SzSA YearBook 2016/17
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SZENT-GYÖRGYI STUDENTS<br />
ANNA NÁSZAI<br />
Szeged Scientists Academy, 3 rd year<br />
University of Szeged,<br />
Faculty of Medicine, 3 rd year<br />
E: naszai.anna@gmail.com<br />
T: +36 30/434-6054<br />
DATE OF BIRTH:<br />
1996<br />
SZENT-GYÖRGYI PUPIL:<br />
no<br />
SZENT-GYÖRGYI MENTOR:<br />
Dr. Mihály Boros<br />
JUNIOR MENTOR:<br />
Dr. László Juhász<br />
SPECIALTY:<br />
biochemistry, physiology,<br />
pathophysiology<br />
SECONDARY SCHOOL:<br />
Radnóti Miklós Experimental<br />
Grammar School, Szeged<br />
NAME OF TEACHER:<br />
Sándor Bán<br />
LANGUAGES:<br />
English/advanced<br />
IMPORTANCE, AIMS AND POSSIBLE OUTCOME OF RESEARCH<br />
My research project is focused on the in vitro effects of methane on xanthine<br />
oxidoreductase (XOR) enzyme and peroxynitrite (PN). XOR is the main source<br />
of reactive oxygen species (ROS) in ischaemia/reperfusion (IR), while in hypoxic<br />
circumstances it can play a role nitric oxide (NO) production due to its nitrite and<br />
nitrate reductase activity. NO and superoxide can form PN which causes lipid<br />
peroxidation and protein nitration. It has been shown that exogenic methane<br />
decreases the oxidative and nitrosative stress. Our aim was to find the mechanisms<br />
though which methane can influence inflammatory processes. Our hypotheses<br />
on one hand were that methane due to its protein conformation modifying<br />
activity can influence the enzyme activity of XOR, and on the other hand it can<br />
decrease nitrosative stress by reacting with PN. In our present studies we use<br />
flourometry for measuring the kinetic activity of XOR, chemilouminometry for<br />
measuring the amount of ROS produced by XOR, photometry for measuring the<br />
changes in nitrate/nitrite levels and enzyme-linked immunosorbent assay (ELI-<br />
SA) for measuring the amount of PN. In the future we would like to use gas chromatography-mass<br />
spectrometry (GC-MS) and NO trapping methods to precise<br />
the exact reaction between methane and PN.<br />
AIMS DURING HER CAREER<br />
I hope my research career will lead to a PhD degree and I do hope that I can witness<br />
that methane is used in clinics as a bioactive gas in decreasing IR injuries.<br />
HONORS AND PRIZES<br />
• 2013 - European Union Science Olympiad (EUSO) - gold medal<br />
• 2014 - OKTV Biology, II category, 19 th place<br />
• <strong>2016</strong> - Joint Program for European Medical Studies (JPEMS) scholarship<br />
PUBLICATIONS<br />
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112
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