cells
Page 39 and 40: VI. Transcriptional regulation of l
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Page 43 and 44: Functional interaction between Ime1
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Pazin, M. J., and Kadonaga, J. T. (
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Shenhar, G. (2001). TRANSCRIPTIONAL
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Szent-Gyorgyi, C. (1995). A biparti
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Yoshida, M., Kawaguchi, H., Sakata,
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Fig. 4. The function of positive an
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Fig. 9. A schematic structure of IM
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activation by Ime2 is due to phosph
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MCK1 Protein kinase required for ef
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UME3 A cyclin C homolog that associ
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