SzSA YearBook 2016/17
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SZENT-GYÖRGYI JUNIOR MENTORS<br />
SÁNDOR VALKAI<br />
Institute of Biophysics<br />
Biological Research Center of the<br />
Hungarian Academy of Sciences<br />
Address: Temesvári krt. 62., H-6725 Szeged, Hungary<br />
E: valkai.sandor@brc.mta.hu<br />
T: +36 62/599-600<br />
RESEARCH AREA<br />
We work on integrated optical devices combined with microfluidics<br />
(design, production and usage). We develop such<br />
a label-free integrated optical biosensor that is capable of<br />
detecting bacteria via antibody-antigene reaction. Chromoproteins<br />
(eg. Bacteriorhodopsin) are also studied in integrated<br />
optical devices as photoactive materials. We also<br />
develope a microfluidical model system for biological barriers<br />
(for example: blood-brain-barrier).<br />
TECHNIQUES AVAILABLE IN THE LAB<br />
Creating and designing microfluidical devices and integrated<br />
optical devices (consisting of optical waveguides). Skills<br />
for usual devices can be found in a Clean Room: mask aligner<br />
(standard i-line and g-line photolithography), a maskless<br />
photolithography machine, a spincoater with photoresists,<br />
a plasma cleaner. Use of an inverted optical microscope,<br />
diode lasers and photodetectors. Devices in microfluidics:<br />
syringe pumps, peristaltic pumps and work with the PDMS<br />
silicone elastomer.<br />
SELECTED PUBLICATIONS<br />
Walter, F.R., Valkai, S., Kincses, A., Petneházi, A., Czeller, T.,<br />
Veszelka, S., Ormos, P., Deli, M.A., Dér, A. (<strong>2016</strong>) A versatile<br />
lab-on-a-chip tool for modeling biological barriers. Sens<br />
Actuators B Chem 222: 1209-1219.<br />
Mathesz, A., Valkai, S., Sipos, O., Stercz, B., Kocsis, B., Szabo,<br />
D., Der, A. (2015) Integralt optikai szenzor biologiai mintak<br />
gyors analizisehez. Orvosi Hetilap 156: 2116-2119.<br />
Mathesz, A., Fabian, L., Valkai, S., Alexandre, D.,<br />
Marques, P.V.S., Ormos, P., Wolff, E.K., Der, A. (2013) Highspeed<br />
integrated optical logic based on the protein<br />
bacteriorhodopsin. Biosens Bioelectron 46: 48-52.<br />
Nagy, K., Sipos, O., Valkai, S., Gombai, É., Hodula, O.,<br />
Kerényi, Á., Ormos, P., Galajda, P. (2015) Microfluidic study<br />
of the chemotactic response of Escherichia coli to amino<br />
acids, signaling molecules and secondary metabolites.<br />
Biomicrofluidics 9: Paper 044105.<br />
Der, A., Valkai, S., Mathesz, A., Ando, I., Wolff, E.K., Ormos,<br />
P. (2010) Protein-based all-optical sensor device. Sens<br />
Actuators B Chem 151: 26-29.<br />
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