SzSA YearBook 2016/17
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SZENT-GYÖRGYI MENTORS<br />
ESZTER FARKAS<br />
Department of Medical Physics and Informatics,<br />
Faculty of Medicine<br />
University of Szeged<br />
Address: Korányi fasor 9., H-6720 Szeged, Hungary<br />
E: farkas.eszter.1@med.u-szeged.hu<br />
T: +36 62/545-829<br />
RESEARCH AREA<br />
Constant, undisturbed blood supply is critical for the optimal<br />
function of the brain, the organ that regulates our body.<br />
The brain accounts for only 2% of the entire body weight,<br />
yet it receives 15% of the cardiac output and consumes 20%<br />
of available oxygen. Accordingly, any disruption or limitation<br />
of cerebral blood supply has major consequences on<br />
the integrity of the nervous tissue. Our research activities<br />
focus on various aspects of the pathophysiology of cerebrovascular<br />
diseases in experimental models.<br />
Ischemic injury to the brain favors the occurrence of spreading<br />
depolarization. Spreading depolarization is a self-propagating,<br />
transient disruption of cellular ionic homeostasis<br />
in the cerebral gray matter, which is potentially harmful<br />
to the nervous tissue. We have developed a sophisticated,<br />
live, multi-modal imaging technology, which enables us<br />
to study the evolution of spreading depolarization under<br />
experimental conditions. Our current goal is to determine<br />
how the typical features of ischemia-induced spreading depolarization<br />
are altered in old age. This is a highly relevant<br />
question, taken that cerebrovascular diseases predominantly<br />
occur in the aging population.<br />
TECHNIQUES AVAILABLE IN THE LAB<br />
Application of the Biopac© system for data acquisition and<br />
analysis, basic experimental surgical techniques, electrophysiology<br />
(DC potential and EEG recording, measurement<br />
of pH and extracellular potassium concentration in<br />
the nervous tissue), experimental micro surgery, image analysis,<br />
in vitro brain slice preparation, intrinsic optical signal<br />
analysis, laser Doppler flowmetry, laser-speckle contrast<br />
imaging of local cerebral blood flow, pharmacology, statistical<br />
methods, voltage-sensitive and pH-sensitive dye imaging<br />
of cellular trans-membrane potential.<br />
SELECTED PUBLICATIONS<br />
Hertelendy, P., Menyhárt, Á., Makra, P., Süle, Z., Kiss, T., Tóth,<br />
G., Ivánkovits-Kiss, O., Bari, F., Farkas, E. (20<strong>17</strong>) Advancing<br />
age and ischemia elevate the electric threshold to elicit<br />
spreading depolarization in the cerebral cortex of young<br />
adult rats. J Cereb Blood Flow Metab 37: <strong>17</strong>63-<strong>17</strong>75<br />
Varga, D.P., Puskás, T., Menyhárt, Á., Hertelendy, P., Zölei-<br />
Szénási, D., Tóth, R., Ivánkovits-Kiss, O., Bari, F., Farkas, E.<br />
(<strong>2016</strong>) Contribution of prostanoid signaling to the evolution<br />
of spreading depolarization and the associated cerebral<br />
blood flow response. Sci Rep 6: 31402.<br />
Menyhárt, Á., Makra, P., Szepes, B.É., M. Tóth, O., Hertelendy,<br />
P., Bari, F., Farkas, E. (2015) High incidence of adverse<br />
cerebral blood flow responses to spreading depolarization<br />
in the aged ischemic rat brain. Neurobio Aging 36: 3269-<br />
3277.<br />
Bere, Z., Obrenovitch, T.P., Kozák, G., Bari, F., Farkas, E. (2014)<br />
Imaging reveals the focal area of spreading depolarizations<br />
and a variety of hemodynamic responses in a rat microembolic<br />
stroke model. J Cereb Blood Flow Metab 34: 1695-<br />
705.<br />
Farkas, E., Pratt, R., Sengpiel, F., Obrenovitch, T.P. (2008)<br />
Direct, live imaging of cortical spreading depression and<br />
anoxic depolarisation using a fluorescent, voltage-sensitive<br />
dye. J Cereb Blood Flow Metab 28: 251-262.<br />
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