SzSA YearBook 2016/17

SZENT-GYÖRGYI STUDENTS
MÁRTON SZENTIRMAI
Szeged Scientists Academy, 4 th year
University of Szeged,
Faculty of Medicine, 4 th year
E: marci0507ibo@gmail.com
T: +36 70/628-0919
DATE OF BIRTH:
1993
SZENT-GYÖRGYI PUPIL:
no
SZENT-GYÖRGYI MENTOR:
Dr. László Vécsei
JUNIOR MENTOR:
Dr. Dénes Zádori
SPECIALTY:
neurology
SECONDARY SCHOOL:
Radnóti Miklós Experimental
Grammar School, Szeged
NAME OF TEACHER:
Sándor Bán
LANGUAGES:
English/advanced
IMPORTANCE, AIMS AND POSSIBLE OUTCOME OF RESEARCH
I perform my current researches at the Neurology Department of the University
of Szeged. Our main focus is on the molecular pathology of different neurodegenerative
disorders. We examine progression of symptoms causing central
nervous system malfunctions in rat and mouse models and we search for possible
therapeutic solutions. Currently, we are measuring the alterations of concetrations
of molecules synthetised in the kynurenin pathway – especially the
neuroprotective kynurenic acid - of the tryptophan metabolism in the brain in
the azide model of rats which is a widely accepted model for Alzheimer’s disease.
In a paralell study, we measure tocopherol (vitamin E) concentrations in serum
and brain samples of mice applying high performance liquid cromatographic
(HPLC) method. Our goal is to validate a roboust method which we can use with
high confidence for our future measurements. Our results could help to understand
more profoundly the progression of particular neurodegenerative disorders
and the effect of some potentially therapeutic drugs.
AIMS DURING HIS CAREER
1. Intense understanding of neurological disorders and investigate neurology.
2. Acquirement of different measurement methods during laboratory work and
the generation of useful, publishable results in the field of neurology.
PUBLICATIONS
Veres, G., Fejes-Szabó, A., Zádori, D., Nagy-Grócz, G., László, AM., Bajtai, A., Mándity,
I., Szentirmai, M., Bohár, Z., Laborc, K., Szatmári, I., Fülöp, F., Vécsei, L., Párdutz,
Á. (2017) A comparative assessment of two kynurenic acid analogs in the
formalin model of trigeminal activation: a behavioral, immunohistochemical and
pharmacokinetic study. J Neural Transm (Vienna) 124: 99-112.
Veres, G., Molnár, M., Zádori, D., Szentirmai, M., Szalárdy, L., Török, R., Fazekas, E.,
Ilisz, I., Vécsei, L., Klivényi, P. (2015) Central nervous system-specific alterations in
the tryptophan metabolism in the 3-nitropropionic acid model of Huntington’s
disease. Pharmacol Biochem Behav 132: 115-124.
Fejes-Szabó, A., Bohár, Z., Vámos, E., Nagy-Grócz, G., Tar, L., Veres, G., Zádori, D.,
Szentirmai, M., Tajti, J., Szatmári, I., Fülöp, F., Toldi, J., Párdutz, Á., Vécsei, L. (2014)
Pre-treatment with new kynurenic acid amide dose-dependently prevents the
nitroglycerine-induced neuronal activation and sensitization in cervical part of
trigemino-cervical complex. J Neural Transm (Vienna) 121: 725-38.
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