SzSA YearBook 2016/17

SZENT-GYÖRGYI MENTORS
IMRE MIKLÓS BOROS
Institute of Biochemistry, Biological Research Center of
Hungarian Academy of Sciences
Department of Biochemistry and Molecular Biology,
University of Szeged
Address: Közép fasor 52., H-6726 Szeged, Hungary
E: borosi@bio.u-szeged.hu
T: +36 62/544-686
RESEARCH AREA
Technical development during the last decade resulted
in the arrival of a post-genomic area of modern biology.
Thanks to the rapid advance in nucleic acid sequencing and
related technologies the scientific focus related to structure
and function of individual genes has shifted to studies
concerning organization and interactions of complex gene
networks and the whole genome. The laws of epigenetics,
which govern inheritance not fixed in the DNA sequence,
are being recognized nowadays. There are realistic hopes
that the new data on functioning of the genome will improve
our life directly by providing grounds for life style recommendations
and personalized medical treatments, just
to mention a few aspects.
We study gene regulation in different models with the aim
of understanding the role of proteins involved in the packaging
of DNA into chromosomes. The action of these proteins
determines whether a particular gene can manifest its
action or not. Consequently, by changing the activity of
these chromatin modifier proteins, specific gene functions
can be altered intentionally.
TECHNIQUES AVAILABLE IN THE LAB
The techniques we use for studying gene regulation are
among the most advanced ones available in the field. These
include techniques of gene engineering, culturing of different
cell types and measuring gene activity by various means.
Ongoing development further supports our work by
applying the most advanced next-generation sequencing
in our studies.
SELECTED PUBLICATIONS
Borsos, B.N., Huliák I., Majoros, H., Ujfaludi, Z., Gyenis,
Á., Pukler, P., Boros, I.M., Pankotai, T. (2017) Human p53
interacts with elongating RNAPII complex and is required
for the relese of actinomycin D induced transcription
blockade. Sci Rep 7: 40960.
Vedelek, B., Blastyak, A., Boros, I.M. (2015) Cross-Species
Interaction between Rapidly Evolving Telomere-Specific
Drosophila Proteins. PLOS One 10: e0142771.
Borsos, B.N., Pankotai, T., Kovacs, D., Popescu, C., Pahi, Z.,
Boros, IM. (2015) Acetylations of Ftz-F1 and histone H4K5
are required for the fine-tuning of ecdysone biosynthesis
during Drosophila metamorphosis. Dev Biol 404: 80-87.
Villanyi, Z., Ribaud, V., Kassem, S., Panasenko, O.O., Pahi, Z.,
Gupta, I., Steinmetz, L., Boros, I., Collart, M.A. (2014) The
not5 subunit of the ccr4-not complex connects transcription
and translation. PLOS Genet 10: e1004569.
Sike, A., Nagy, E., Vedelek, B., Pusztai, D., Szerémy, P., Venetianer,
A., Boros, I.M. (2014) mRNA Levels of Related Abcb
Genes Change Opposite to Each Other upon Histone Deacetylase
Inhibition in Drug-Resistant Rat Hepatoma Cells.
PLOS One 9: e84915.
Gyenis, A., Umlauf, D., Ujfaludi, Z., Boros, I.M., Tora, L. (2014)
UVB Induces a Genome-Wide Acting Negative Regulatory
Mechanism That Operates at the Level of Transcription
Initiation in Human Cells. PLOS Genet 10: e1004483.
Boros, I.M. (2012) Histone modification in Drosophila. Brief
Funct Genomics 11: 319-331.
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