SzSA YearBook 2016/17
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SZENT-GYÖRGYI JUNIOR MENTORS<br />
GYÖNGYI ILONA CINEGE<br />
Immunology Unit,<br />
Institute of Genetics,<br />
Biological Research Center of the<br />
Hungarian Academy of Sciences<br />
Address: Temesvári krt. 62., H-6726 Szeged, Hungary<br />
E: cinege.gyongyi@mta.brc.hu<br />
T: +36 62/599-600/462<br />
RESEARCH AREA<br />
Analysis of the Nimrod gene cluster in the model organism,<br />
Drosophila melanogaster. The cluster carries genes which<br />
encode proteins having role in the innate immune responses,<br />
as bacterial binding, phagocytosis, moreover composition<br />
of the first barrier, the cuticle. Furthermore, in the species<br />
of the ananassae subgroup following parasitoid wasp<br />
infection, multinucleated giant hemocytes (MGH) are synthesized,<br />
which kill with high efficiency the parasitoid larvae<br />
by encapsulation. We analyze the proteins expressed in the<br />
MGH, to better understand the effective killing procedure.<br />
We hope that our studies will serve as a granuloma model.<br />
TECHNIQUES AVAILABLE IN THE LAB<br />
DNA preparation, construction of plasmids, generation of<br />
transgenic fly stocks, indirect immuno fluorescence, western<br />
blot, immunoprecipitation, immuno histo-chemistry,<br />
preparation of fluorophore labeled bacteria, phagocytosis,<br />
RNA isolation, RT-PCR, development of monoclonal antibodies.<br />
SELECTED PUBLICATIONS<br />
Kari, B., Csordás, G., Honti, V., Cinege, G., Williams, M.J., Andó,<br />
I., Kurucz, É. (<strong>2016</strong>) The raspberry gene is involved in the<br />
regulation of the cellular immune response in drosophila<br />
melanogaster. PLoS One 11: e0150910.<br />
Márkus, R., Lerner, Z., Honti, V., Csordás, G., Zsámboki, J.,<br />
Cinege, G., Párducz, Á., Lukacsovich, T., Kurucz, É., Andó, I.<br />
(2015) Multinucleated giant hemocytes are effector cells in<br />
cell-mediated immune responses of drosophila. J Innate<br />
Immun 7: 340-53.<br />
Honti, V., Cinege, G., Csordás, G., Kurucz, É., Zsámboki, J.,<br />
Evans, C.J., Banerjee, U., Andó, I. (2013) Variation of NimC1<br />
expression in Drosophila stocks and transgenic strains. FLY<br />
7: 263-266.<br />
Cinege, G., Louis, S., Hänsch, R., Schnitzler, J.P. (2009)<br />
Regulation of isoprene synthase promoter by environmental<br />
and internal factors. Plant Mol Biol 69: 593-604.<br />
Cinege, G., Kereszt, A., Kertész, S., Balogh, G., Dusha I. (2003)<br />
The roles of the different regions of the CycH protein in<br />
c-type cytochrome biogenesis in Sinorhizobium meliloti.<br />
Mol Genet Genomics 271: <strong>17</strong>1-<strong>17</strong>9.<br />
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