Transcriptional regulation of meiosis in budding yeast
Transcriptional regulation of meiosis in budding yeast
Transcriptional regulation of meiosis in budding yeast
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I. Introduction<br />
II. <strong>Transcriptional</strong> cascade governs <strong>in</strong>itiation <strong>of</strong> <strong>meiosis</strong>.<br />
III. <strong>Transcriptional</strong> <strong>regulation</strong> <strong>of</strong> IME1.<br />
A. The MAT signal<br />
1. Genes whose products transmit the MAT signal to IME1 and <strong>meiosis</strong><br />
1.1. RME1.<br />
1.2. IME4.<br />
1.3. RES1.<br />
B. The nitrogen signal<br />
C. The glucose Signal<br />
1. The cAMP signal-transduction pathway.<br />
1.1. The IREu element.<br />
1.1.1. Msn2 and Msn4.<br />
1.1.2. Sok2.<br />
1.2. Rim15<br />
2. The Snf1 signal-transduction pathway<br />
3. Respiration and the transcription <strong>of</strong> IME1.<br />
D. Additional prote<strong>in</strong>s regulat<strong>in</strong>g the transcription <strong>of</strong> IME1<br />
1. Mck1<br />
2. Tup1/Ssn6<br />
3. Yhp1<br />
4. The Swi/Snf chromat<strong>in</strong> remodel<strong>in</strong>g complex<br />
E. Positive and negative feedback <strong>regulation</strong>.<br />
F. Summary.<br />
IV. <strong>Transcriptional</strong> <strong>regulation</strong> <strong>of</strong> early <strong>meiosis</strong>-specific genes<br />
A. Silenc<strong>in</strong>g <strong>of</strong> early <strong>meiosis</strong>-specific genes <strong>in</strong> vegetative growth.<br />
1. The WTM genes.<br />
2. The UME2 gene.<br />
3. The UME3 and UME5 genes.<br />
4. The SIN3, UME6, and RPD3 genes.<br />
5. The ISW2 gene.<br />
B. Expression <strong>of</strong> early <strong>meiosis</strong>-specific genes under meiotic conditions.<br />
1. Ume6 is also positive regulator.<br />
2. The function <strong>of</strong> Ime1.<br />
1
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