SzSA YearBook 2016/17

SZENT-GYÖRGYI JUNIOR MENTORS
DÉNES ZÁDORI
Department of Neurology,
University of Szeged
Address: Semmelweis u. 6., H-6725 Szeged, Hungary
E: zadori.denes@med.u-szeged.hu
T: +36 62/545-348
RESEARCH AREA
In recent years increasing attention has been paid to
neuroscience research, because the pathomechanism of
neurological disorders with high socioeconomic burden is
only partially revealed and in most cases the therapeutic
possibilities are restricted as well. The aim of our studies is
to find metabolic alterations with possible prognostic or
therapeutic significance via the bioanalytical assessment
of certain metabolites (e.g., compounds of the kynurenine
pathway of the tryptophan metabolism, antioxidants, some
neurotransmitters) from biological samples of neurological
patients (e.g., suffering from migraine, pain, stroke, Alzheimer’s
disease and other neurocognitive disorders, multiple
sclerosis, Parkinson’s disease, Huntington’s disease, and
disorders accompanied with ataxia) or from samples obtained
from their experimental models.
TECHNIQUES AVAILABLE IN THE LAB
Induction of neurodegeneration in animals by certain
toxins (sodium azide, 1-methyl-4-phenyl-1,2,3,6-tetrahydro
pyridine, 3-nitropropionic acid), the preparation of
serum, cerebrospinal fluid and nervous system samples for
bioanalytical procedures, HPLC (quantification of tryptophan
metabolites, tocopherols, biogenic amines, GABA and
glutamate with UV, fluorescent or electrochemical detectors),
ELISA (quantification of beta-amyloid, tau and phospho-tau),
spectrophotometry and nephelometry.
SELECTED PUBLICATIONS
Veres, G., Fejes-Szabó, A., Zádori, D., Nagy-Grócz, G., László,
M.A., Bajtai, A., Mándity, I., Szentirmai, M., Bohár, Z., Laborc,
K., Szatmári, I., Fülöp, F., Vécsei, L., Párdutz, Á. (2017) A
comparative assessment of two kynurenic acid analogs in
the formalin model of trigeminal activation: a behavioral,
immunohistochemical and pharmacokinetic study. J Neural
Transm 124: 99-112.
Veres, G., Molnár, M., Zádori, D., Szentirmai, M., Szalárdy,
L., Török, R., Fazekas, E., Ilisz, I., Vécsei, L., Klivényi, P.
(2015) Central nervous system-specific alterations in the
tryptophan metabolism in the 3-nitropropionic acid model
of Huntington’s disease. Pharmacol Biochem Behav 132:
115-124.
Zádori, D., Ilisz, I., Klivényi, P., Szatmári, I., Fülöp, F., Toldi,
J., Vécsei, L., Péter, A. (2011) Time-course of kynurenic acid
concentration in mouse serum following the administration
of a novel kynurenic acid analog. J Pharm Biomed Anal 55:
540-543.
Zádori, D., Nyiri, G., Szőnyi, A., Szatmári, I., Fülöp, F., Toldi,
J., Freund, T.F., Vécsei, L., Klivényi, P. (2011) Neuroprotective
effects of a novel kynurenic acid analogue in a transgenic
mouse model of Huntington’s disease. J Neural Transm
118: 865-875.
Zádori, D., Geisz, A., Vámos, E., Vécsei, L., Klivényi, P.
(2009) Valproate ameliorates the survival and the motor
performance in a transgenic mouse model of Huntington’s
disease. Pharmacol Biochem Behav 94: 148-153.
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