SzSA YearBook 2016/17

SZENT-GYÖRGYI MENTORS
JÓZSEF MIHÁLY
Developmental Genetics Unit,
Institute of Genetics,
Biological Research Center of the
Hungarian Academy of Sciences
Address: Temesvári krt. 62., H-6726 Szeged, Hungary
E: mihaly.jozsef@brc.mta.hu
T: +36 62/599-687
RESEARCH AREA
The highly dynamic actin cytoskeleton is one of the structurally
and functionally most important cellular constituent.
The actin cytoskeleton is involved in such fundamental
cell biological processes as the maintenance of cell shape,
cell division, intracellular transport and motility. Beyond
that, the actin cytoskeleton is known to play a central role
in the growth and proper navigation of neuronal axons and
dendrites that are necessary to the formation of a functional
nervous system. Our major scientific interest is to gain
a better understanding of the molecular mechanisms of
axonal growth and guidance by uncovering the role of the
growth cone actin cytoskeleton regulatory proteins.
Considering that certain developmental disorders, accidental
injuries and neuro degenerative diseases often result in
severe axonal growth defects or axonal injuries, our studies
are of potential biomedical relevance as they may help to
develop more efficient neuronal regeneration methods.
TECHNIQUES AVAILABLE IN THE LAB
Classical and molecular Drosophila genetics, molecular
biology, cell biology, cytoskeleton analysis, immuno histochemistry,
the basic methods of biochemistry, fluorescent
and confocal microscopy, behavioral tests, live imaging,
digital image analysis.
SELECTED PUBLICATIONS
Gombos, R., Migh, E., Antal, O., Mukherjee, A., Jenny, A.,
Mihály, J. (2015) The Formin DAAM Functions as Molecular
Effector of the Planar Cell Polarity. Pathway during Axonal
Development in Drosophila. J Neurosci 35: 10154-67.
Nelson, KS., Khan, Z., Molnár, I., Mihály, J., Kaschube, M.,
Beitel, GJ. (2012) Drosophila Src regulates anisotropic apical
surface growth to control epithelial tube size. Nat Cell Biol
14: 518-525.
Matusek, T., Gombos, R., Szécsényi, A., Sánchez-Soriano, N.,
Czibula, A., Pataki, C., Gedai, A., Prokop, A., Raskó, I., Mihály,
J. (2008). Formin proteins of the DAAM subfamily play a role
during axon growth. J. Neurosci 28: 13310-13319.
Boutros, M., Mihaly, J., Bouwmeester, T., Mlodzik, M. (2000)
Signaling specificity by Frizzled receptors in Drosophila. Science
288: 1825-1828.
Hogga, I., Mihaly, J., Barges, S., Karch, F. (2001) Replacement
of Fab-7 by the gypsy or scs Insulator Disrupts Long-Distance
Regulatory Interactions in the Abd-B Gene of the Bithorax
Complex. Mol Cell 8: 1145-1151.
Mihaly, J., Mishra, R.K., Karch, F. (1998) A conserved sequence
motif in Polycomb-response elements. Mol Cell 1:
1065-1066.
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