SzSA YearBook 2016/17

SZENT-GYÖRGYI JUNIOR MENTORS
ANIKÓ KELLER-PINTÉR
Faculty of Medicine,
Department of Biochemistry,
University of Szeged
Address: Dom tér 9, H-6720 Szeged, Hungary
E: keller.aniko@med.u-szeged.hu
T: +36 62/545-096
RESEARCH AREA
Skeletal muscle is capable of exceptional regeneration following
injury. During the regeneration process, the quiescent
satellite stem cells are activated and form myoblasts
that will subsequently proliferate, differentiate, and then
fuse into multinucleated myotubes. The analysis of signalling
events of muscle regeneration and differentiation has
an important role in developmental biology; and it helps
to reveal the pathomechanisms and therapeutic possibilities
of muscle diseases. Furthermore, it can contribute to
enhance the muscle regeneration following sport injuries.
Skeletal muscle is a highly dynamic tissue; it can change in
size in response to physiological effects, or due to diseases
(e.g. chronic cardiac disease, chronic kidney diseases, or
cancer). Our other research projects focus on the analysis of
the molecular mechanisms influencing muscle adaptation,
regulation of muscle size and metabolism.
TECHNIQUES AVAILABLE IN THE LAB
Mammalian tissue culture techniques, in vivo animal models,
immunohistochemistry, immuno cyto chemistry, fluorescent
microscopy, image analysis, flow cytometry, cell
cycle analysis, cell proliferation assays, spectro photometry
(measurement of enzyme activities, metabolites), PCR, coimmuno
precipitation, GTP-ase activity assays, Western
blot.
SELECTED PUBLICATIONS
Kocsis, T., Trencsenyi, G., Szabo, K., Baán, J.A., Müller, G.,
Mendler, L., Garai, I., Reinauer, H., Deak, F., Dux, L., Keller-
Pintér, A. (2017) Myostatin propeptide mutation of the
hypermuscular Compact mice decreases the formation of
myostatin and improves insulin sensitivity. Am J Physiol
Endocrinol Metab 312: E150-E160.
Kocsis, T., Baán, J., Müller, G., Mendler, L., Dux, L., Keller-
Pintér, A. (2014) Skeletal muscle cellularity and glycogen
distribution in the hypermuscular Compact mice. Eur J
Histochem 58: 169-75.
Deák, F., Mátés, L., Korpos, É., Zvara, Á., Szénási, T., Kiricsi,
M., Mendler, L., Keller-Pinter, A., Ózsvári, B., Juhász, H.,
Sorokin, L., Dux, L., Mermod, N., Puskás, L.G., Kiss, I. (2014)
Extracellular matrilin-2 deposition controls the myogenic
program timing during muscle regeneration. J Cell Sci 127:
3240-56.
Baán, J.A., Kocsis, T., Keller-Pintér, A., Müller, G., Zádor,
E., Dux, L., Mendler, L. (2013) The Compact mutation of
myostatin causes a glycolytic shift in the phenotype of fast
skeletal muscles. J Histochem Cytochem 60: 889-900.
Keller-Pinter, A., Bottka, S., Timar, J., Kulka, J., Katona, R.,
Dux, L., Deak, F., Szilak, L. (2010) Syndecan-4 promotes
cytokinesis in a phosphorylation-dependent manner. Cell
Mol Life Sci 67: 1881–94.
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