SZENT-GYÖRGYI JUNIOR MENTORS ”Science is built on the premise that Nature answers intelligent questions intelligently; so if no answer exists, there must be something wrong with the question.” Albert Szent-Györgyi Szent-Györgyi Mentors have the opportunity to appoint a young talented researcher working in his/her laboratory who becomes the Szent-Györgyi Junior Mentor of the Szent- Györgyi Student and takes part in the Student’s education actively. Their main tasks are • taking active part in the Student’s education • taking part in the Meeting of Nobel Laureates and Talented Students organized twice a year The work of the 42 mentors is assisted by the 16 Szent-Györgyi Junior Mentors who are all scientists of the University of Szeged or the Hungarian Academy of Sciences Biological Research Center.
SZENT-GYÖRGYI JUNIOR MENTORS GYÖNGYI ILONA CINEGE Immunology Unit, Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences Address: Temesvári krt. 62., H-6726 Szeged, Hungary E: cinege.gyongyi@mta.brc.hu T: +36 62/599-600/462 RESEARCH AREA Analysis of the Nimrod gene cluster in the model organism, Drosophila melanogaster. The cluster carries genes which encode proteins having role in the innate immune responses, as bacterial binding, phagocytosis, moreover composition of the first barrier, the cuticle. Furthermore, in the species of the ananassae subgroup following parasitoid wasp infection, multinucleated giant hemocytes (MGH) are synthesized, which kill with high efficiency the parasitoid larvae by encapsulation. We analyze the proteins expressed in the MGH, to better understand the effective killing procedure. We hope that our studies will serve as a granuloma model. TECHNIQUES AVAILABLE IN THE LAB DNA preparation, construction of plasmids, generation of transgenic fly stocks, indirect immuno fluorescence, western blot, immunoprecipitation, immuno histo-chemistry, preparation of fluorophore labeled bacteria, phagocytosis, RNA isolation, RT-PCR, development of monoclonal antibodies. SELECTED PUBLICATIONS Kari, B., Csordás, G., Honti, V., Cinege, G., Williams, M.J., Andó, I., Kurucz, É. (<strong>2016</strong>) The raspberry gene is involved in the regulation of the cellular immune response in drosophila melanogaster. PLoS One 11: e0150910. Márkus, R., Lerner, Z., Honti, V., Csordás, G., Zsámboki, J., Cinege, G., Párducz, Á., Lukacsovich, T., Kurucz, É., Andó, I. (2015) Multinucleated giant hemocytes are effector cells in cell-mediated immune responses of drosophila. J Innate Immun 7: 340-53. Honti, V., Cinege, G., Csordás, G., Kurucz, É., Zsámboki, J., Evans, C.J., Banerjee, U., Andó, I. (2013) Variation of NimC1 expression in Drosophila stocks and transgenic strains. FLY 7: 263-266. Cinege, G., Louis, S., Hänsch, R., Schnitzler, J.P. (2009) Regulation of isoprene synthase promoter by environmental and internal factors. Plant Mol Biol 69: 593-604. Cinege, G., Kereszt, A., Kertész, S., Balogh, G., Dusha I. (2003) The roles of the different regions of the CycH protein in c-type cytochrome biogenesis in Sinorhizobium meliloti. Mol Genet Genomics 271: <strong>17</strong>1-<strong>17</strong>9. 79