Christoph Licht - Oxford Journals

BIOGRAPHICAL INFORMATION 

CURRICULUM VITAE 

Name: Christoph Paul Benedikt Licht 

Date of Birth: July 17, 1964 

Office: The Hospital for Sick Children 

Division of Nephrology 

555 University Avenue, Room 5123C, Burton (previously Elm) 

Toronto, Ontario M5G 1X8, Canada 

Office Tel: 416-813-7654, x2058 

Office Fax: 416-813-6271 

Pager: 416-235-7418 

Laboratory: The Hospital for Sick Children 

Research Institute 

Program in Cell Biology 

Room 4025/4027, McMaster 

Toronto, Ontario M5G 1X8, Canada 

Laboratory Tel: 416-813-7654, x28018 

Cell Biology Fax: 416-813-5028 

Hospital Email: christoph.licht@sickkids.ca 

EDUCATION 

Degrees and Diplomas: 

May 11, 1992 M.D. – Albert-Ludwigs-University, Freiburg, Germany 

Jan 19, 1995 Dr. med. (Doctorate in Medicine), Internal Medicine/Nephrology – Ruprecht-Karls- 

University, Heidelberg, Germany 

Thesis Title: PGE2–and electrophysiological measurements of renal collecting duct 

principal cell epithelium. 

(Supervisor: Dr. Peter Gross) 

Nov 16, 2005 Habilitation – University of Cologne, Cologne, Germany 

Thesis Title: Novel aspects of chronic kidney disease. Role of endothelin-1 and 

complement dysregulation. 

Licensures and Certifications: 

Dec-93 Certificate of Approbation as Physician – Stuttgart, Germany 

Aug-98 Board Certification in Pediatrics – Düsseldorf, Germany 

May-06 License in Paediatrics/Paediatric Nephrology – College of Physicians and Surgeons 

of Ontario, Toronto, Ontario 

Updated: August 5, 2011 Page 1 of 35

Dec-06 Board Certification in Pediatric Nephrology – Düsseldorf, Germany 

Specialty Training and Fellowships: 

Jun-92–Jun-98 Postgraduate Training, Pediatrics – Children's Hospital of the University of 

Cologne, Cologne, Germany 

(Supervisor: Dr. Dietrich V. Michalk) 

Jul-98–Jun-99 Clincial Fellowship, Pediatric Nephrology – Children's Hospital of the University 

of Cologne, Cologne, Germany 


Jul-99–Jul-02 Postdoctoral Research Fellowship, Nephrology – University of Texas, 

Southwestern Medical Center at Dallas, Dallas, Texas 

(Supervisors: Drs. Robert J. Alpern, Patricia A. Preisig, and Masashi Yanagisawa) 

Aug-02–Oct-05 Clinical Fellowship, Pediatric Nephrology – Children's Hospital of the University 

of Cologne, Cologne, Germany 


Training Courses: 

May 23, 2009 Inaugural Certificate Program in Translational Medicine, 

Eureka Institute for Translational Medicine, Siracusa, Italy 

EMPLOYMENT 

Academic Appointments: 

Nov-05–Present Privatdozent (Lecturer) – Department of Pediatrics, Faculty of Medicine, 

University of Cologne, Cologne, Germany 

May-06–Jun-11 Assistant Professor – Department of Paediatrics, Faculty of Medicine, 

University of Toronto, Toronto, Ontario 

Nov-06–Present Associate Scientist – Program in Cell Biology, Research Institute, 

The Hospital for Sick Children, Toronto, Ontario 

Apr-09–Present Associate Member – Institute of Medical Science, Faculty of Medicine, 


Oct-10–Present Associate Member – Laboratory Medicine and Pathobiology, Faculty of Medicine, 


July-11– Present Associate Professor – Department of Paediatrics, Faculty of Medicine, 


Hospital Appointments: 

Nov-05–Apr-06 Staff Physician – Division of Nephrology, 

Children's Hospital of the University of Cologne, Cologne, Germany 

May-06–Present Staff Physician – Division of Nephrology, 



July-07–Present Associate Staff Physician – Division of Emergency Medicine, 


Mar-09–Present Associate Staff Physician – University Health Network, Toronto General Hospital, 

Department of Medicine, Division of Nephrology, 


Apr-10–Present Director, Program for Dialysis and Apheresis – Division of Nephrology, 


PUBLICATIONS 

Peer-Reviewed Publications: 

(PA) Principal Author; (SRI) Senior Responsible Investigator; (CPA) Co-Principal Author; (C) Collab. 

1. Michalk DV, Wingenfeld P, Licht C, Ugur T, Siar LF: The mechanisms of taurine mediated 

protection against cell damage induced by hypoxia and reoxygenation. Adv. Exp. Med. Biol., 

Taurine 2, Editors: Huxtable RJ, et al.; Plenum Press, New York, NY, 1996: 403: 223-32. C 

2. Michalk DV, Wingenfeld P, Licht C: Protection against cell damage due to hypoxia and 

reoxygenation: the role of taurine and the involved mechanisms. Amino Acids, 1997: 13: 337-46. 

SRI 

3. Licht C, Schmidt B, Kribs A, Roth B, Michalk DV: Memorandum zur Neuregelung der §§ 218 

und 219. (Memorandum concerning the revision of sections 218 and 219 of the German criminal 

code.) Z. Geburtsh. Neonatol., 1997: 201: 181. PA 

4. Licht C, Kriegesmann E, Minor T, Wingenfeld P, Isselhard W, Michalk DV: Influence of taurine 

supplementation on ischemic preservation of the isolated rat kidney. Adv. Exp. Med. Biol., 

Taurine 3. Cellular and Regulatory Mechanisms, Editors: Huxtable RJ, et al.; Plenum, Press, New 

York, NY, 1998: 442: 201-6. PA 

5. Licht C, Eifinger F, Gharib M, Offner G, Michalk DV, Querfeld U: A stepwise approach to the 

treatment of early onset nephrotic syndrome. Pediatr. Nephrol., 2000: 14: 12: 1077-82. PA 

6. Licht C, Hell K, Eifinger F, Hoppe B, Querfeld U: Posttransplant lymphoproliferative disease in a 

child: clinical and molecular characterization. Pediatr. Nephrol., 2002: 17: 2: 79-84. PA 

7. Licht C, Model P, Kribs A, Herkenrath P, Michalk DV, Haupt WF, Göhring UJ, Roth B: 

Transiente neonatale Myasthenia gravis. (Transient neonatal Myasthenia gravis.) Nervenarzt, 

2002: 73: 8: 774-8. PA 

8. Ko SBH, Luo X, Hager H, Rojek A, Choi JY, Licht C, Suzuki M, Muallem S, Nielsen S, Ishibashi 

K: AE4 is a DIDS-sensitive Cl - /HCO - 3 exchanger in the basolateral membrane of the renal CCD 

and the SMG duct. Am. J. Physiol. Cell Physiol., 2002: 283: 4: C1206-18. C 

9. Anderweit S, Licht C, Kribs A, Woopen C, Bergdolt K, Roth B: Das Problem der verantworteten 

Therapieentscheidung in der Neonatologie. Kölner Arbeitsbogen zur ethischen 

Entscheidungsfindung in der Neonatologie. (The Problem of Responsible Therapeutic Decision 

Making in Neonatology. Cologne Guide for Ethical Decision Making in Neonatology.) Ethik 

Med., 2004: 16: 1: 37-47. C 


10. Aretz S, Licht C, Roth B: Endogenous Distress in Ventilated Full-Term Newborns with Acute 

Respiratory Failure. Biol. Neonate, 2004: 85: 4: 243-8. C 

11. Licht Ch, Model P, Kribs A, Herkenrath P, Michalk DV, Haupt WF, Roth B: Transiente 

neonatale Myasthenia gravis. (Transient neonatal Myasthenia gravis.) Monatsschr. Kinderheilkd, 

2004: 152: 555-60. PA 

12. Licht C, Schickendantz S, Sreeram N, Arnold G, Rossi R, Vierzig A, Mennicken U, Roth B: 

Prolonged survival in alveolar capillary dysplasia syndrome. Eur. J. Pediatr., 2004: 163: 3: 181-2. 

PA 

13. Licht C, Laghmani K, Yanagisawa M, Preisig PA, Alpern RJ: An autocrine role for endothelin-1 

in the regulation of proximal tubule NHE3. Kidney Int., 2004: 65: 4: 1320-6. PA 

14. Licht C, Stapenhorst L, Simon T, Budde U, Schneppenheim R, Hoppe B: Two novel ADAMTS13 

gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). 

Kidney Int., 2004: 66: 3: 955-8. PA 

15. Horstmeyer A, Licht C, Scherr G, Eckes B, Krieg T: Signalling and regulation of collagen I 

synthesis by ET-1 and TGF-ß1. FEBS J., 2005: 272: 24: 6297-309. C 

16. Licht C, Weyersberg A, Heinen S, Stapenhorst L, Devenge J, Beck B, Waldherr R, Kirschfink M, 

Zipfel PF, Hoppe B: Successful Plasma Therapy for Atypical Hemolytic Uremic Syndrome 

Caused by Factor H Deficiency Owing to a Novel Mutation in the Complement Cofactor Protein 

Domain 15. Am. J. Kidney Dis., 2005: 45: 2: 415-21. PA 

17. Mueller A, Beck B, Theilemann K, Stapenhorst L, Licht C, Michalk D, Franzen C, Hoppe B: 

Detection of Polyomavirus BK and JC in Children with Kidney Diseases and Renal Transplant 

Recipients. Pediatr. Infect. Dis. J., 2005: 24: 9: 778-81. C 

18. Heimann K, Grabensee A, Bald R, Licht C, Roth B: Agenesie des Ductus venosus mit direkter 

Mündung der Umbilikalvene in die Vena cava inferior: Fallvorstellung mit Verlauf und 

Literaturübersicht. (Combination of agenesis of the ductus venosus and channeling of the umbilical 

vein into the vena cava inferior: case report with long-term outcome and literature review.) 

Geburtsh. u. Frauenheilk., 2005: 65: 620-4. C 

19. Zipfel PF, Misselwitz J, Licht C, Skerka C: The Role of Defective Complement Control in 

Hemolytic Uremic Syndrome. Semin. Thromb. Hemost., 2006: 32: 2: 146-54, Review. C 

20. Józsi M, Heinen S, Hartmann A, Ostrowicz CW, Hälbich S, Richter H, Kunert A, Licht C, 

Saunders RE, Perkins SJ, Zipfel PF, Skerka C: Factor H and Atypical Hemolytic Uremic 

Syndrome: Mutations in the C-Terminus Cause Structural Changes and Defective Recognition 

Functions. J. Am. Soc. Nephrol., 2006: 17: 1: 170-7. C 

21. Licht C*, Heinen S*, Józsi M, Löschmann I, Saunders RE, Perkins SJ, Waldherr R, Skerka C, 

Kirschfink M, Hoppe B, Zipfel PF: Deletion of Lys224 in regulatory domain 4 of Factor H reveals 

a novel pathomechanism for dense deposit disease (MPGN II). Kidney Int., 2006: 70: 1: 42-50. 

PA 

22. von Schnakenburg C, Feneberg R, Plank C, Zimmering M, Arbeiter K, Bald M, Fehrenbach H, 

Griebel M, Licht C, Konrad M, Timmermann K, Kemper MJ: Percutaneous endoscopic 

gastrostomy in children on peritoneal dialysis. Perit. Dial. Int., 2006: 26: 1: 69-77. C 

23. Wolf MTF, Beck BB, Zaucke F, Kunze A, Misselwitz J, Ruley J, Ronda T, Fischer A, Eifinger F, 

Licht C, Otto E, Hoppe B, Hildebrandt F: The Uromodulin C744G mutation causes MCKD2 and 


FJHN in children and adults and may be due to a possible founder effect. Kidney Int., 2007: 71: 6: 

574-81. C 

24. Zipfel PF, Edey M, Heinen S, Józsi M, Richter H, Misselwitz J, Hoppe B, Routledge D, Strain L, 

Hughes AE, Goodship JA, Licht C, Goodship THJ, Skerka C: Deletion of Complement Factor H- 

Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome. 

PLoS Genet., 2007: 3: 3: e41: 387-92. C 

25. Dörbecker C, Licht C, Körber F, Plum G, Haefs C, Hoppe B, Seifert, H: Community-acquired 

pneumonia due to Bordatella holmesii in a patient with frequently relapsing nephrotic syndrome. 

J. Infect., 2007: 54: 4: e203-5. C 

26. Gerstung M, Roth T, Dienes H-P, Licht C, Fries JWU: Endothelin-1 Induces NF-kB via Two 

Independent Pathways in Human Renal Tubular Epithelial Cells. Am. J. Nephrol., 2007: 27: 3: 

294-300. C 

27. Smith RJH, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, 

Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, 

Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, 

Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF, Dense Deposit Disease Focus Group: 

New Approaches to the Treatment of Dense Deposit Disease. J. Am. Soc. Nephrol., 2007: 18: 9: 

2447-56, Review. C 

28. Józsi M*, Licht C*, Strobel S, Zipfel SLH, Richter H, Heinen S, Zipfel PF, Skerka C: Factor H 

autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. 

Blood, 2008: 111: 3: 1512-4. CPA 

29. Gerth C, Zawadzki RJ, Licht C, Werner JS, Héon E: A microstructural retinal analysis of 

membrano-proliferative glomerulonephritis type II. Br. J. Ophthalmol., 2008: 92: 8: 1150-1. C 

30. Licht C, Fremeaux-Bacchi V: Hereditary and acquired complement dysregulation in 

membranoproliferative glomerulonephritis. Thromb. Haemost., 2009: 101: 2: 271-8. PA 

31. Choi N, Pluthero FG, Licht C: Intracellular localization and release of platelet vascular 

endothelial growth factor. JULS, 2009: 3: 1: 40-3. SRI 

32. De S, Al-Nabhani D, Thorner P, Cattran D, Piscione TD, Licht C: Remission of resistant MPGN 

type I with mycophenolate mofetil and steroids. Pediatr. Nephrol., 2009: 24: 597-600. SRI 

33. Gross O, Borza DB, Anders HJ, Licht C, Weber M, Segerer S, Torra R, Gubler MC, Heidet L, 

Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson 

DR, Antignac C, Tryggvason K, Hudson B, Miner JH: Stem cell therapy for Alport syndrome: the 

hope beyond the hype. Nephrol. Dial. Transplant., 2009: 24: 3: 731-4. C 

34. Ariceta G, Besbas N, Johnson S, Karpman D, Landau D, Licht C, Loirat C, Pecoraro C, Taylor 

CM, Van de Kar N, VandeWalle J, Zimmerhackl LB; The European Paediatric Study Group for 

HUS: Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic 

syndrome. Pediatr. Nephrol., 2009: 24: 687-96. C 

35. Habbig S, Mihatsch MJ, Heinen S, Beck B, Emmel M, Skerka C, Kirschfink M, Hoppe B, Zipfel 

PF, Licht C: C3 deposition glomerulopathy due to a functional Factor H defect. Kidney Int., 

2009: 75: 11: 1230-4. SRI 

36. Lemaire M, Chitayat, D, Geary DF, Bichet DG, Licht C: A novel disease-causing mutation in 

AVPR2: Q96H. NDT Plus, 2009: 2: 1: 20-22. SRI 


37. Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B, Geary DF, Zipfel PF, Kahr WHA: 

Platelet-associated complement Factor H in normal individuals and patients with atypical HUS. 

Blood, 2009: 114: 20: 4538-45. PA 

38. De S, Waters AM, Segal AO, Trautmann A, Harvey EA, Licht C: Severe atypical HUS caused by 

CFH S1191L – case presentation and review of treatment options. Pediatr. Nephrol., 2010: 25: 1: 

97-104. SRI 

39. Chaturvedi S, Licht C, Langlois V: Hemolytic uremic syndrome caused by Bordetella pertussis 

infection. Pediatr. Nephrol., 2010: 25: 1361-4. C 

40. Zipfel PF, Mache C, Müller D, Licht C, Wigger M, Skerka C; for the European DEAP-HUS Study 

Group: DEAP-HUS: Deficiency of CFHR plasma proteins and autoantibody-positive form of 

hemolytic uremic syndrome. Pediatr. Nephrol., 2010: 25: 10: 2009-19. C 

41. Wine E, Shen-Tu G, Gareau MG, Goldberg HA, Licht C, Ngan BY, Sorensen ES, Greenaway J, 

Sodek J, Zohar R, Sherman PM: Osteopontin Mediates Citrobacter rodentium-Induced Colonic 

Epithelial Cell Hyperplasia and Attaching-Effacing Lesions. Am. J. Pathol., 2010: 177: 3: 1320- 

32. C 

42. El-Hout Y, Licht C, Pippi Salle JL, Ngan BY, Bagli DJ, Lorenzo AJ, Farhat WA: Hypertension in 

children with poorly functioning unilateral kidneys: predictors of resolution after nephrectomy. 

BJU Int., 2010: 106: 9: 1376-80. C 

43. Lemaire M, Connolly B, Harvey E, Licht C: Treatment of pediatric vancomycin intoxication: a 

case report and review of the literature. NDT Plus, 2010: 3: 3: 260-4. SRI 

44. Kanbur N, Pinhas L, Lorenzo A, Farhat W, Licht C, Katzman DK: Nocturnal Enuresis in 

Adolescents with Anorexia Nervosa: Prevalence, Potential Causes, and Pathophysiology. Int. J. 

Eat. Disord., 2011: 44: 4: 349-55. C 

45. Chaturvedi S, Brandao L, Geary D, Licht C: Primary antiphospholipid syndrome presenting as 

renal vein thrombosis and membranous nephropathy. Pediatr. Nephrol., 2011: 26: 6: 979-85. SRI 

46. Piscione TD, Licht C: Genetics of Proteinuria: An Overview of Gene Mutations Associated with 

Nonsyndromic Proteinuric Glomerulopathies. Adv. Chronic Kidney Dis., 2011: 18: 4: 273-89. SRI 

47. Gross O, Licht C, Anders HJ, Hoppe B, Beck B, Tönshoff B, Höcker B, Wygoda S, Ehrich JHH, 

Pape L, Konrad M, Rascher W, Doetsch J, Müller-Wiefel DE, Hoyer P, and Members of the 

Gesellschaft für Pädiatrische Nephrologie (GPN) Study Group, Knebelmann B, Pirson Y, Grunfeld 

J-P, Niaudet P, Cochat P, Heidet L, Torra R, Friede T, Lange K, Müller GA*, Weber M*: Proof of 

concept for early intervention in chronic kidney disease: ACE-inhibition delays renal failure in 

patients with Alport syndrome in a time dependent manner. Kidney Int., 2011: submitted. CA 

48. Radhakrishnan S, Brandao L, Licht C: Thromboembolism in Nephrotic Syndrome: A Single 

Center Experience with Predictors, Management and Outcomes. J. Thromb. Haemost., 2011: 

submitted. SRI 

49. van Eimeren VF, Pluthero FG, Kahr WHA, Licht C: Granule-independent platelet uptake and 

release of complement factor H. Blood, 2011: submitted. SRI 

50. Hooper DK, Williams JC, Carle AC, Chand D, Amaral SG, Patel H, Licht C, Ferris M, Bastian V, 

Barletta G-M, Mitsnefes M, Patel UD: Formal Transition and the Quality of Cardiovascular 

Disease Care for Adolescents with Kidney Disease: A Midwest Pediatric Nephrology Consortium 

Study. Clin. J. Am. Soc. Nephrol., 2011: submitted. C 


51. Heinen S, Pluthero FG, van Eimeren V, Quaggin SE, Licht C: Monitoring and Modeling 

Treatment of Atypical Hemolytic Uremic Syndrome. J. Clin. Invest., 2011: submitted. SRI 

52. Radhakrishnan S, Lunn A, Langlois V, Thorner PS, Pluthero FG, Kirschfink M, Licht C: 

Successful Treatment of Refractory MPGN Targetting Complement. N. Engl. J. Med., 2011: 

submitted. SRI 

Invited Publications (e.g. Editorials, Reviews, and Book Chapters): 


1. Licht C, Roth B: Überlegungen zu ethischen Problemen von Mehrlingsschwangerschaften. 

(Thoughts on ethical Problems of multiple Pregnancies.) Mehrlingsschwangerschaft und 

Mehrlingsgeburt (Multiple Pregnancies and Births), Editor: Schröder W; Thieme Stuttgart, 

Germany, 2001: 159-63. PA 

2. Licht C, Büscher R: Hypertension. Differentialdiagnose Pädiatrie, Editors: Michalk DV, 

Schönau E; Urban & Fischer München, Jena, Germany, 2005: 41-54. PA 

3. Licht C, Hoppe B: Complement defects in children which result in kidney diseases: diagnosis and 

therapy. Complement and Kidney Disease, Editor: Zipfel PF; in Progress in Inflammation 

Research, Series Editor: Parnham MJ; Birkhäuser, Basel, Switzerland, 2006: 165-97. PA 

4. Licht C, Schlötzer-Schrehardt U, Kirschfink M, Zipfel PF, Hoppe B: MPGN II – genetically 

determined by defective complement regulation? Pediatr. Nephrol., 2007: 22: 1: 2-9. PA 

5. Skerka C, Licht C, Zipfel PF: Inherited and acquired disorders of the complement system. 

Encyclopedia of Molecular Mechanisms of Disease, Springer Publishing House, 2007. C 

6. Licht C, Mengel M: Membranoproliferative Glomerulonephritis. Comprehensive Pediatric 

Nephrology, 1 st Edition, Editors: Geary DF, Schäfer F; Mosby Elsevier, 2008: 269-89. PA 

7. Lemaire M, Radhakrishnan S, Licht C: Fluids, Electrolytes and Acid-Base. The Hospital for Sick 

Children Handbook of Pediatrics, 11 th Edition, Editors: Dipchand A, Friedman J, Bismilla Z, 

Gupta S, Lam C; Saunders Elsevier, 2009: Chapter 16: 284-312. SRI 

8. Skerka C, Licht C, Mengel M, Uzonyi B, Strobel S, Zipfel PF, Józsi M: Autoimmune forms of 

thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a 

disease spectrum and common pathogenic principles. Mol. Immunol., 2009: 46: 2801-7. CPA 

9. Braun M, Licht C, Strife F: Membranoproliferative Glomerulonephritis. Pediatr. Nephrol., 6 th 

Edition, Editors: Avner ED, Harmon WE, Niaudet P, Yoshikawa N; Springer, 2009. C 

10. Chaturvedi S, Licht C: Glomerulopathies associated with systemic disease: Hemolytic uremic 

syndrome. Clinician’s Manual of Pediatric Nephrology, Editors: Chand DH, Valentini RP; 2010. 

SRI 

11. Neuhaus TJ, Langlois V, Licht C: Behavioural abnormalities in children with nephrotic syndrome 

– an underappreciated complication of a standard treatment? Nephrol. Dial. Transplant., 2010: 25: 

8: 2397-9. SRI 

12. Waters AM, Licht C: aHUS caused by complement dysregulation: new therapies on the horizon. 

Pediatr. Nephrol., 2011: 26: 41-57. SRI 


13. Allen U, Licht C: Pandemic H1N1 influenza A infection and (atypical) HUS – more than just 

another trigger? Pediatr. Nephrol., 2011: 26: 3-5. SRI 

14. Riedl M, Licht C: HUS oder MPGN – Gemeinsamkeiten und Unterschiede. (HUS or MPGN – 

similarities and differences.) Der Nephrologe, 2011: July 8 accepted/in press. SRI 

Abstracts: 


1. Rietschel E, Heinemann A, Licht C, Michalk DV: Hepatitis B und/oder Mukoviszidose als 

Ursache eines Hyperspleniesyndroms. (Hepatitis B and/or mucoviscidosis as cause for 

hypersplenism.) 95. Jahrestagung der Deutschen Gesellschaft für Kinderheilkunde und 

Jugendmedizin (95 th Annual Meeting of the German Society for Pediatrics and Adolescent 

Medicine), Würzburg, Germany, September 11-14, 1993. Monatsschr. Kinderheilkd., 1993: 141: 

S91. C 

2. Wingenfeld P, Licht C, Farrokh-Siar L, Sonntag A, Michalk DV: Verbesserung verschiedener 

Organkonservierungsloesungen durch den Zusatz von Taurin. (Improvement of organ preservation 

solutions by taurine.) 92. Jahrestagung der Deutschen Gesellschaft für Kinderheilkunde und 

Jugendmedizin (92 nd Annual Meeting of the German Society for Pediatrics and Adolescent 

Medicine), Lübeck, Germany, September 14–17, 1996. Monatsschr. Kinderheilkd., 1996: 144: 

214. C 

3. Wingenfeld P, Licht C, Figiel L, Farrokh-Siar L, Paas S, Uguz T, Sonntag A, Michalk DV: 

Protection against cell damage due to hypoxia and reoxygenation: a new function of metabolic 

waste products. 32. Arbeitstagung für Pädiatrische Forschung (32 nd Workshop for Pediatric 

Research), Göttingen, Germany, February 15-16, 1996. Eur. J. Pediatr., 1996: 155: 153. C 

4. Licht C, Roth B, Lechler E, v. Kleist-Retzow J-Ch, Michalk DV: Frühmanifestation eines 

heterozygoten Protein C-Mangels? (Early clinical manifestation of heterozygous protein C 

deficiency?) 22. Jahrestagung der Deutsch-Österreichischen Gesellschaft für Neonatologie und 

Pädiatrische Intensivmedizin vom (22 nd Annual Meeting of the German-Austrian Society for 

Neonatology and Pediatric Intensive Care Medicine), Dresden, Germany, September 19-21, 1996. 

Z. Geburtsh. Neonatol., 1996. PA 

5. Licht C, Roesen R, Berkels R, Klaus W, Michalk DV, Roth B: NO-Synthese von pulomonalen 

Fibroblasten bei alveolo-kapillärer Dysplasie. (NO synthesis of pulmonary fibroblasts in alveolocapillary 

dysplasia.) 27. Wissenschaftliche Tagung der Arbeitsgemeinschaft Pädiatrische 

Nephrologie (27 th Annual Meeting of the German Working Group for Pediatric Nephrology), 

Zürich, Switzerland, March 13-15, 1997. Monatsschr. Kinderheilkd., 1997: 145, Suppl. 1: 132. 

PA 

6. Licht C, Rösen R, Berkels R, Klaus W, Michalk DV, Roth B: NO-Synthese von Pulmonalen 

Fibroblasten bei Alveolo-kapillärer Dysplasie. (NO synthesis of pulmonary fibroblasts in alveolocapillary 

dysplasia.) 23. Jahrestagung der Deutsch-Österreichischen Gesellschaft für Neonatologie 

und Pädiatrische Intensivmedizin (23 rd Annual Meeting of the German-Austrian Society for 

Neonatology and Pediatric Intensive Care Medicine), Münster, Germany, October 16-18, 1997. Z. 

Geburtsh. Neonatol., 1997: 201: 221, P47. PA 

7. Licht C, Rossi R, Vierzig A, Schickendantz S, Arnold G, Mennicken U, Roth B: Chronische 


Inhalation von Stickstoffmonoxid (iNO) bei Alveolo-kapillärer Dysplasie. [Chronic inhalation of 

NO (iNO) in alveolo-capillary dysplasia.] 23. Jahrestagung der Deutsch-Österreichischen 

Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (23 rd Annual Meeting of the 

German-Austrian Society for Neonatology and Pediatric Intensive Care Medicine), Münster, 

Germany, October 16-18, 1997. Z. Geburtsh. Neonatol., 1997: 201: 227, P72. PA 

8. Licht C, Kriegesmann E, Minor T, Wingenfeld P, Isselhard W, Michalk DV: Einfluss von Taurin 

auf die ischämische Konservierung von isolierten Rattennieren. (Influence of taurine on the 

ischemic preservation of isolated rat kidneys.) 6. Jahrestagung der Deutschen Transplantations- 

Gesellschaft (6 th Annual Meeting of the German Transplant Society), Köln, Germany, November 

27-29, 1997: 122, P-45. PA 

9. Aretz S, Vierzig A, Licht C, Stützer H, Roth B: Abhängigkeit des Bedarfs an Analgetika und 

Sedativa bei beatmeten Neugeborenen vom Ausmaß des akuten Lungenversagens. (Correlation of 

the need of analgetic and sedative drugs in ventilated newborns and the degree of acute pulmonary 

failure). 23. Jahrestagung der Deutschen Gesellschaft zum Studium des Schmerzes (23 rd Annual 

Meeting of the German Society for the Study of Pain), Düsseldorf, Germany, October 14-18, 1998. 

Der Schmerz, 1998: 58: S66. C 

10. Licht C, Roth B, Lechler E, Michalk DV: Early manifestation of a heterozygous protein C 

deficiency. 42 nd Annual Meeting of the GTH (Gesellschaft für Thrombose- und 

Hämostaseforschung – Society for Thrombosis- and Hemostasis-Research), Frankfurt, Germany, 

February 25-28, 1998. Ann. Hematol., 1998: 76, Supp. 1: A35, P30. PA 

11. Licht C, Korge BP, Michel O, van Königsbruggen S, Ahrens F, Michalk DV, Rietschel E: 

Chronischer Stridor und Aphonie als Komplikation des Kindler-Syndroms. (Chronic stridor and 

aphonia as complications in Kindler Syndrome.) 20. Jahrestagung der Gesellschaft für 

Pädiatrische Pneumologie (20 th Annual Meeting of the Society for Pediatric Pneumology), 

Freiburg, Germany, April 2-4, 1998. Monatsschr. Kinderheilkd., 1998: 146: 286, P30. PA 

12. van Königsbruggen S, Ahrens F, Licht C, Kurowski C, Brockmann M, Gharib M, Benz-Bohm G, 

Michalk D, Rietschel E: Seltene Form einer Congenitalen Zystischen Adenomatoiden 

Malformation (CCAM Typ IV). [Report of a rare congenital cystic adenomatatoide malformation 

(CCAM type IV).] 20. Jahrestagung der Gesellschaft für Pädiatrische Pneumologie (20 th Annual 

Meeting of the Society for Pediatric Pneumology), Freiburg, Germany, April 2-4, 1998. 

Monatsschr. Kinderheilkd., 1998: 146: 287, P34. C 

13. Adelmann C, Kribs A, Keuth B, Licht C, Roth B: Doppelblinder, Randomisierter Vergleich von 

Sufentanil und Fentanyl in der Analgo-Sedierung Beatmeter reifer Neugeborener mit Schwerem 

Lungenversagen. (Double blinded randomized comparison of sufentanil and fentanyl as analgosedativum 

for ventilated interm babys with high degree pulmonary failure.) 24. Jahrestagung der 

Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (24 th Annual Meeting of the 

Society for Neonatology and Pediatric Intensive Care Medicine), Frankfurt, Germany, September 

10-12, 1998. Z. Geburtsh. Neonatol., 1998: 202, Suppl. 1: 9. C 

14. Heimann K, Grabensee A, Bald R, Licht C, Roth B: Fehlbildung der Umbilikalvene. (Dysplasia 

of the umbilical vein.) 24. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische 

Intensivmedizin (24 th Annual Meeting of the Society for Neonatology and Pediatric Intensive Care 

Medicine), Frankfurt, Germany, September 10-12, 1998. Z. Geburtsh. Neonatol., 1998: 202, 

Suppl. 1: 32. C 

15. Aretz S, Vierzig A, Licht C, Stützer H, Roth B: Abhängigkeit des Bedarfs an Analgetika und 

Sedativa bei beatmeten Neugeborenen vom Ausmass des akuten Lungenversagens als Hinweis für 


eine schmerzunabhängige, endogen, distressbedingte Ätiologie. (Correlation of the need of 

analgetic and sedative drugs in ventilated newborns and the degree of acute pulmonary failure as 

indicator for an aitiology depending on endogenous distress and not on pain.) 24. Jahrestagung der 



10-12, 1998. Z. Geburtsh. Neonatol., 1998: 202, Suppl. 1: 40. C 

16. Licht C, Model P, Kribs A, Herkenrath P, Michalk DV, Haupt WF, Roth B: Transiente Neonatale 

Myasthenia Gravis. (Transient myasthenia gravis of the newborn.) 24. Jahrestagung der 



10-12, 1998. Z. Geburtsh. Neonatol., 1998: 202, Suppl. 1: 40-1. PA 

17. Licht C, Kriegesmann E, Wingenfeld P, Isselhard W, Michalk DV: Taurine supplementation 

reduces the injury due to hypoxia and reperfusion in the isolated rat kidney. 11 th Congress of the 

International Pediatric Nephrology Association, London, England, September 12-16, 1998. 

Pediatr. Nephrol., 1998: 12: C94, 46.02(O) (Oral Presentation). PA 

18. Keuth B, Licht C, Offner G, Michalk DV, Querfeld U: Individualized stepwise approach to the 

treatment of congenital/infantile nephrotic syndrome. 11 th Congress of the International Pediatric 

Nephrology Association, London, England, September 12-16, 1998. Pediatr. Nephrol., 1998: 12: 

7: C160, P244. C 

19. Licht C, Schmidt B, Kribs A, Roth B, Michalk DV: Neufassung des Abtreibungsrechts. (Revision 

of the German laws concerning abortion.) Geburtsh. u. Frauenheilk., 1998: 58: M18. PA 

20. Licht C, Keuth B, Offner G, Michalk DV, Querfeld U: Stufenschema zur Behandlung des 

kongenitalen nephrotischen Syndroms. (A stepwise approach to the treatment of 

congenital/infantile nephrotic syndrome.) Monatsschr. Kinderheilkd., 1998: 146: S183. PA 

21. Licht C, Minor T, Isselhard W, Michalk DV: Einfluss von Taurin auf die ischämische 

Konservierung von isolierten Rattennieren. (Influence of taurine on the ischemic preservation of 

isolated rat kidneys.) Monatsschr. Kinderheilkd., 1998: 146: 187. PA 

22. Licht C, Gharib S, Rietschel E, Korge BP, Heidenreich A, Querfeld U, Michalk DV: 

Stimmbandsynechie und Blasenadenom als Komplikationen beim Kindler-Syndrom. (Vocal cord 

synechia and bladder adenoma as complications of Kindler Syndrome.) 94. Jahrestagung der 

Deutschen Gesellschaft für Kinderheilkunde und Jugendmedizin (94 th Annual Meeting of the 

German Society for Pediatrics and Adolescent Medicine), Dresden, Germany, October 2-5, 1998. 

Monatsschr. Kinderheilkd., 1998: 146, Suppl. 2. PA 

23. Licht C, Eifinger F, Offner G, Michalk DV, Querfeld U: Behandlung niereninsuffizienter Kinder 

im ersten Lebensjahr – Erfahrungen der Kölner Universitaetskinderklinik 1990-1998. (Treatment 

of children with end-stage renal disease during the first year of life – experiences of the Children's 

Hospital of the University of Cologne 1990-1998.) 29. Wissenschaftliche Tagung der 

Arbeitsgemeinschaft Pädiatrische Nephrologie (29 th Annual Meeting of the German Working 

Group for Pediatric Nephrology), Freiburg, Germany, March 18-20, 1999. Monattschr. 

Kinderheilkd., 1999: 147: 207, V13 (Oral Presentation). PA 

24. Licht C, Hoppe B, Hell K, Michalk DV, Querfeld U: Posttransplant lymphoproliferative disease 

(PTLD) unter immunsuppressiver Therapie mit Cyclosporin A und Mycophenolat Mofetil. 

[Posttransplant lymphproliferative disease (PTLD) occuring during therapy with cyclosporine A 

and mycophenolate mofetil.] 29. Wissenschaftliche Tagung der Arbeitsgemeinschaft Pädiatrische 



Freiburg, Germany, March 18-20, 1999. Monattschr Kinderheilkd., 1999: 147: 230, P71. PA 

25. Licht C, Eifinger F, Offner G, Michalk DV, Querfeld U: Stufenschema zur Behandlung des 

kongenitalen und infantilen nephrotischen Syndroms. (A stepwise approach to the treatment of 

congenital/infantile nephrotic syndrome.) 29. Wissenschaftliche Tagung der Arbeitsgemeinschaft 

Pädiatrische Nephrologie (29 th Annual Meeting of the German Working Group for Pediatric 

Nephrology), Freiburg, Germany, March 18-20, 1999. Monatsschr. Kinderheilkd., 1999: 147: 235, 

P90. PA 

26. Gharib S, Bald R, Kribs A, Licht C, Gharib M, Michalk DV, Roth B: Fetaler Aszites bei 

obstruktiver Uropathie. (Fetal ascites in obstructive uropathy.) 29. Wissenschaftliche Tagung der 

Arbeitsgemeinschaft Pädiatrische Nephrologie (29 th Annual Meeting of the German Working 

Group for Pediatric Nephrology), Freiburg, Germany, March 18-20, 1999. Monatsschr. 

Kinderheilkd., 1999: 147: 238, P100. C 

27. Licht C, Laghmani K, Preisig PA, Yanagisawa M, Alpern RJ: An autocrine role for endothelin-1 

(ET-1) in acid regulation of the proximal tubule. American Society of Nephrology, 33 rd Annual 

Meeting and Scientific Exposition – Renal Week 2000, October 12-15, 2000, Toronto, Ontario. J. 

Am. Soc. Nephrol., 2000: 11: 6A. PA 

28. Licht C, Zhou XJ, Laghmani K, Yanagisawa M, Alpern RJ, Preisig PA: Endothelin-1 (ET-1) and 

the Endothelin B (ETB) Receptor Contribute to Hypokalemic Nephropathy. ASN/ISN 2001 World 

Congress of Nephrology, 34 th Annual Meeting and Scientific Exposition – Renal Week 2001, San 

Francisco, California, October 10-17, 2001. J. Am. Soc. Nephrol., 2001: 12: 709A, A3699. PA 

29. Licht C, Zhou XJ, Laghmani K, Yanagisawa M, Alpern RJ, Preisig PA: Endothelin-1 (ET-1) und 

Endothelin-B (ETB)-Rezeptor in der Entstehung der hypokaliämischen Nephropathie. [The 

endothelin B (ETB) but not the endothelin A (ETA) receptor is protective against tubulointerstitial 

injury in chronic potassium deficiency.] 33. Wissenschaftliche Tagung der Arbeitsgemeinschaft 

für Pädiatrische Nephrologie (33 rd Annual Meeting of the German Working Group for Pediatric 

Nephrology), Essen, Germany, March 7-9, 2002. Nieren- und Hochdruckkrankheiten, 2002: 31: 

46, V04 (Oral Presentation). PA 

30. Licht C, Zhou XJ, Laghmani K, Yanagisawa M, Alpern RJ, Preisig PA: Contribution of 

Endothelin-1 (ET-1)/Endothelin B (ETB) receptor pathway to hypokalemic nephropathy. National 

Kidney Foundation Clinical Nephrology 2002 Meeting, Chicago, Illinois, April 17-21, 2002. Am. 

J. Kidney Dis., 2002: 39: A22 (Oral Presentation). PA 

31. Licht C, Laghmani K, Yanagisawa M, Alpern RJ, Preisig PA: Endothelin-1 (ET-1)/endothelin B 

(ETB) receptor provides the mitogenic signal for proximal tubule hypertrophy following 

uninephrectomy. American Society of Nephrology, 35 th Annual Meeting and Scientific Exposition 

– Renal Week 2002, Philadelphia, Pennsylvania, November 1-4, 2002. J. Am. Soc. Nephrol., 

2002: 13: 94A. PA 

32. Beck B, Ulrich U, Licht C, Devenge J, Kommoss F, Vester U, Hoppe B: Denys-Drash-Syndrom 

und XY-Gonadendysgenesie. American Society of Nephrology, 35 th Annual Meeting and 

Scientific Exposition – Renal Week 2002, Philadelphia, Pennsylvania, November 1-4, 2002. J. 

Am. Soc. Nephrol., 2002: 13: 341A. PA 

33. Mehler K, Licht C, Stapenhorst L, Benz-Bohm G, Hoppe B: A Case of Rickets in Puberty with 

Concomittant Iatrogenic Vitamin D Intoxication. Joint Annual Meeting of the Société de 

Néphrologie Pédiatrique and Arbeitsgemeinschaft für Pädiatrische Nephrologie, Strasbourg, 


France, May 15–17, 2003. Pediatr. Nephrol., 2003: 18: C32, P58. C 

34. Stapenhorst L, Mehler K, Licht C, Hoppe B: Abdominal Pseudotumor Due to Yersinia Infection. 

Patient After Renal Transplantation. Joint Annual Meeting of the Société de Néphrologie 

Pédiatrique and Arbeitsgemeinschaft für Pädiatrische Nephrologie, Strasbourg, France, May 15– 

17, 2003. Pediatr. Nephrol., 2003: 18: C46, P114. C 

35. Licht C, Zhou JX, Zhang W, Yanagisawa M, Alpern RJ, Preisig PA: Role of endothelin-1 (ET- 

1)/endothelin B (ETB) receptor in the development of tubulointerstitial fibrosis in chronic 

hypokalemia. WCN 2003 – World Congress of Nephrology [Jointly organized by the European 

Renal Association and European Dialysis & Transplant Association (ERA-EDTA) 40 th Congress, 

and International Society of Nephrology (ISN) 17 th Congress], Berlin, Germany, June 8-12, 2003. 

Nephrol. Dial. Transpl., 2003: 18, Suppl. 4: 580, W102. PA 

36. Anderweit S, Licht C, Kribs A, Woopen C, Bergdolt K, Roth B: Das Problem der verantworteten 

Therapieentscheidung in der Neonatologie: Kölner Arbeitsbogen zur ethischen 

Entscheidungsfindung in der Neonatologie. (The problem of responsible decision making in 

Neonatologie: the Cologne checklist for ethicial decision making in neonatology.) 29. 

Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (29 th Annual 

Meeting of the Society of Neonatology and Pediatric Intensive Care Medicine), Köln, Germany, 

July 3-5, 2003. Z. Geburtsh. Neonatol., 2003: 207, Suppl. 1: S20, V47. C 

37. Roth B, Licht C, Herber S, Hünseler C: Unzureichende Wahrnehmung und Therapie von 

Schmerz in der Neonatologie – ein ethischer Konflikt. (Insufficient realization and therapy of pain 

in neonatology – an ethicial conflict.) 29. Jahrestagung der Gesellschaft für Neonatologie und 

Pädiatrische Intensivmedizin (29 th Annual Meeting of the Society of Neonatology and Pediatric 

Intensive Care Medicine), Köln, Germany, July 3-5, 2003. Z. Geburtsh. Neonatol., 2003: 207, 

Suppl. 1: S21, V50. C 

38. Stapenhorst L, Licht C, Mehler K, Hoppe B: Akutes Nierenversagen demaskiert ein Evans 

Syndrom als TTP/von Willebrand Faktor Cleavage Protease Mangel. (Acute renal failure reveals 

Evans Syndrome as TTP/von Willebrand factor cleavage protease deficiency.) 99. Jahrestagung 

der Deutschen Gesellschaft für Kinderheilkunde und Jugendmedizin (99 th Annual Meeting of the 

German Society for Pediatrics and Adolescent Medicine), Bonn, Germany, September 11-14, 

2003. Monatsschr. Kinderheilkd., 2003: 151: 121, KHP 02.011. C 

39. Mehler K, Stapenhorst L, Licht C, Benz-Bohm G, Stippel D, Hoppe B: Grosse perirenale 

Lymphozele verursacht signifikanten Serumkreatininanstieg nach Nierentransplantation. (Large 

perirenale lymphozele causes significant increase in serum creatinine post renal transplantation.) 

99. Jahrestagung der Deutschen Gesellschaft für Kinderheilkunde und Jugendmedizin (99 th Annual 

Meeting of the German Society for Pediatrics and Adolescent Medicine), Bonn, Germany, 

September 11-14, 2003. Monatsschr. Kinderheilkd., 2003: 151: 123, KHP 02.016. C 

40. Xiao R, Licht C, Zhou XJ, Alpern RJ, Preisig PA: The Absence of the Endothelin B (ETB) 

Receptor Does Not Protect Against Bromoethylamine Hydrobromide (BEA) Nephrotoxicity. 

American Society of Nephrology, 36 th Annual Meeting and Scientific Exposition – Renal Week 

2003, San Diego, California, November 12–17, 2003. J. Am. Soc. Nephrol., 2003: 14: 629A, SU- 

PO434, Poster. C 

41. Licht C, Gross O, Odenthal M, Dienes H-P, Michalk DV, Weber M, Fries JWU: Protective Effect 

of Ramipril in Proteinuria of COL4A3 Knockout Mice with Progressive Renal Failure – Possible 

Role of Endothelin-1. American Society of Nephrology, 36 th Annual Meeting and Scientific 

Exposition – Renal Week 2003, San Diego, California, November 12–17, 2003. J. Am. Soc. 


Nephrol., 2003: 14: 639A, SU-PO481, Poster. PA 

42. Licht C, Gross O, Odenthal M, Fries J, Dienes HP, Weber M, Michalk D: Possible role of ET- 

1/ETB-receptor in the mediation of tubulointerstitial fibrosis (TIF) in chronic proteinuria. 40. 

Arbeitstagung für Pädiatrische Forschung (40 th Workshop for Pediatric Research), Göttingen, 

Germany, February 19-20, 2004. Eur. J. Pediatr., 2004: 163: R7 (Oral Presentation). PA 

43. Licht C, Heinen S, Beck B, Devenge J, Löschmann I, Józsi M, Skerka C, Zipfel P, Hoppe B: 

Neue Mutation der regulatorischen Untereinheit von Faktor H als Ursache für eine 

membranoproliferative Glomerulonephritis Typ II (MPGN II). [Novel mutation of the regulatory 

domain of Factor H as cause of membranoproliferative glomerulonephritis type II (MPGN II).] 

35. Wissenschaftliche Tagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie (35 th Annual 

Meeting of the German Working Group for Pediatric Nephrology), Mainz, Germany, March 18- 

20, 2004. Nieren- und Hochdruckkrankheiten, 2004: 33: 154, P73. PA 

44. Licht C, Heinen S, Löschmann I, Józsi M, Hälbich S, Hartmann A, Skerka C, Zipfel P, Hoppe B: 

Functional inactivation of complement factor H results in MPGN II. 13 th Congress of the 

International Pediatric Nephrology Association, Adelaide, Australia, August 29–September 2, 

2004. Pediatr. Nephrol., 2004: 19: C115, P093 (Oral Poster). PA 

45. Odenthal M, Licht C, Fleischmann J, Jung D, Dienes H-P, Fries JWU: In vitro and in vivo 

Characterization of Alpha Smooth Muscle-Actin Promoter Dependent Hepatic and Renal 

Myofibroblast-Specific Gene Expression. Congress of Nephrology 2004, Joint Scientific Meeting, 

Basel, Germany, September 18-21, 2004. Kidney Blood Press. Res., 2004: 27: 363, P09.05. PA 

46. Licht C, Gross O., Odenthal M, Dienes H-P, Michalk DV, Weber M, Fries JWU: Potential Role 

of Endothelin-1 (ET-1)/Endothelin B (ETB)-Receptor in Tubulointerstitial Fibrosis Caused by 

Proteinuria in COL4A3 Knockout Mice. Congress of Nephrology 2004, Joint Scientific Meeting, 

Basel, Germany, September 18-21, 2004. Kidney Blood Press. Res., 2004: 27: 405, P15.12. PA 

47. Odenthal M, Wallraf J, Roth T, Licht C, Dienes HP, Fries JWU: Adenovirus-Mediated Infection 

of a Promoter-GFP Construct in Mesangial Cells as Model System for Monitoring Experimental 

Glomerulosclerosis. Congress of Nephrology 2004, Joint Scientific Meeting, Basel, Germany, 

September 18-21, 2004. Kidney Blood Press. Res., 2004: 27: 406, P15.16. C 

48. Józsi M, Heinen S, Licht C, Löschmann I, Kirschfink M, Skerka C, Perkins SJ, Hoppe B, Zipfel 

PF: A single amino acid deletion in complement factor H as a novel cause for 

membranoproliferative glomerulonephritis type II (MPGN II). Joint Annual Meeting of the 

German and Dutch Societies for Immunology (JAMI), October 20-23, 2004, Maastricht, The 

Netherlands. Immunobiol., 2004: 209: 4-6: 328, E.13. C 

49. Licht C, Heinen S, Józsi M, Löschmann I, Skerka C, Kirschfink M, Zipfel PF, Hoppe B, Michalk 

DV: Das Fehlen einer einzelnen Aminosäure (K224) in der regulatorischen Domäne von Faktor H 

deckt einen neuen Pathomechanismus für MPGN II auf. [Deletion of one amino acid (K224) in the 

regulatory domain of Factor H reveals a novel pathomechanism for MPGN II.] 41. Arbeitstagung 

für Pädiatrische Forschung (41 st Workshop for Pediatric Research), Göttingen, Germany, February 

24-25, 2005. Eur. J. Pediatr., 2005: 164: 2: R9 (Oral Presentation). PA 

50. von Schnakenburg C, Feneberg R, Plank C, Zimmering M, Arbeiter K, Bald M, Fehrenbach H, 

Griebel M, Licht C, Konrad M, Timmermann K, Kemper MJ: Perkutan-endoskopische (PEG) 

und offene Gastrostomieanlagen bei 30 Kindern unter Peritonealdialyse. [Percutaneous-endoscopic 

(PEG) and open gastrostomy in 30 children with peritoneal dialysis.] 36. Wissenschaftliche 

Tagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie (36 th Annual Meeting of the 


German Working Group for Pediatric Nephrology), Hannover, Germany, April 21-23, 2005. 

Nieren- und Hochdruckkrankheiten, 2005: 34: 143, V07. C 

51. Licht C, Beck B, Devenge J, Wolf M, Kirschfink M, Zipfel PF, Hoppe B: Therapie von aHUS 

und MPGN II mittels chronischer Faktor H-Substitution durch FFP-Infusionen. (Treatment of 

aHUS and MPGN II by chronic Factor H-substitution via FFP-infusion.) 36. Wissenschaftliche 



Nieren- und Hochdruckkrankheiten, 2005: 34: 147, V17 (Oral Presentation). PA 

52. Licht C, Scheffler M, Gross O, Odenthal M, Fries J, Weber M, Hoppe B, Michalk DV: ETB- 

Rezeptorblockade reduziert die renale tubulo-interstitielle Fibrose durch chronische Proteinurie bei 

COL4A3-Knock-out-Mäusen. (ETB-receptor blockade decreases renal tubulo-interstitial fibrosis 

caused by chronic proteinuria in COL4A3 knock-out mice.) 36. Wissenschaftliche Tagung der 

Arbeitsgemeinschaft für Pädiatrische Nephrologie (36 th Annual Meeting of the German Working 

Group for Pediatric Nephrology), Hannover, Germany, April 21-23, 2005. Nieren- und 

Hochdruckkrankheiten, 2005: 34: 149, V21 (Oral Presentation). PA 

53. Wolf M, Beck B, Devenge J, Licht C, Hoppe B: Hyperurikämie, Nephropathie und hypertrophe 

Kardiomyopathie – kardiale Beteiligung bei medullary cystic kidney disease? (Hyperuricemia, 

nephropathy, and hypertrophic cardiomyopathy – cardiac involvement in medullary cystic kidney 

disease.) 36. Wissenschaftliche Tagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie 

(36 th Annual Meeting of the German Working Group for Pediatric Nephrology), Hannover, 

Germany, April 21-23, 2005. Nieren- und Hochdruckkrankheiten, 2005: 34: 152, PA01. C 

54. Beck B, Ulrich U, Licht C, Devenge J, Kommoss F, Vester U, Hoppe B: Denys-Drash-Syndrom 

und XY-Gonadendysgenesie. (Denys-Drash-Syndrome and XY gonadal dysgenesis.) 36. 

Wissenschaftliche Tagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie (36 th Annual 

Meeting of the German Working Group for Pediatric Nephrology), Hannover, Germany, April 21- 

23, 2005. Nieren- und Hochdruckkrankheiten, 2005: 34: 153, PA02. C 

55. Beck B, Müller A, Devenge J, Wolf M, Licht C, Michalk DV, Hoppe B: BK-Virusnephropathie 

mit Verlust des Transplantats – eine weitere Komplikation für einen leidgeprüften Patienten. (BK 

nephropathy with graft loss – another complication for stressed patients.) 36. Wissenschaftliche 



Nieren- und Hochdruckkrankheiten, 2005: 34: 158, PB03. C 

56. Licht C, Niederkorn C, Devenge J, Beck B, Wolf M, Körber F, Benz-Bohm G, Michalk DV, 

Hoppe B: Langzeitverlauf nach HUS – Nachuntersuchung von Patienten der 

Universitätskinderklinik Köln. (Long-term outcome post HUS – follow-up examination of patients 

of the Childrens' Hospital of the University of Cologne.) 36. Wissenschaftliche Tagung der 



Hochdruckkrankheiten, 2005: 34: 162, PC02. PA 

57. Devenge J, Beck B, Licht C, Wolf M, Bangen U, Michalk DV, Hoppe B: Kölner Erfahrungen der 

steroidfreien Immunsuppression nach Nierentransplantation. (The Cologne experience with 

steroid-free immunosuppression post kidney transplantation.) 36. Wissenschaftliche Tagung der 



Hochdruckkrankheiten, 2005: 34: 174, PF01. C 


58. Haffner E, Schaar B, Beck B, Licht C, Michalk D, Hoppe B: Sport als Integrationsmaßnahme 

chronisch nierenkranker Kinder. (Physical exercise as tool to integrate children with chronic 

kidney disease.) 36. Wissenschaftliche Tagung der Arbeitsgemeinschaft für Pädiatrische 


Hannover, Germany, April 21-23, 2005. Nieren- und Hochdruckkrankheiten, 2005: 34: 179, 

PG02. C 

59. Licht C, Dörbecker C, Beck B, Devenge J, Wolf M, Haefs C, Plum G, Seifert H, Michalk DV, 

Hoppe B: Bordatella holmesii-sepsis als Komplikation eines akuten Schubs eines häufig 

rezidivierenden, steroidsensiblen nephrotischen Syndroms. (Bordetella holmesii-sepsis as 

complication of an acute flare of a frequent-relapsing steroid-sensitive nephrotic syndrome.) 36. 

Wissenschaftliche Tagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie (36 th Annual 

Meeting of the German Working Group for Pediatric Nephrology), Hannover, Germany, April 21- 

23, 2005. Nieren- und Hochdruckkrankheiten, 2005: 34: 184, PH07. PA 

60. Beck B, Knackfuss, Bangen U, Licht C, Devenge J, Hoppe B: Akutes Nierenversagen im 

Kindesalter: eine retrospektive Analyse der Jahre 1980-2002. (Acute renal failure in childhood: a 

retrospective analysis of the years 1980-2002.) 36. Wissenschaftliche Tagung der 



Hochdruckkrankheiten, 2005: 34: 188, PP08. C 

61. Licht Ch, Gross O, Odenthal M, Dienes H-P, Michalk DV, Weber M, Fries JWU: ET-1/ETB 

receptor in COL4a3 knock-out mice. 20 th European Congress of Pathology, Paris, France, 

September 3-8, 2005. Virchows Archiv, 2005: 447: 2: 134, O-17 (Oral Presentation). PA 

62. Licht C, Gross O, Scheffler M, Odenthal M, Fries JWU: ETB-Receptor Blockade Reduces 

Tubulointerstitial Fibrosis Caused by Chronic Proteinuria in COL4A3 Knockout Mice. American 

Society of Nephrology, 38 th Annual Meeting and Scientific Exposition – Renal Week 2005, 

Philadelphia, Pennsylvania, November 8-13, 2005. J. Am. Soc. Nephrol., 2005: 16: 220A, TH- 

PO471, Poster. PA 

63. Wolf MTF, Beck BB, Licht C, Devenge J, Hoppe B: PH 1: Beschreibung neuer AGXT- 

Mutationen und einer intrafamiliären Genotyp/Phänotyp-Variabilität. (Description of novel AGXT 

mutations and intrafamilial genotype/phenotype variability.) 37. Wissenschaftliche Jahrestagung 

der Arbeitsgemeinschaft für Pädiatrische Nephrologie (37 th Annual Meeting of the German 

Working Group for Pediatric Nephrology), Marburg, Germany, March 16-18, 2006. Nieren- und 

Hochdruckkrankheiten, 2006: 35: 57, P19. C 

64. Körber F, Devenge J, Beck B, Eifinger F, Benz-Bohm G, Hoppe B, Licht C: Verkalkungen der 

Koronargefäße bei Kindern mit dialysepflichtiger Niereninsuffizienz. (Calcification of coronary 

arteries in children with enstage renal disease on dialysis.) 37. Wissenschaftliche Jahrestagung der 


Group for Pediatric Nephrology), Marburg, Germany, March 16-18, 2006. Nieren- und 

Hochdruckkrankheiten, 2006: 35: 68, P55. SRI 

65. Licht C, Devenge J, Skerka C, Hoppe B, Kirschfink M, Zipfel PF: MPGN I und II werden durch 

verschiedene genetische Faktoren verursacht (Kölner APN-Register). [MPGN I and II are 

mediated by different genetic factors (The Cologne APN Registry).] 37. Wissenschaftliche 

Jahrestagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie (37 th Annual Meeting of the 

German Working Group for Pediatric Nephrology), Marburg, Germany, March 16-18, 2006. 

Nieren- und Hochdruckkrankheiten, 2006: 35: 73, P71. PA 


66. Devenge J, Licht C, Beck B, Simon Th, Ernestus K, Hoppe B: M. Castleman mit nephrotischem 

Syndrom: eine Kasuistik. (Morbus Castleman with nephrotic syndrome: a case report.) 37. 

Wissenschaftliche Jahrestagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie (37 th 

Annual Meeting of the German Working Group for Pediatric Nephrology), Marburg, Germany, 

March 16-18, 2006. Nieren- und Hochdruckkrankheiten, 2006: 35: 73, P72. C 

67. Scheiring J, Prüfer F, Sautter S, Neuhaus T, Sulyok E, Reusz G, Janda J, Seeman T, Urbanek R, 

Bald M, Licht C, Hoppe B, Misselwitz J, John U, Knüppel T, Tönshoff B, Griebel M, Fehrenbach 

H: Pediatric atypical/recurrent haemolytic uremic syndrome. 37. Wissenschaftliche Jahrestagung 


Working Group for Pediatric Nephrology), Marburg, Germany, March 16-18, 2006. Nieren- und 


68. Peters M, Anderweit S, Heinritz C, Hick C, Licht C, Bergdolt K, Roth B: Welche Kriterien und 

Wertvorstellungen spielen bei ethisch schwierigen Behandlungsentscheidungen in der 

Neonatologie eine Rolle? – Ergebnisse einer empirischen Studie. (What criteria and values are 

relevant for ethically difficult therapy decisions in Neonatology? – Results of an empirical study.) 

32. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (32 nd Annual 

Meeting of the Swiss, Austrian & German Society of Neonatology and Pediatric Intensive Care 

Medicine), Wien, Austria, May 18-20, 2006. Z. Geburtsh. Neonatol., 2006: 210, Suppl. 1: S4, V09 

(Oral Presentation). C 

69. Habbig S, Licht C, Stapenhorst L, Beck B, Wolf M, Devenge J, Hoppe B: Nephrocalcinosis in the 

renal allograft: prevalence and risk factors? European Society for Pediatric Nephrology, 40 th 

Annual Meeting, Palermo, Italy, October 7-10, 2006. Pediatr. Nephrol., 2006: 21: 1579, COD PP 

229. C 

70. Stapenhorst L, Gross J, Bangen U, Beck BB, Licht C, Devenge J, Michalk D, Hoppe B: A case of 

severe anemia due to anti-erythropoeitin antibodies in chronic renal failure. European Society for 

Pediatric Nephrology, 40 th Annual Meeting, Palermo, Italy, October 7-10, 2006. Pediatr. 

Nephrol., 2006: 21: 1606, COD PP 340. C 

71. Licht C, Kirschfink M, Hoppe B, Zipfel PF: Pathogenesis of MPGN I and II – Insights Derived 

from the German APN-Registry. American Society of Nephrology, 39 th Annual Meeting and 

Scientific Exposition – Renal Week 2006, San Diego, California, November 14-19, 2006. J. Am. 

Soc. Nephrol., 2006: 17: 256A, TH-PO701, Poster. PA 

72. Gross O, Licht C, Weber M: European Initiative towards Delaying Renal Failure in Alport 

Syndrome. American Society of Nephrology, 39 th Annual Meeting and Scientific Exposition – 

Renal Week 2006, San Diego, California, November 14-19, 2006. J. Am. Soc. Nephrol., 2006: 17: 

389A, F-PO243, Poster. C 

73. Habbig S, Licht C, Stapenhorst L, Beck BB, Wolf MT, Devenge J, Hoppe B: Prevalence and Risk 

Factors of Nephrocalcinosis in Pediatric Renal Transplant Recipients. American Society of 

Nephrology, 39 th Annual Meeting and Scientific Exposition – Renal Week 2006, San Diego, 

California, November 14-19, 2006. J. Am. Soc. Nephrol., 2006: 17: 545A, F-PO995, Poster. C 

74. Habbig S, Kirschfink M, Zipfel PF, Hoppe B, Licht C: Long-Term Treatment of MPGN II Due to 

Functional Factor H Defect Via FFP Infusion. American Society of Nephrology, 39 th Annual 

Meeting and Scientific Exposition – Renal Week 2006, San Diego, California, November 14-19, 

2006. J. Am. Soc. Nephrol., 2006: 17: 575A, F-PO1133, Poster. SRI 

75. Licht C, Krishnan R, Dietlein T, Gerth C, Beck B, Habbig S, Heon E, Zipfel PF, Hoppe B: 


Phenotypische Bedeutung des Faktor H-Polymorphismus Y402H bei Kindern mit Komplementbasierter 

MPGN II/DDD und aHUS. (Phenotypical relevance of the Factor H polymorphism 

Y402H in children with complement based MPGN II/DDD and aHUS.) 38. Wissenschaftliche 


German Working Group for Pediatric Nephrology), Stuttgart, Germany, March 22-24, 2007. 

Nieren- und Hochdruckkrankheiten, 2007: 36: 42, V2 (Oral Presentation). PA 

76. Habbig S, Beck B, Emmel M, Kirschfink M, Zipfel PF, Hoppe B, Licht C: Langzeittherapie von 

Kindern mit Komplement-basierter MPGN II/DDD mittels FFP-Infusion. (Long-term therapy of 

children with complement based MPGN II/DDD via FFP infusion.) 38. Wissenschaftliche 


German Working Group for Pediatric Nephrology), Stuttgart, Germany, March 22-24, 2007. 

Nieren- und Hochdruckkrankheiten, 2007: 36: 42, V3. SRI 

77. Trautmann A, Waters A, Harvey E, Zipfel PF, Licht C: Therapie mit Plasmaaustausch, 

Immunglobulinen und Steroiden ist erfolgreich bei sekundär therapierefraktärem aHUS von 

bislang unklarer Ätiologie. (Successful treatment of therapy resistant aHUS of unknown origin 

with plasma exchange, i.v. immunoglobulins, and steroids.) 38. Wissenschaftliche Jahrestagung 


Working Group for Pediatric Nephrology), Stuttgart, Germany, March 22-24, 2007. Nieren- und 

Hochdruckkrankheiten, 2007: 36: 67, P56. SRI 

78. Habbig S, Stapenhorst L, Beck B, Feldkötter M, Bangen U, Verkölen C, Licht C, Hoppe B: 

Nephrokalzinose nach Nierentransplantation – ein häufiger Befund? (Post renal transplant 

nephrocalcinosis – a frequent finding?) 38. Wissenschaftliche Jahrestagung der 


Group for Pediatric Nephrology), Stuttgart, Germany, March 22-24, 2007. Nieren- und 


79. Waters A, Al Maghrabi M, Geary D, Zipfel P, Licht C: Deficiency of FHR-1/FHR-3 Causes 

Atypical Hemolytic Uremic Syndrome. 14 th Congress of the International Pediatric Nephrology 

Association, IPNA Budapest 2007, Budapest, Hungary, August 31–September 4, 2007. Pediatr. 

Nephrol., 2007: 22: 9: 1480, 181 (Oral Poster). SRI 

80. Krishnan R, Dietlein T, Gerth C, Hoppe B, Heon E, Zipfel P, Licht C: Phenotypical Relevance of 

the Y402H Mutation of Factor H in Children with Complement Based MPGN II/DDD and aHUS. 

14 th Congress of the International Pediatric Nephrology Association, IPNA Budapest 2007, 

Budapest, Hungary, August 31–September 4, 2007. Pediatr. Nephrol., 2007: 22: 9: 1482, 190 

(Oral Poster). SRI 

81. Teskey L, Waters A, Licht C, Hebert D: An Unsolved Case of Thrombotic Microangiopathy. 14 th 

Congress of the International Pediatric Nephrology Association, IPNA Budapest 2007, Budapest, 

Hungary, August 31–September 4, 2007. Pediatr. Nephrol., 2007: 22: 9: 1544: 536. C 

82. Krishnan R, Geary D, Feigenbaum A, Heon E, Licht C: Cobalamin Deficiency as Thrombotic 

Microangiopathy and Bovine Maculopathy – Pathogenetic Role for Complement Factor H? 14 th 

Congress of the International Pediatric Nephrology Association, IPNA Budapest 2007, Budapest, 

Hungary, August 31–September 4, 2007. Pediatr. Nephrol., 2007: 22: 9: 1545: 542. SRI 

83. Waters A, Trautmann A, Zipfel P, Harvey E, Licht C: Atypical Hemolytic Uremic Syndrome: an 

Unsolved Case of Complement Dysregulation. 14 th Congress of the International Pediatric 

Nephrology Association, IPNA Budapest 2007, Budapest, Hungary, August 31–September 4, 

2007. Pediatr. Nephrol., 2007: 22: 9: 1595: 740. SRI 


84. Józsi M, Strobel S, Zipfel SLH, Richter H, Heinen S, Uzonyi B, Edey M, Routledge D, Strain L, 

Hughes AE, Goodship JA, Goodship THJ, Licht C, Zipfel PF, Skerka C: Factor H autoantibodies 

in atypical hemolytic uremic syndrome correlated with CFHRI/CFHR3 deficiency and affect 

recognition funcitons. 11 th European Meeting on Complement in Human Diseases, Cardiff, Wales, 

UK, September 8-11, 2007, Mol. Immunol., 2007: 44: 16: 3924. C 

85. Licht C, Pluthero F, Ling Li, Zipfel PF, Kahr W: Human Megakaryocytes and Platelets Express 

Endogenous Factor H – Mediators of HUS Pathogenesis. American Society of Nephrology, 40 th 

Annual Meeting and Scientific Exposition – Renal Week 2007, San Francisco, California, October 

31–November 5, 2007. J. Am. Soc. Nephrol., 2007: 18: 318A, F-PO977, Poster. PA 

86. Waters AM, Skerka C, Geary DF, Thorner PS, Zipfel PF, Licht C: A Novel Subgroup of Atypical 

HUS Characterized by Onset in Late Childhood and Factor H Autoantibodies Associated with 

CFHR-1/CFHR-3 Deficiency. American Society of Nephrology, 40 th Annual Meeting and 

Scientific Exposition – Renal Week 2007, San Francisco, California, October 31–November 5, 

2007. J. Am. Soc. Nephrol., 2007: 18: 318A, F-PO979, Poster. SRI 

87. Zipfel PF, Józsi M, Strobel S, Zipfel SLH, Richter H, Heinen S, Goodship THJ, Licht C, Skerka 

C: Factor H Autoantibodies in Atypial Hemolytic Uremic Syndrome Correlate with 

CFHR1/CFHR3 Deficiency and Affect Recognition Functions. American Society of Nephrology, 

40 th Annual Meeting and Scientific Exposition – Renal Week 2007, San Francisco, California, 

October 31–November 5, 2007. J. Am. Soc. Nephrol., 2007: 18: 318A, F-PO980, Poster. C 

88. Martin K, Keating L, Frieling M, Farhat W, Licht C: Long-Term Preservation of Renal Function 

with ACE Inhibitors in Pediatric Chronic Kidney Disease – a Single Center Experience. American 

Society of Nephrology, 40 th Annual Meeting and Scientific Exposition – Renal Week 2007, San 

Francisco, California, October 31–November 5, 2007. J. Am. Soc. Nephrol., 2007: 18: 934A, 

PUB476. SRI 

89. Krishnan RG, Heon E, Dietlein T, Tse Y, Shafiq A, Hoppe B, Skerka C, Zipfel PF, Licht C: 

Prevalence of Y402H Polymorphism in Children with Renal Diseases Associated with Defective 

Factor H Function. American Society of Nephrology, 40 th Annual Meeting and Scientific 

Exposition – Renal Week 2007, San Francisco, California, October 31–November 5, 2007. J. Am. 

Soc. Nephrol., 2007: 18: 966A, PUB622. SRI 

90. Licht C, Pluthero FG, Li L, Zipfel PF, Kahr WHA: HUS Pathogenesis: Human Megakaryocytes 

and Platelets Express Endogenous Factor H. 2007 Scientific Retreat, Research Institute, The 

Hospital for Sick Children, Toronto, Ontario, November 27, 2007. PA 

91. Skerka C, Józsi M, Licht C, Strobel S, Zipfel SLH, Richter H, Heinen S, Zipfel PF: Factor H 

autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. 

39. Wissenschaftliche Jahrestagung der Arbeitsgemeinschaft für Pädiatrische Nephrologie (39 th 

Annual Meeting of the German Working Group of Pediatric Nephrology), Jena, Germany, March 

13-15, 2008. Nieren- und Hochdruckkrankheiten, 2008: 37: 66, V16. C 

92. Gross O, Reinhard J, Brinkmann S, Lehmann C, Stietz S, Bach C, Müller GA, Weber M, Licht C: 

Zwischenergebnisse des Europäischen Alport-Registers und deren Implikationen für eine 

Therapie-Studie. (Update on the European Alport Registry – implications for a treatment study.) 



13-15, 2008. Nieren- und Hochdruckkrankheiten, 2008: 37: 77, P28. SRI 

93. Józsi M, Strobel S, Richter H, Hoyer PF, Mache CJ, Fehrenbach H, Licht C, Skerka C, Zipfel PF: 


Functional characterization of factor H autoantibodies in a typical hemolytic uremic syndrome. 



13-15, 2008. Nieren- und Hochdruckkrankheiten, 2008: 37: 88, P60. C 

94. Licht C, Pluthero FG, Li L, Zipfel PF, Kahr WHA: Faktor H in Megakaryozyten und 

Thrombozyten – mögliche Bedeutung für die Pathogenese des HUS. (Factor H in megakaryocytes 

and platelets – potential impact on the pathogenesis of HUS.) 39. Wissenschaftliche Jahrestagung 


Working Group of Pediatric Nephrology), Jena, Germany, March 13-15, 2008. Nieren- und 

Hochdruckkrankheiten, 2008: 37: 92, P73. PA 

95. Licht C, De S, Al-Nabhani D, Arora S, Thorner P, Hebert D, Zipfel PF, Kirschfink M: MPGN 

II/DDD-Rezidiv 7 Tage nach Nierentransplantation. (Recurrence of MPGN II/DDD 7 days post 

kidney transplantation.) 39. Wissenschaftliche Jahrestagung der Arbeitsgemeinschaft für 

Pädiatrische Nephrologie (39 th Annual Meeting of the German Working Group of Pediatric 

Nephrology), Jena, Germany, March 13-15, 2008. Nieren- und Hochdruckkrankheiten, 2008: 37: 

92, P74. PA 

96. Gross O, Reinhardt J, Brinckmann S, Lehmann C, Stietz S, Bach C, Müller GA, Licht C, Weber 

M: Zwischenergebnisse des Europäischen Alport-Registers und deren Implikationen für eine 

Therapie-Studie. (First results of the European Alport Registry – implications for a treatment trial.) 

Kongress für Nephrologie 2008 (Congress of Nephrology 2008), Tübingen, Germany, September 

27-30, 2008: P 030. C 

97. Licht C, Pluthero FG, Li L, Habbig S, Hoppe B, Zipfel PF, Kahr WH: HUS Pathogenesis: 

Platelets Contain and Take up Complement Factor H, Which is Located throughout the Cell and 

near the Surface. Renal Week 2008, Philadelphia, Pennsylvania, November 4-9, 2008. J. Am. 

Soc. Nephrol., 2008: 19: 183A, TH-PO337, Poster. PA 

98. Gross O, Reinhardt J, Brinckmann S, Lehmann C, Stietz S, Bach C, Torra R, Heidet L, Knebelman 

B, Chauveau D, Mueller GA, Licht C, Weber M: Interim Report of the European Alport Registry 

and Its Implications for a Prospective Trial. Renal Week 2008, Philadelphia, Pennsylvania, 

November 4-9, 2008. J. Am. Soc. Nephrol., 2008: 19: 375A, F-PO1180, Poster. C 

99. Licht C, Uzony B, Skerka C, Kirschfink M, Hoppe B, Zipfel PF: Characterization of the 

Complement System of MPGN Patients – The MPGN Registry of the "Gesellschaft Für 

Päediatrische Nephrologie (GPN)". Renal Week 2008, Philadelphia, Pennsylvania, November 4-9, 

2008. J. Am. Soc. Nephrol., 2008: 19: 561A, F-PO1996, Poster. PA 

100. Skerka C, Richter H, Strobel S, Jozsi M, Licht C, Heinen S, Zipfel P: A New Subgroup of 

Hemolytic Uremic Syndrome Is Characterized by Factor H Autoantibodies Which Develop on a 

Background of CFHR1 and CFHR3 Deficiency. Renal Week 2008, Philadelphia, Pennsylvania, 

November 4-9, 2008. J. Am. Soc. Nephrol., 2008: 19: 656A, SA-PO2432, Poster. C 

101. Habbig S, Beck B, Kirschfink M, Zipfel PF, Hoppe B, Licht C: Successful Long-Term Treatment 

of a Atypical HUS Via Periodical Plasma Infusion: Clinical and In-Vtro Observations. Renal 

Week 2008, Philadelphia, Pennsylvania, November 4-9, 2008. J. Am. Soc. Nephrol., 2008: 19: 

856A, PUB199. SRI 

102. Kahr WHA, Pluthero FG, Licht C: Complement Factor H in Human Platelets: Implications for 

Atypical HUS. American Society of Hematology (ASH) 50 th Annual Meeting and Exposition, San 

Francisco, California, December 6-9, 2008. Blood, 2008: 112: 11: 645, Abstract 1833, Poster 


Board I-938. SRI 

103. Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B, Geary DF, Zipfel PF, Kahr WHA: 

Platelet-associated complement Factor H in normal individuals and patients with atypical HUS. 

Gordon Research Conferences, Cell Biology of Megakaryocytes & Platelets in Galveston, Texas, 

March 15-20, 2009. PA 

104. Licht C, Pluthero FG, Zipfel PF, Kahr WHA: Complement Factor H in human platelets: clues for 

atypical HUS pathogenesis independent of endothelial cell damage. Pediatric Nephrology Spring 

Meeting 2009, Amsterdam, The Netherlands, March 28-31, 2009 (O-007, Oral Presentation). PA 

105. Licht C, Pluthero FG, Zipfel PF, Kahr WHA: Platelet-associated complement Factor H in normal 

individuals and patients with atypical HUS. XXII Congress, International Society on Thrombosis 

and Haemostasis. 55 th Annual Meeting of the Scientific and Standardization Committee of the 

ISTH, Boston, Massachusetts, July 11-16, 2009. J. Thromb. Haemost., 2009: 7: 2 (#OC-TU-028, 

Oral Presentation). PA 

106. Schnabl KL, Chan MK, Kirschfink M, Licht C, Adeli K: Evaluation of the analytical performance 

of a CH50 ELISA for pediatric specimens. 2009 AACC/CSCC Annual Meeting Chicago, Illinois, 

July 19-23, 2009. C 

107. Licht C, Gross O, Scheffler M, Mertens P, Odenthal M, Fries J: ET-Receptor Blockade Delays 

Progression of Tubulointerstitial Fibrosis in a Mouse Model of Alport Syndrome. ET-11: APS 

International Conference of Endothelin, Montreal, Quebec, September 9-12, 2009 (p. 30: 12.5 Oral 

Presentation). PA 

108. Al-Matrafi J, Licht C, Tinckam K, Herzenberg AM, Zipfel PF, Hebert D, Harvey E: Successful 

treatment of acute antibody-mediated rejection complicated by CFHR1 deficiency with 

complement blockage. 4 th International Workshop on Thrombotic Microangiopathies, Weimar, 

Germany, October 1-3, 2009 (Abstract #25, Oral Presentation). SRI 

109. Licht C, Pluthero FG, Zipfel P, Kahr WHA: Platelet-associated complement factor H in normal 

individuals and patients with atypical HUS. 4 th International Workshop on Thrombotic 

Microangiopathies, Weimar, Germany, October 1-3, 2009 (Abstract #6). PA 

110. Chaturvedi S, Nagel M, Hebert D, Licht C: Atypical HUS caused by both ADAMTS13 and MCP 

mutations – evidence for a single disease entity? 4 th International Workshop on Thrombotic 

Microangiopathies, Weimar, Germany, October 1-3, 2009 (Abstract #7), Poster. SRI 

111. Pluthero FG, Faggioni M, Kahr WHA, Licht C: Platelet Activation and Complement Factor H: 

Implications for Atypical HUS. Renal Week 2009, San Diego, California, October 27–November 

1, 2009. J. Am. Soc. Nephrol., 20: 2009: 636A, SA-PO2299, Poster. SRI 

112. Chaturvedi S, Nagel M, Hebert D, Licht C: Atypical HUS Caused by Both ADAMTS13 and 

MCP Mutations: Evidence for a Single Disease Entity. Renal Week 2009, San Diego, California, 

October 27–November 1, 2009. J. Am. Soc. Nephrol., 20: 2009: 636A, SA-PO2301, Poster. SRI 

113. Radhakrishnan S, Licht C, Brandao L, Frieling M: Thromboembolism and Nephrotic Syndrome. 

Renal Week 2009, San Diego, California, October 27–November 1, 2009. J. Am. Soc. Nephrol., 

20: 2009: 636A, SA-PO2303, Poster. C 

114. Gross O, Licht C, Weber M, Mueller G-A: Earlier Diagnosis Allowing Earlier Therapy Delays 

Renal Failure in Alport Syndrome: Intrafamilial Comparison of Siblings in Eight Alport Families. 

Renal Week 2009, San Diego, California, October 27–November 1, 2009. J. Am. Soc. Nephrol., 

20: 2009: 747A, SA-PO2783, Poster. C 


115. Gross O, Licht C, Müller G-A, Weber M, Mitglieder de GPN Studiengruppe: Erste 

Endergebnisse des Europäischen Alport-Registers und deren Implikationen für eine Therapie- 

Studie: eine frühe Diagnose und Therapie verzögert das Nierenversagen. (First final results of the 

European Alport registry and their impact on a treatment trial: early diagnosis and therapy delays 

end stage kidney disease.) 41. Wissenschaftliche Jahrestagung der Gesellschaft Für Pädiatrische 

Nephrologie (41 st Scientific Annual Meeting of the Association for Paediatric Nephrology), 

Universität Hamburg, Hamburg, Germany, March 25-27, 2010. Der Nephrologe, 2010: 5: Suppl. 

1: 58, Abstract 34, Poster. C 

116. van Eimeren V, Pluthero F, Kahr W, Licht C: Besonderheiten der Aufnahme und Abgabe von 

Faktor H durch Thrombozyten: Mögliche Bedeutung für die Pathogenese des aHUS. (Uptake and 

release of Factor H by platelets: possible role for aHUS pathogenesis.) 41. Wissenschaftliche 

Jahrestagung der Gesellschaft Für Pädiatrische Nephrologie (41 st Scientific Annual Meeting of the 

Association for Paediatric Nephrology), Universität Hamburg, Hamburg, Germany, March 25-27, 

2010. Der Nephrologe, 2010: 5: Suppl. 1: 73, Abstract 72, Poster. SRI 

117. Radhakrishnan S, Brandao L, Licht C: Thromboembolische Komplikationen bei Kindern mit 

nephrotischem Syndrom: ein unterschätztes Problem? (Thromboembolism in nephrotic syndrome 

in children: worse than what we thought?) 41. Wissenschaftliche Jahrestagung der Gesellschaft 

Für Pädiatrische Nephrologie (41 st Scientific Annual Meeting of the Association for Paediatric 

Nephrology), Universität Hamburg, Hamburg, Germany, March 25-27, 2010. Der Nephrologe, 

2010: 5: Suppl. 1: 73, Abstract 73, Poster. SRI 

118. Zipfel PF, Mache C, Müller D, Licht C, Wigger M, Skerka C, on behalf of the European DEAP- 

HUS study group: DEAP-HUS: Defizienz von CFHR Protein und Autoantikörper-positive Form 

des Hämolytisch Urämischen Syndromes. (DEAP HUS: deficiency-of-CFHR-proteins-andautoantibody-positive 

form of the hemolytic uremic syndrome.) 41. Wissenschaftliche 

Jahrestagung der Gesellschaft Für Pädiatrische Nephrologie (41 st Scientific Annual Meeting of the 

Association for Paediatric Nephrology), Universität Hamburg, Hamburg, Germany, March 25-27, 

2010. Der Nephrologe, 2010: 5: Suppl. 1: 94, Abstract 133, Poster. C 

119. van Eimeren V, Pluthero F, Licht C, Kahr W: Insights into the uptake and release of complement 

factor H by platelets. American Society of Pediatric Hematology/Oncology (ASPHO) 23 rd Annual 

Meeting, April 7-10, 2010, Montreal, Quebec. Pediatr. Blood Cancer, 2010: 54: 6: 807: Poster 

150. C 

120. Wei C-C, Licht C, Wang W, Smoyer WE: Epidemiology and Costs of Pediatric MPGN. 

PAS/ASPN 2010 Annual Meeting, Vancouver, British Columbia, May 1-4, 2010, Poster 2854.400. 

C 

121. Licht C, Thorner P, Kirschfink M, Skerka C, Zipfel PF: A Novel Disease Mechanism for MPGN 

II/DDD: Increased CFHR1 Expression Results in Competitive Loss of CFH Cofactor Activity. 2 nd 

International Conference: HUS, MPGN & PNH, Innsbruck, Austria, June 13-15, 2010, Poster. PA 

122. van Eimeren V, Pluthero F, Kahr W, Licht C: Insites into the Uptake and Release of Complement 

Factor H by Platelets. 15 th Congress of the International Pediatric Nephrology Association (IPNA 

2010 Congress), New York, New York, August 29–September 2, 2010. Pediatr. Nephrol., 2010: 

25: 9: 1796, Abstract #8 (O-23), Oral Presentation. SRI 

123. Lunn A, Langlois V, Licht C: Membranoproliferative Glomerulonephritis (MPGN) Type 1 – A 

Case for Complement Therapy? 15 th Congress of the International Pediatric Nephrology 

Association (IPNA 2010 Congress), New York, New York, August 29–September 2, 2010. 

Pediatr. Nephrol., 2010: 25: 9: 1876, Abstract #410, Poster. SRI 


124. van Eimeren VF, Pluthero FG, Kahr WHA, Licht C: Insights into the uptake and release of 

Complement Factor H by platelets. The Hospital for Sick Children 2010 Research Institute 

Annual Scientific Retreat, Toronto, Ontario, November 1, 2010, Poster. SRI 

125. Pinsk MN, Bernard C, Feber J, Gibson IW, Goldberg AM, Licht C, Merouani A, Wade AW, 

Blydt-Hansen TD: Canadian Pediatric IgAN/HSP: Baseline Patient Characteristics from the 

REDDCAPP Registry. Renal Week 2010, Denver, Colorado, November 16-21, 2010. J. Am. Soc. 

Nephrol., 2010: 21: 137A, TH-PO109, Poster. CA 

126. Muus P, Legendre CM, Douglas K, Hourmant M, Delmas Y, Herthelius BM, Trivelli A, Loirat C, 

Goodship TH, Licht C: Safety & Efficacy of Eculizumab in aHUS Patients on Chronic Plasma 

Therapy: Interim Analysis of a Phase II Trial. Renal Week 2010, Denver, Colorado, November 

16-21, 2010. J. Am. Soc. Nephrol., 2010: 21: 402A, F-PO1274, Poster. SRI 

127. van Eimeren VF, Pluthero FG, Kahr WH, Licht C: Platelet Uptake and Release of Complement 

Factor H. Renal Week 2010, Denver, Colorado, November 16-21, 2010. J. Am. Soc. Nephrol., 

2010: 21: 405A, F-PO1285, Poster. SRI 

128. Licht C, Thorner PS, Skerka C, Zipfel PF: A New Disease Mechanism for MPGN II/DDD: 

Increased CFHR1 Expression Results in Competitive Loss of CFH Cofactor Activity. Renal Week 

2010, Denver, Colorado, November 16-21, 2010. J. Am. Soc. Nephrol., 2010: 21: 405A, F- 

PO1286, Poster. PA 

129. Pinsk MN, Bernard C, Feber J, Gibson IW, Goldberg AM, Licht C, Merouani A, Wade AW, 

Blydt-Hansen TD: The Oxford Scoring System for IgAN Has Excellent Interobserver Consistency 

in a Population of Canadian Children. Renal Week 2010, Denver, Colorado, November 16-21, 

2010. J. Am. Soc. Nephrol., 2010: 21: 421A, F-PO1357, Poster. CA 

130. Goodship TH, Muus P, Legendre CM, Douglas K, Hourmont M, Delmas Y, Herthelius B-M, 

Trivelli A, Loirat C, Bedrosian C, Licht C: Eculizumab is an Effective Treatment for Patients 

With Atypical Hemolytic Syndrome (aHUS) on Plasma Therapy (PT). 51 st Annual Scientific 

Meeting of the British Society for Hematology (BSH), Brighton, UK, April 4-6, 2011. Br. J. 

Haematol., 2011: 153, Suppl 1: 24, Abstract 49, Oral Presentation. SRI 

131. Licht C, Lunn A, Langlois V: Membranoproliferative Glomerulonephritis Typ 1 – ein Fall für 

Komplement? (Membranoproliferative glomerulonephritis type I – a case for complement?) 42. 

Jahrestagung der Gesellschaft für Pädiatrische Nephrologie (GPN). (42 nd Annual Meeting of the 

German Working Group of Pediatric Nephrology), Bamberg, Germany, April 6-10, 2011. 

Klinische Pädiatrie, 2011: Supp1: S47, P041. PA 

132. Di Mola M, Tomlin K, Connolly B, Licht C: First successful use of the vortex port for plasma 

exchange in a small child with hyperlipidemia. 32 nd Annual Meeting of the American Society for 

Apheresis (ASFA 2011 Annual Meeting), Scottsdale, Arizona, June 1-4, 2011. J. Clin. Apheresis, 

2011: 26: 89, Abstract 55. SRI 

133. Loirat C, Muus P, Legendre C, Douglas K, Hourmant M, Delmas Y, Herthelius M, Trivelli A, 

Goodship AT, Bedrosian CL, Licht C: A Phase II Study of Eculizumab in Patients With Atypical 

Hemolytic Uremic Syndrome (aHUS) Receiving Chronic Plasma Exchange/Infusion: Interim 

Analysis. 16 th Congress of the European Hematology Association (EHA), London, UK, June 9-12, 

2011. Haematologica, 2011: 96, Suppl 2: 408, Abstract 980, Poster Presentation. SRI 

134. Loirat C, Muus P, Legendre C, Douglas K, Hourmant M, Delmas Y, Herthelius M, Trivelli A, 

Goodship T, Bedrosian CL, Licht C: Efficacy and Safety of Eculizumab in Patients With Atypical 

Hemolytic Uremic Syndrome (aHUS) Receiving Chronic Plasma Exchange/Infusion: Interim 


Analysis of a Phase II Study. 48 th European Renal Association (ERA) – European Dialysis and 

Transplant Association (EDTA), Prague, Czech Republic, June 23-26, 2011, Abstract Sa183, 

Poster Presentation. SRI 

135. Al Ghaithi BM, Langlois V, Hebert D, Harvey E, Licht C, Robinson LA: Case Study: An 

Unusual Cause of Graft Dysfunction After Renal Transplantation in a Child. 6 th Congress of the 

International Pediatric Transplant Association (IPTA), Montreal, Quebec, June 25-28, 2011. 

Pediatr. Transplantation, 2011: 15, Suppl. 1: 113, Abstract 297, Poster. C 

136. Licht C, Muus P, Legendre C, Douglas K, Hourmant M, Delmas Y, Herthelius M, Trivelli A, 

Goodship T, Bedrosian CL, Loirat C. A phase II study of eculizumab in patients with atypical 

hemolytic uremic syndrome (aHUS) receiving chronic plasma exchange/infusion: interim 

analysis. 23 rd Congress of the International Society on Thrombosis and Haemostasis (ISTH), 

Kyoto, Japan, July 23–28, 2011, Poster. PA 

PRESENTATIONS 

Invited Lectures, Seminars & Symposia: 

1. Die Rolle des Endothelin B-Rezeptors für die Entstehung der hypokaliaemischen Nephropathie. 

(Role of the endothelin B-receptor for the development of hypokalemic nephropathy.) 

Medizinische Klinik (Nephrologie) der Kliniken der Stadt Köln, Köln, Germany, November 14, 

2002. 

2. Die Rolle des Endothelin B-Rezeptors für die Entstehung der hypokaliaemischen Nephropathie. 

(Role of the endothelin B-receptor for the development of hypokalemic nephropathy.) 

Medizinische Klinik mit Schwerpunkt Nephrologie, Institut für Physiologie, Institut für 

Pharmakologie und Toxikologie, Institut für Anatomie, Campus Charite Mitte, 

Universitätsklinikum, Universität zu Berlin, Berlin, Germany, December 12, 2002. 

3. Role of endothelin-1/endothelin B receptor in the development of tubulointerstitial fibrosis in 

chronic hypokalemia. Klinik und Poliklinik für Dermatologie und Venerologie der Universität zu 

Köln, Köln, Germany, January 24, 2003. 

4. Das idiopathische (primäre) nephrotische Syndrom. [Idiopathic (primary) nephrotic syndrome.] 

Zentrum für Kinderheilkunde und Jugendmedizin der Universität zu Köln, Kinderärztlicher 

Nachmittag, Köln, Germany, January 29, 2003. 

5. Ethisches Konsil in der Neonatologie. (Ethics counseling in Neonatology.) Diözesan- 

Caritasverband für das Erzbistum Köln e.V., Psychosoziale Beratung vor, während und nach 

Pränataldiagnostik, Bensberg, Germany, June 4-5, 2003. 

6. Atypisches hämolytisch-urämisches Syndrom (D-). [Atypical hemolytic uremic syndrome (D-).] 

Rheinisch-Westfälisches Nephrologisches Seminar für Kinderärzte, Mülheim, Germany, January 

16-18, 2004. 

7. Die Rolle der ET-1/ETB-Rezeptor Interaktion bei der Vermittlung der renalen tubulointerstitiellen 

Fibrose. (Role of the ET-1/ETB-receptor interaction in mediating renal tubulointerstitial fibrosis.) 

Kinderklinik der Universität Heidelberg, Sektion Pädiatrische Nephrologie, Heidelberg, Germany, 

March 4, 2004. 

8. Faktor H-Mangel und aHUS/MPGN II. (Factor H deficiency and aHUS/MPGN II.) Zentrum für 


Kinderheilkunde und Jugendmedizin der Universität Freiburg, Pädiatrische Nephrologie, Freiburg, 

Germany, May 4, 2004. 

9. Neue Aspekte zum hämolytisch-urämischen Syndrom: Komplementregulationsstörung und 

Endothelläsion. (Novel aspects of hemolytic uremic syndrome: complement dysregulation and 

endothelial cell lesion.) Zentrum für Innere Medizin (Innere Medizin I) der Universität zu Köln, 

Köln, Germany, June 8, 2004. 

10. Verdachtsdiagnose Purpura Schönlein-Henoch (PSH). [Suspected diagnosis Henoch Schönlein 

Purpura (HSP).] Zentrum für Kinderheilkunde und Jugendmedizin der Universität zu Köln, 

Kinderaerztlicher Nachmittag, Köln, Germany, September 8, 2004. 

11. Atypical HUS and MPGN II as a result of Factor H deficiency: pathogenesis, diagnosis, and 

therapeutic options. Department of Paediatrics, Division of Nephrology, The Hospital for Sick 

Children, Toronto, Ontario, November 29–December 1, 2004. 

12. Neues zur Diagnostik und Therapie der MPGN II. (News regarding diagnosis and therapy of 

MPGN II.) Rheinisch-Westfälisches Nephrologisches Seminar für Kinderärzte, Köln, Germany, 

January 28-29, 2005. 

13. Purpura Schönlein-Henoch. (Henoch Schönlein Purpura.) Rheinisch-Westfälisches 

Nephrologisches Seminar für Kinderärzte, Köln, Germany, January 28-29, 2005. 

14. Faktor H – oder wenn das eigene Blut die Niere krank macht. (Factor H – or when your own blood 

causes renal disease.) Tag der Gesundheitsforschung, Köln, Germany, February 20, 2005. 

15. Deletion of one amino acid (K224) in the regulatory domain of Factor H reveals a novel 

pathomechanism for MPGN II. 2 nd International Workshop on Thrombotic Microangiopathies, 

Jena, Germany, May 27-28, 2005. 

16. Neue Therapieoptionen der Proteinurie. (Novel therapeutic options of proteinuria.) Zentrum für 

Kinderheilkunde und Jugendmedizin der Universität zu Köln, Kinderärztlicher Nachmittag, Köln, 

Germany, January 25, 2006. 

17. MPGN II – Challenges in treating the newly diagnosed patient and the transplant recipient. What 

are the best guidelines? 2 nd DDD/MPGN II Focus Group Meeting: Hinxton Retreat, Cambridge, 

England, August 18-20, 2006. 

18. Complement based glomerular diseases: from bedside to bench – and back. Canadian Association 

of Pediatric Nephrology (CAPN), San Diego, California, November 17, 2006. 

19. Non Shiga Toxin-Associated HUS: Clinics – Round Table: Perspectives on Research and 

Therapeutic Strategies, Collaborative Networks, and Funding, 2 nd Bergamo Workshop on 

Hemolytic Uremic Syndrome, Bergamo, Italy, November 30–December 1, 2006. 

20. MPGN Type II/DDD. Ophthalmology Rounds, Division of Nephrology, The Hospital for Sick 

Children, Toronto, Ontario, February 23, 2007. 

21. Komplementbasierte Nierenerkrankungen. (Complement-based renal diseases.) Georg-August- 

Universität Göttingen, Göttingen, Germany, March 21, 2007. 

22. Complement-based renal diseases. Gender Meeting, Division of Nephrology, Toronto General 

Hospital, April 25, 2007. 

23. Treatment of MPGN II/DDD – A Complement Centered Approach. Midwest Pediatric 

Nephrology Consortium (MWPNC) Spring 2007 Meeting, Cincinnati, Ohio, April 27-28, 2007. 


24. Microvasculopathy: Atypical HUS and Factor H Mutations. Canadian Society of Nephrology 

Annual Meeting, Review Course and Scientific Symposia, Halifax, Nova Scotia, May 23-27, 2007. 

25. Genetics of MPGN. 3 rd International Workshop Thrombotic Microangiopathies, Jena, Germany, 

October 4-6, 2007. 

26. A Molecular Pathogenesis-Driven Approach to Diagnosis and Treatment of Complement-Based 

Renal Diseases. Midwest Pediatric Nephrology Consortium (MWPNC) Fall 2007 Meeting, 

Detroit, Michigan, October 12-13, 2007. 

27. Genetics of MPGN. McMaster Children's Hospital, Hamilton, Ontario, October 17, 2007. 

28. Liver TX for Patients with Complement Based Renal Diseases (eg. Factor H Deficiency). GI 

Transplant Team Meeting, The Hospital for Sick Children, Toronto, Ontario, November 14, 2007. 

29. Complement Based Renal Diseases – A Translational Multidisciplinary Effort at SickKids. 

Clinical Biochemistry Rounds, Division of Nephrology, The Hospital for Sick Children, Toronto, 

Ontario, December 5, 2007. 

30. Atypical Hemolytic Uremic Syndrome – From Bench to Bedside. Haematology Section Rounds, 

The Hospital for Sick Children, Toronto, Ontario, April 1, 2008. 

31. The Spectrum of Complement-Based Kidney Diseases. City Wide Rounds, Nephrology Academic 

Program, University of Toronto, Toronto, Ontario, April 9, 2008. 

32. Advances in Evaluation and Management of Complement-Based Renal Diseases: MPGN Type II 

and Atypical HUS. PAS/ASPN 2008 Annual Meeting, Honolulu, Hawaii, May 3-6, 2008. 

33. KidCOM Study: A Molecular Pathogenesis-Driven Approach to Diagnosis and Treatment of 

Complement-Based Renal Diseases. Midwest Pediatric Nephrology Consortium (MWPNC) Fall 

2008 Meeting, Grand Rapids, Michigan, October 17-18, 2008. 

34. Program for complement-based renal diseases at SickKids. Gender Meeting, Division of 

Nephrology, Toronto General Hospital, November 26, 2008. 

35. SLE and Drusen. Divisional Rounds, Toronto Western Hospital, Toronto, Ontario, November 27, 

2008. 

36. Atypisches Hämolytisch-Urämisches Syndrom (aHUS) und Faktor H. [Atypical hemolytic uremic 

syndrome (aHUS) and Factor H.] Universitätsklinikum Heidelberg, Institut für Immunologie, 

Heidelberg, Germany, March 24, 2009. 


Complement-Based Renal Diseases. Midwest Pediatric Nephrology Consortium (MWPNC) 

Spring 2009 Meeting, Charlotte, North Carolina, April 16-17, 2009. 

38. Complement-based kidney diseases; Novel clues to old diseases. CHEO Pediatric Grand Rounds, 

Ottawa, Ontario, April 29, 2009. 

39. Prevention of CKD in patients with disorders of the complement system. Prevention in Renal 

Disease, 8 th Annual Conference, Toronto, Ontario, September 25-26, 2009. 

40. Komplementbasierte Nierenerkrankungen. (Complement-based renal diseases.) Kinderklinik der 

Universität Hamburg, Hamburg, Germany, October 7, 2009. 

41. MPGN. 1 st Workshop: Sporadische und angeborene Glomerulopathien in der pädiatrischen 

Nephrologie. (1 st workshop: Sporadic and congenital glomerulopathies in pediatric nephrology), 

Bergisch-Gladbach, Germany, October 9-10, 2009. 



Complement-Based Renal Diseases – Update. Midwest Pediatric Nephrology Consortium 

(MWPNC) Fall 2009 Meeting, Indianapolis, Indiana, October 16-17, 2009. 

43. Complement Regulatory Protein Deficiency in Thrombotic Microangiopathies. Renal Week 2009, 

San Diego, California, October 27–November 1, 2009. 

44. Complement-based renal diseases – an update. The Child Health Research Center Speaker Series. 

The Research Institute at Nationwide Children‟s Hospital, Columbus, Ohio, January 28-29, 2010. 

45. Kidneys – Clots – and Complement: How Understanding Platelets Helps Children with Renal 

Failure. 2 nd Annual IMS Open House, Institute of Medical Science, University of Toronto, 

Toronto, Ontario, February 20, 2010. 

46. Hämodialyse bei Kindern – Grundlagen, Optimierung der Ultrafiltration. (Hemodialysis in 

children – basics, optimization of ultrafiltration.) 2. Symposium für Pflegekräfte in der 

pädiatrischen Nephrologie (2 nd Symposium for Nurses in Pediatric Nephrology), Universität 

Hamburg, Hamburg, Germany, March 25-27, 2010. 

47. Atypical HUS: Current and Future Direction. 1 st Annual Pediatric Nephrology Symposium, King 

Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia, April 6-7, 2010. 

48. New Therapeutic Modalities in Management of aHUS. 1 st Annual Pediatric Nephrology 

Symposium, King Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi 

Arabia, April 6-7, 2010. 

49. Outcome of Renal Transplantation in aHUS. 1 st Annual Pediatric Nephrology Symposium, King 

Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia, April 6-7, 2010. 

50. Antenatal hydronephrosis. Department of Paediatrics, Paediatric Update Conference, Toronto, 

Ontario, April 12-17, 2010. 

51. New Therapies for Membranoproliferative Glomerulonephritis. PAS/ASPN 2010 Annual 

Meeting, Vancouver, British Columbia, May 1-4, 2010. 

52. Pathogenesis of atypical HUS – at the interface of coagulation and immunity. Alberta Children's 

Hospital/University of Calgary, Calgary, Alberta, July 16, 2010. 

53. Pharmaceutical Treatment of Alport Syndrome. 15 th Congress of the International Pediatric 

Nephrology Association (IPNA 2010 Congress), New York, New York, August 29–September 2, 

2010. 

54. Novel Approaches To aHUS: Targeting C5a. 15 th Congress of the International Pediatric 

Nephrology Association (IPNA 2010 Congress), New York, New York, August 29–September 2, 

2010. 

55. MPGN – Neue Therapieansätze. (MPGN – New therapeutic approaches.) 2 nd Workshop: 

Sporadische und angeborene Glomerulopathien in der pädiatrischen Nephrologie (2 nd workshop: 

Sporadic and congenital glomerulopathies in pediatric nephrology), Pinneberg, Germany, 

September 24-25, 2010. 

56. (i) MPGN Prospective Study; (ii) KidCOM – Update. Midwest Pediatric Nephrology Consortium 

(MWPNC) Fall 2010 Meeting, Milwaukee, Wisconsin, October 1-2, 2010. 

57. Looking Forward by Looking Back: A Paediatric Dialysis Program Review. Canadian Association 

of Nephrology Nurses & Technologists (CANNT 2010) – Our Mosaic of Renal Care, Toronto, 


Ontario, November 18-20, 2010. 

58. At the intersection of coagulation and complement – novel aspects of aHUS pathogenesis. Renal 

Bipartite Meeting, UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS 

Trust, London, England, December 9, 2010. 

59. Complement-Mediated Nephropathies. Alexion Pharmaceuticals Inc., Cheshire, Connecticut, 

March 22, 2011. 

60. Die Niere: Bedeutung und Funktionsweise, Erkrankungen und Therapien im Alter (The Kidney: 

Role and Function, Diseases and Therapies in the Elderly). Bildungszentrum Karlsruhe – 

Bildungswerk der Erzdiözese Freiburg; Akademie der Älteren Generation Karlsruhe (Center for 

Continued Education Karlsruhe – Institution for Continued Eductaion of the Archdiocese Freiburg; 

Academy of the Senior Generation Karlsruhe), Karlsruhe, Germany, April 11 2011. 

61. Alternative Pathway Activation: The Renal Perspective. Autoimmunity & Inflammation Cross 

Talk Series “The Comeback of the Complement Pathway”, The Hospital for Sick Children, 

Toronto, Ontario, May 12, 2011. 

62. Eculizumab Clinical Trial Development in aHUS. aHUS Expert Panel, Alexion Pharmaceuticals 

Inc., Amsterdam, The Netherlands, May 20, 2011. 

63. Therapy of MPGN – a case for complement. 3 rd International Conference: HUS & MPGN & 

related diseases, Innsbruck, Austria, May 22-24, 2011. 

64. Has Eculizumba Revolutionized the Management of Renal Transplantation in Atypical Hemolytic 

Uremic Syndrome? 6 th Congress of the International Pediatric Transplant Association (IPTA), 

Montreal, Quebec, June 25-28, 2011. 

65. Eculizumab and Terminal Complement Inhibition as a Therapeutic Strategy in aHUS. 23 rd 

Congress of the International Society on Thrombosis and Haemostasis (ISTH), Kyoto, Japan, 

July 23–28, 2011. 

HONOURS AND CAREER AWARDS 

Distinctions, Research, and Other Awards: 

Distinctions 

2006 Fellow of the American Society of Nephrology (FASN) 

2007 Appointed Member of the European Pediatric Research Group for HUS 

2007 Appointed Associate Member of the European Working Party for the Genetics of Complement 

Based Diseases 

2008 Appointed Steering Committee Member of the Alport Syndrome Treatments and Outcomes 

Registry (ASTOR) 

2009 Appointed Member of the European DEAP-HUS Study Group 

2010 Appointed Member of the Safety Board of the European Treatment Trial for Alport Syndrome 

2011 Appointed Member of The Canadian Kidney Knowledge Translation and Generation Network 

(CANN-NET) 


Research Awards 

2002 First Prize, National Kidney Foundation's Research Fellow and Young Investigators Research 

Presentation, Clinical Nephrology Meetings, Chicago, Illinois 

2004 Else-Kröner-Fresenius (best poster award), Working Group for Pediatric Nephrology, Mainz, 

Germany 

Other Awards – Student/Trainee 

2007 CAPN Trainee Research Award to Dr. Aoife Waters for project entitled Deficiency of FHR- 

1/FHR-3 causes atypical hemolytic uremic syndrome from the Canadian Association of 

Pediatric Nephrology 

2007 Blue Ribbon Award to Dr. Aoife Waters for oral presentation entitled Deficiency of FHR- 

1/FHR-3 causes atypical hemolytic uremic syndrome at the 14 th Congress of the International 

Pediatric Nephrology Association 

2007 Blue Ribbon Award to Dr. Rajesh Krishnan for oral presentation entitled Phenotypical 

relevance of the Y402 mutations of factor H in children with complement based MPGN 

II/DDD and aHUS at the 14 th Congress of the International Pediatric Nephrology Association 

2008 NSERC best research article award to Ms. Nicole Choi, Research Student for results of 

research published in Journal of Undergraduate Life Sciences (JULS, 2009: 3: 1: 40-3) entitled 

Intracellular localization and release of platelet vascular endothelial growth factor 

PROFESSIONAL AFFILIATIONS AND ACTIVITIES 

Professional Associations: 

� American Society of Nephrology (1999) 

� American Society of Pediatric Nephrology (2009) 

� Canadian Association of Pediatric Nephrology (2006) 

� Deutsche Gesellschaft für Kinderheilkunde und Jugendmedizin, Germany (1992) 

� Deutsche Gesellschaft für Nephrologie, Germany (2006) 

� Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin, Germany (1994) 

� Gesellschaft für Pädiatrische Nephrologie, Germany (1998) 

� International Pediatric Nephrology Association (1998) 

� International Society of Nephrology (1999) 

Peer Review Activities: 

Editorial Boards 

2008– Nephrology Dialysis Transplantation – Subject Editor „Pediatric Nephrology‟ 

2009– Pediatric Nephrology – Section Editor „Immunology/Glomerular Disease‟ 

2010– Journal of Blood Disorders & Transfusion 

Grant Reviews 

2006 Internal Grant and Promotion Peer-Review Panels, The Hospital for Sick Children and 

SickKids Research Institute 


2007 Instituto Superiore di Sanita – Italy 

2009 Kidney Research UK External Referee Panel – UK 

2009 Tiroler Wissenschaftsfonds (TWF) – Austria 

2009 Action Medical Research – UK 

2011 Medical Research Council – UK 

2011 Wellcome Trust – UK 

Scientific Journal/Manuscript Reviews 

� American Journal of Kidney Diseases 

� American Journal of Nephrology 

� American Journal of Transplantation 

� Annals of Transplantation 

� Archives of Disease in Childhood 

� Biochimica et Biophysica Acta (BBA) – Molecular Cell Research 

� Blood 

� Clinical Journal of the American Society of Nephrology 

� European Journal of Human Genetics 

� Expert Opinion on Pharmacotherapy 

� Human Mutation 

� Journal of Pediatric Intensive Care 

� Journal of Rheumatology, The 

� Journal of the American Society of Nephrology 

� Kidney International 

� Molecular Biotechnology 

� Nature Reviews Nephrology 

� Nephrology Dialysis Transplantation 

� New England Journal of Medicine, The 

� Pediatric Nephrology 

� Thrombosis and Haemostasis 

� World Journal of Pediatrics 

Academic Committees/Panels 

National and International Activities: 

2006 Else-Kröner-Fresenius award prize committee, 37 th Annual Meeting of the German Working 

Group for Pediatric Nephrology, Marburg, Germany 

2011 Else-Kröner-Fresenius award prize committee, 42 nd Annual Meeting of the German Working 

Group of Pediatric Nephrology, Bamberg, Germany 

The Hospital for Sick Children Research Institute Activities: 

2011 Committee Member, SickKids Research Training Centre – Trainee Start up Fund Program 

(TSUF) 

2011 Poster judging, 2011 Summer Student Research (SSuRe) Program, SSuRe Symposium Day 

University of Toronto Activities: 


2010 Poster judging, Alan Wu Poster Competition, IMS Scientific Day, University of Toronto 

2011 Poster judging, LMP Graduate Student Research Day (GSRD), University of Toronto 

ACADEMIC HISTORY 

RESEARCH AWARDS (Peer- and Non Peer-Reviewed) 

Grants – Currently Funded: 

2010 Alexion Pharmaceuticals, Inc., Cheshire, Connecticut 

Title: Control of complement-mediated platelet activation in aHUS via Eculizumab. 

Principal Investigator: Dr. Christoph Licht 

Awarded: $15,000 USD 

2009–12 Heart and Stroke Foundation of Ontario (HSFO) 

Grant #: NA 6716 

Title: Atypical Hemolytic Uremic Syndrome: A New Pathological Role for Complement and 

Coagulation Control in Platelets. 


Co-Investigator: Dr. Walter H. A. Kahr 

Awarded: $96,901 CND / year (Total: $290,704 CND over 3 years) 

[Application ranked nationally “excellent” (8/47)] 

Grants – Previously Funded: 

2002 Imhoff-Stiftung, University of Cologne, Cologne, Germany 

Grant #: 93/2002 

Title: Untersuchung der Genregulation des renalen Kortex von Endothelin B (ETB)-Rezeptor 

Wildtyp- und knock out-Mäusen im Modell der chronischen Hypokolämie mittels Microarray- 

Analyse. [Microarray analysis of the gene regulation in the renal cortex of endothelin B (ETB) 

receptor wild type and knock out mice in chronic hypokalemia.] 


Awarded: €5,214 = ~$8,000 CND 

2004 Maria-Pesch-Stiftung, University of Cologne, Cologne, Germany 

Grant #: 56/2004 

Title: Klinische und molekularbiologische Charakterisierung von funktionellen Faktor H- 

Defekten als neues pathogenetisches Prinzip für die Entstehung einer membranoproliferativen 

Glomerulonephritis Typ II (MPGN II=dense deposit disease). [Clinical and molecular 

characterization of functional Factor H defects as new pathogenetic principal for the 

development of Membranoproliferative Glomerulonephritis Type II (dense deposit disease).] 


Awarded: €4,700 = ~$7,500 CND 

2006–08 SickKids Research Institute, Start-up Operating Fund 

Title: The Interface of the Complement and the Coagulation System in Patients with aHUS 


Awarded: $70,000 CND / year (Total: $140,000 CND over 2 years) 

2009 The Foundation for Children with Atypical HUS 

Title: KidCOM-Study 



Awarded: $5,000 CND 

2009–11 American Society of Nephrology 2009 Norman Siegel Research Scholar Grant 

Title: Atypical Hemolytic Uremic Syndrome: A New Pathological Role for Complement and 

Coagulation Control in Platelets. 


Awarded: $100,000 USD / year (Total: ~$202,450 CND over 2 years) 

Grants – Requested: 

2011 NIH Exploratory/Developmental Research Grant Award (R21) 

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 

Title: Multi-center Controlled Clinical Trials in Alport Syndrome - A Feasibility Study 

Co-applicant: Dr. Christoph Licht 

Principal Investigator: Dr. Clifford E. Kashtan, University of Minnesota 

Requested: $47,898 USD (over 2 years) 

Clinical Trials – Currently Funded: 

2009–10 Alexion Pharmaceuticals, Inc., Cheshire, Connecticut 

Title: An open-label, multi-center controlled clinical trial of Eculizumab in adolescent patients 

with plasma therapy sensitive atypical hemolytic-uremic syndrome (aHUS) 

Principal Investigator: company sponsored trial 

Awarded: $20,872 USD (26 week treatment protocol) + $10,426 USD (26 week extension 

phase) per enrolled patient = ~$32,880 CND per enrolled patient 

2009–12 ASTOR Study – University of Minnesota 

Title: Alport Syndrome Treatments and Outcomes Registry (ASTOR). A Prospective Study of 

Microalbuminuria in Untreated Boys with Alport Syndrome 

Principal Investigator (Local): Dr. Christoph Licht 

Principal Investigator: Dr. Clifford E. Kashtan, University of Minnesota 

Awarded: $12,000 USD = ~$13,164 CND / year 

(Total: $36,000 USD = ~$39,500 CND over 3 years) 

Salary Support and Other Funding: 

Personal Salary Support 

1999 Köln-Fortune, University of Cologne, Cologne, Germany 

Grant #: KF 43/1999 

Title: Einfluß von Endothelin 1 auf Transportprozesse am Epithel des proximalen 

Nierentubulus: Urinansäuerung und Phosphatausscheidung. (Role of endothelin-1 for transport 

processes of proximal tubular epithelial cells: urine acidification and phosphate excretion.) 

Awarded: €19,649 = ~$30,000 CND 

2000–02 NKF Fellowship Grant, National Kidney Foundation 

Awarded: $30,000 USD = ~$44,500 CND / year 

(Total: $60,000 USD = $89,000 CND over 2 years) 

2003 Köln-Fortune, University of Cologne, Cologne, Germany 

Grant #: 153/2003 

Title: Die Rolle der Endothelin-1 (ET-1) / Endothelin B (ETB)-Rezeptor Interaktion bei der 


Entstehung der tubulointerstitiellen Fibrose im Modell der Proteinurie. [The role of endothelin- 

1 (ET-1) / endothelin B (ETB) receptor interaction for the development of tubulointerstitial 

fibrosis in proteinuria.] 

Awarded: €65,800 = ~$100,000 CND 

Trainee Salary Support 

2009 SickKids Summer Research Program (SSuRe) Subsidy 


2010 University of Toronto Fellowship (UTF) Award from the 

Department of Laboratory Medicine and Pathobiology 

Awarded: $5,000 CND (2010–11 academic for Joshua Yuen) 

2011 SickKids Summer Research Program (SSuRe) Subsidy 


Patents: 

Applications Under Process 

[International #: WO 2007/038995 A1]; [U.S. #: 11/992,194]; [CSL Behring #: 2005_M006_A105]; 

[Finnegan #: 06478.1518-00000] 

Title: Factor H for the treatment of chronic nephropathies and production thereof 

RESEARCH SUPERVISORY EXPERIENCE/MENTORSHIP 

Postdoctoral Fellows: 

2009–10 Dr. Viola van Eimeren – Postdoctoral Fellow 

Co-supervisor: Dr. Walter Kahr 

Project 1: Comparative study of complement factors presence in platelets 

Project 2: The role of complement Factor H (CFH) in complement-mediated platelet 

activation 

Graduate Students – Masters: 

2010– Joshua Yuen – Graduate Student 

Co-supervisor: Dr. Nades Palaniyar 

University Department: Laboratory Medicine and Pathobiology (LMP) 

Project Title: Characterization of the complement system in neutrophils – possible role for the 

pathogenesis of atypical hemolytic uremic syndrome (aHUS) 

Support: Department of LMP, Univeristy of Toronto 2010–2011 Academic Award; Ontario 

Graduate Scholarship Program (OGS) (Sept/11–Aug/14) 

2011– Judith Gras – Graduate Student (Diploma, Germany) 

Project Title: Interaction partners for complement factor H in the process of neutrophil 

adhesion – possible role for the pathogenesis of atypical hemolytic uremic syndrome (aHUS) 

Undergraduate Students: 


Project Research Students 

2010–11 Jenny Zhao – Project Research Student (9 months) 

Project Title: The Role of Complement Factor H in Platelet Activiation 

Co-op Research Student 

2010 Antony Jeganathan – Co-op Research Student (8 months) 

Project Title: Apelin – a candidate gene for aHUS pathogenesis 

Summer Research Students 

2008 Nicole Choi – Summer Research Student (3 months) 

Project Title: Platelets as transporters of vascular endothelial growth factor: intracellular 

localization and release 

[Results of this research were published in Journal of Undergraduate Life Sciences (JULS, 

2009: 3: 1: 40-3) and received NSERC best research article award] 

2008 Michela Faggioni – International Summer Research Student (3 months) 

Project Title: Characterization of complement regulatory proteins in platelets 

2008 Rahul Mehrotra – Volunteer Summer Research Student (3 months) 

Project Title: Post infectious glomerulonephritis: re-interpretation as C3 deposition 

glomerulopathy? 

2009 Rahul Mehrotra – Summer Research Student (3 months) 

Project Title: Platelet-associated complement Factor H in normal individuals and patients with 

atypical HUS 

Support: SickKids Summer Research Program (SSuRe) 

2009 Shahzad Irani – Summer Student (3 months) 

Project Title: Updating Division of Nephrology databases (e.g. NAPRTCS) 

2010 Jenny Zhao – Summer Research Student (3 months) 

Project Title: CFH in platelets – implications for aHUS pathogenesis 

2010 Ozge Gonul – International Summer Research Student (2 months) 

Project Title: Pathological Significance of Complement Factor H Mutations in Atypical 

Hemolytic Uremic Syndrome 

2011 Antony Jeganathan – Summer Research Student (5 months) 

Project Title: CFH binding partners in platelets 

Other: 

2002–04 Sabine Anderweit – Co-supervisor of Doctoral Thesis (Dr. med.) 

Co-supervisor: Dr. Bernhard Roth 

Title: Entscheidungsfindung in der Therapie schwerkranker Früh- und Neugeborener. 

(Decision making in the therapy of severely ill preterms and newborns.) 

2006–08 Andre Schael – Supervisor of Doctoral Thesis (Dr. med.) 

Title: Untersuchung zur Rolle von ET-1 und TGF-b bei der epithelial-mesenchymalen 

Transdifferenzierung proximaler Tubulusepithelzellen der Niere. (Investigations of the role of 

ET-1 and TGF-b for the epithelial-mesenchymal transdifferentiation of proximal tubule 

epithelial cells of the kidney.) 

2006–08 Catherine Niederkorn – Supervisor of Doctoral Thesis (Dr. med.) 


TEACHING 

Title: Langzeitverlauf nach HUS – Nachuntersuchung von Patienten der 

Universitätskinderklinik Köln. (Long-term outcome after HUS – follow-up on patients of the 

Childrens Hospital of the University of Cologne.) 

Lectures, Courses, and Workshops Presented at Universities/ Organizations: 

Academic Year, 2006–07 

� Complement Based Renal Diseases. Division of Nephrology Lecture Series, The Hospital for Sick 

Children, Toronto, Ontario, September 11, 2006. 

� Novel Treatment Options for Complement Based Renal Diseases. Division of Nephrology 

Academic Rounds, The Hospital for Sick Children, Toronto, Ontario, January 9, 2007. 

� Proteinuria and Chronic Kidney Disease. Division of Nephrology Lecture Series, The Hospital for 

Sick Children, Toronto, Ontario, March 12, 2007. 


� Antenatal Hydronephrosis. MSc Degree Program in Genetic Counselling: Concepts in Clinical 

Genetics (MMG 1226Y), University of Toronto, Toronto, Ontario, November 7, 2007. 

� Proteinuria and Chronic Kidney Disease. Division of Nephrology Lecture Series, The Hospital for 

Sick Children, Toronto, Ontario, January 28, 2008. 

� Complement Pathways and Kidney Disease. IMS Seminar Series: GN Course Bench to Bedside 

(MSC 1084H), University of Toronto, Toronto, Ontario, February 13, 2008. 

� Complement-Based Renal Diseases. Division of Nephrology Lecture Series, The Hospital for Sick 

Children, Toronto, Ontario, April 28, 2008. 

� HUS/TTP – From Bench to Bedside. Hematology Section Rounds, Division of 

Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, June 17, 2008. 


� Alport Syndrome and Thin Basement Membrane Nephropathy. University of Cologne, Cologne, 

Germany, July 14, 2008. 

� Vesicoureteral Reflux. Division of Nephrology Lecture Series, The Hospital for Sick Children, 

Toronto, Ontario, October 27, 2008. 

� Membranous Nephropathy. Division of Nephrology Lecture Series, The Hospital for Sick 

Children, Toronto, Ontario, December 1, 2008. 


Genetics (MMG 1226Y), University of Toronto, Toronto, Ontario, January 14, 2009. 

� Alport Syndrome and Thin Basement Membrane Nephropathy. Division of Nephrology Lecture 

Series, The Hospital for Sick Children, Toronto, Ontario, June 5, 2009. 



� Hemolytic Uremic Syndrome. Division of Nephrology Lecture Series, The Hospital for Sick 

Children, Toronto, Ontario, November 16, 2009. 


Genetics (MMG 1226Y), University of Toronto, Toronto, Ontario, December 2, 2009. 

� Alport Syndrome and Thin Basement Membrane Nephropathy. Division of Nephrology Lecture 

Series, The Hospital for Sick Children, Toronto, Ontario, January 25, 2010. 

� Complement Pathways and Kidney Disease. IMS Seminar Series: GN Course Bench to Bedside 

(MSC 1084H), University of Toronto, Toronto, Ontario, February 10, 2010. 


� Alport Syndrome. University of Cologne, Cologne, Germany, July 23, 2010. 


Genetics (MMG 1226Y), Molecular Genetics, University of Toronto, Toronto, Ontario, January 6, 

2011. 

� Vesicoureteral Reflux and Obstructive Genitourinary Disorders. Division of Nephrology Lecture 

Series, The Hospital for Sick Children, Toronto, Ontario, May 30, 2011.

Christoph Licht - Oxford Journals

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