Charlot Biosciences - Customer Brochure
Charlot Biosciences is commercializing innovative physics to study life. We are introducing a novel live cell analysis platform to the world of cell sorting and analysis. The technology is called cellPhoresis™. The Technology: Our platform has the unique ability to rapidly fractionate and sort cells based on biophysical properties.allowing researchers to study important differences between living cells only identifiable with genetic sequencing or protein sequencing. Being an agnostic approach to cell separation, we can support wide range of applications ranging from CRISPR gene editing verification, drug discovery for diseases like cancer and Alzheimer’s, and diagnostic assay development. The technology is backed by exclusive IP from ASU, Cal-Tech, and Charlot Biosciences. The platform separates cells based on inherent biophysical properties (external properties as well as internal structure and content). This approach enables the identification of important differences between live cells without labeling or destructive alteration. This benefit saves labs both time and money. The technology has already been validated in rapid pathogen identification and used for tracking human embryonic stem cell differentiation into various neural populations. Our interested partners have cited the value our cellPhoresis™ platform provides to develop new classes of molecular assays that help researchers and pharmaceutical companies screen for unintended side effects of gene therapy. Our affordable technology also enables enrichment of cells based on functional differences prior to nucleic acid purification and NGS. This approach enables faster discover of new biomarkers associated with complex disease.
Charlot Biosciences is commercializing innovative physics to study life. We are introducing a novel live cell analysis platform to the world of cell sorting and analysis. The technology is called cellPhoresis™.
The Technology:
Our platform has the unique ability to rapidly fractionate and sort cells based on biophysical properties.allowing researchers to study important differences between living cells only identifiable with genetic sequencing or protein sequencing. Being an agnostic approach to cell separation, we can support wide range of applications ranging from CRISPR gene editing verification, drug discovery for diseases like cancer and Alzheimer’s, and diagnostic assay development.
The technology is backed by exclusive IP from ASU, Cal-Tech, and Charlot Biosciences. The platform separates cells based on inherent biophysical properties (external properties as well as internal structure and content). This approach enables the identification of important differences between live cells without labeling or destructive alteration. This benefit saves labs both time and money.
The technology has already been validated in rapid pathogen identification and used for tracking human embryonic stem cell differentiation into various neural populations. Our interested partners have cited the value our cellPhoresis™ platform provides to develop new classes of molecular assays that help researchers and pharmaceutical companies screen for unintended side effects of gene therapy. Our affordable technology also enables enrichment of cells based on functional differences prior to nucleic acid purification and NGS. This approach enables faster discover of new biomarkers associated with complex disease.
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Innovative Physics to Study Life<br />
Commercializing ‘First in Kind’ Live Cell Sequecing<br />
www.cbiosciences.com
<strong>Charlot</strong> <strong>Biosciences</strong> is a life science tools company equipping<br />
researchers and clinicians with tools to help them identify predictive<br />
signatures of disease.<br />
Our propriety cellPhoresis platform enables the study of living<br />
cells. Our technology identifies important differences between<br />
Normal and Abnormal living cells, preserves function, and retains<br />
usability for further study.<br />
Our Approach:<br />
Reduces the need to perform genetic analysis<br />
Eliminates inefficiency commonly associated with single<br />
cell analysis<br />
Identifies subcellular differences found within intact cells<br />
Our technology platform provides helpful solutions for<br />
CRISPR/CAS9 gene editing, study of the microbiome, stem cell<br />
research, and much more.<br />
CEO
How can we<br />
accelerate<br />
your research?
An Introduction to<br />
CRISPR Verification<br />
CRISPR is a gene editing technique used to reprogram how living cells function.<br />
Example Applications:<br />
Program human immune cells to target and destroy cancer cells<br />
Program all human cells stop or even reverse aging<br />
Modify plant cells to remove excess greenhouse gasses like methane and CO<br />
Modify algae to produce more biofuel<br />
Modify yeast cells to enhance flavor profile in beer and wine<br />
2<br />
A promising technique with a massive verification problem<br />
(Current QC methods are expensive and require cell destruction to confirm reprogramming)
Cost-Effective Solution<br />
Companies can save more than $100k/year in recurring costs to study single cells.<br />
CRISPR Verification<br />
Existing Solution (>$150K)<br />
Next Generation Sequencing, Mass Spectroscopy,<br />
Fluorescence Microscopy, Flow Cytometry<br />
Our Solution (
cellPhoresis<br />
High resolution separation of cells based on their inherent biophysical properties. cellPhoresis<br />
combines the power of cytometry and electrophoresis within a micro channel. The technology<br />
exploits high resolution insulating gradient dielectrophoresis to provide researchers the<br />
ability to perform gel-free electrophoretic separation of cells. This approach is akin<br />
to gradient gel electrophoresis for cells and other biomolecules without the<br />
fuss. cellPhoresis is gel-free electrophoretic<br />
cytometry powered by electricity.<br />
Amazing what a little charge can do!<br />
Vision<br />
A multifunciontal platform for every lab.<br />
<strong>Charlot</strong> <strong>Biosciences</strong>' Vision platform brings<br />
solid-state optics with outstanding sensitivity,<br />
maximum resolution, and zero pixel shift to all<br />
researchers.<br />
The system streamlines filtration, refinement, and<br />
quantification of biomolecules directly from<br />
physiological samples.<br />
Rapid Detection<br />
of Pathogens<br />
Characterization<br />
of Stem Cells<br />
Isolation of<br />
Exosomes<br />
Sorting of<br />
Nanoparticles<br />
Antibiotic Resistance<br />
and Lyme Disease<br />
ImmunoTherapy<br />
and Drug Discovery<br />
Diabetes, Inflammatory<br />
Disease, Oncology<br />
NGS, Drug Delivery<br />
Research, Basic Science
How It Works<br />
CRISPR Verification<br />
cellPhoresis 8-Channel<br />
Launching Q3 2018<br />
We will save companies time<br />
and recurring costs to validate<br />
gene editing.<br />
We verify all of the edited cells.<br />
A New Form of Biophysical Analysis<br />
Life Science<br />
(Dynamically track live cell activity)<br />
Verifiable predictive power<br />
Identify and track side effects<br />
V2 - The verification cohort of cells can be used for therapy or additional testing.<br />
Cells are alive, viable, and<br />
useful for therapy
<strong>Charlot</strong> <strong>Biosciences</strong><br />
5171 California Avenue<br />
Irvine, CA 92617<br />
www.cbiosciences.com<br />
cbiosciences c_biosciences cbiosciences
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