SzSA YearBook 2016/17
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SZENT-GYÖRGYI JUNIOR MENTORS<br />
MÁRTA JULIANNA SÁRKÖZY<br />
Metabolic Diseases and Cell Signalling Group (MEDICS)<br />
Department of Biochemistry, Faculty of Medicine,<br />
University of Szeged<br />
Address: Dóm tér 9., H-6720 Szeged, Hungary<br />
E: sarkozy.marta@med.u-szeged.hu<br />
martasarkozy@gmail.com<br />
T: +36 62/545-096<br />
RESEARCH AREA<br />
Cardiovascular diseases and especially acute myocardial<br />
infarction are the leading causes of morbidity and mortality<br />
in developed countries. Metabolic diseases including<br />
hyper cholesterolemia, diabetes mellitus, metabolic syndrome<br />
and chronic renal failure, are well known risk factors<br />
for cardiovascular diseases and their complications (e.g.<br />
diastolic dysfunction, left ventricular hypertrophy and fibrosis,<br />
heart failure, etc.). Our research group is interested in<br />
the investigation of molecular mechanisms playing a role in<br />
the development of acute myocardial infarction and cardiac<br />
complications of metabolic risk factors. Furthermore, we<br />
investigate myocardial adaptation to ischemia (i.e. ischemic<br />
preconditioning and postconditioning) in the presence or<br />
absence of metabolic risk factors. Our aim is to better understand<br />
the molecular mechanisms of heart diseases developing<br />
as a consequence of metabolic risk factors, and to<br />
discover possible new therapeutic strategies.<br />
TECHNIQUES AVAILABLE IN THE LAB<br />
Induction and treatment of disease models (hyperlipidaemia,<br />
diabetes mellitus, metabolic syndrome, chronic renal<br />
failure, radiation induced heart disease) in experimental<br />
animals, assessment of cardiac function and morphology<br />
by transthoracic echocardiography, surgical intervention<br />
to induce chronic renal failure, oral glucose tolerance test,<br />
Langendorff heart perfusion, induction of acute myocardial<br />
infarction, ischemic pre- and postconditioning, determination<br />
of infarct size, histological analysis, general biochemical<br />
methods (colorimetric assays, RT-PCR, ELISA, etc.) to determine<br />
metabolites (e.g. serum glucose, urea, creatinine, etc.),<br />
nucleic acids, proteins and enzyme activities (e.g. creatine<br />
kinase, lactate dehydrogenase, etc.).<br />
SELECTED PUBLICATIONS<br />
Sárközy, M., Szűcs, G., Fekete, V., Pipicz, M., Éder, K., Gáspár,<br />
R., Sója, A., Pipis, J., Ferdinandy, P., Csonka, C., Csont, T. (<strong>2016</strong>)<br />
Transcriptomic alterations in the heart of non-obese type<br />
2 diabetic Goto-Kakizaki rats. Cardiovasc Diabetol 15: 110.<br />
Kiscsatári, L., Sárközy, M., Kővári, B., Varga, Z., Gömöri, K.,<br />
Morvay, N., Leprán, I., Hegyesi, H., Fábián, G., Cserni, B.,<br />
Cserni, G., Csont, T., Kahán, Z. (<strong>2016</strong>) High-dose radiation<br />
induced heart damage in a rat model. In Vivo 30: 623-631.<br />
Sárközy, M., Szűcs, G., Pipicz, M., Zvara, Á., Éder, K., Fekete,<br />
V., Szűcs, C., Bárkányi, J., Csonka, C., Puskás, L.G., Kónya, C.,<br />
Ferdinandy, P., Csont, T. (2015) The effect of a preparation<br />
of minerals, vitamins and trace elements on the cardiac<br />
gene expression pattern in male diabetic rats. Cardiovasc<br />
Diabetol 15: 14:85.<br />
Sárközy, M., Zvara, A., Gyémánt, N., Fekete, V., Kocsis, G.F.,<br />
Pipis, J., Szűcs, G., Csonka, C., Puskás, L.G., Ferdinandy, P.,<br />
Csont, T. (2013) Metabolic syndrome influences cardiac<br />
gene expression pattern at the transcript level in male ZDF<br />
rats. Cardiovasc Diabetol 12: 16.<br />
Kocsis G.F., Sárközy, M., Bencsik, P., Pipicz, M., Varga,<br />
Z.V., Pálóczi, J., Csonka, C., Ferdinandy, P., Csont, T. (2012)<br />
Preconditioning protects the heart in a prolonged uremic<br />
condition. Am J Physiol Heart Circ Physiol 303: H1229-<br />
1236.<br />
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