SzSA YearBook 2016/17
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SZENT-GYÖRGYI STUDENTS<br />
DÓRA HANTOSI<br />
Szeged Scientists Academy, 3 rd year<br />
University of Szeged,<br />
Faculty of Medicine, 3 rd year<br />
E: dora.hantosi@gmail.com<br />
T: +36 70/668-2484<br />
DATE OF BIRTH:<br />
1995<br />
SZENT-GYÖRGYI PUPIL:<br />
yes<br />
SZENT-GYÖRGYI MENTOR:<br />
Dr. Mária Deli<br />
SPECIALTY:<br />
molecular neurobiology,<br />
biological barriers<br />
SECONDARY SCHOOL:<br />
Radnóti Miklós Experimental<br />
Grammar School, Szeged<br />
NAME OF TEACHER:<br />
Viktória Gál<br />
LANGUAGES:<br />
English/advanced<br />
IMPORTANCE, AIMS AND POSSIBLE OUTCOME OF RESEARCH<br />
In the therapy of neurological diseases the efficient transport of targeted drug<br />
delivery across the blood-brain barrier is a crucial question. Due to the prensence<br />
of the active efflux pumps of brain endothelial cells and tight junctions the transport<br />
of potencial drug candidates are usually low. As a solution to this problem<br />
vesicular and solid nanoparticles serve as promising candidates targeting the<br />
physiological transport pathways of the blood-brain barrier. The aim of our experiments<br />
was to measure the toxicity, uptake and transport rate of these particles<br />
on brain endothelial cells. We tested nano-sized, biocompatible and Evans-blue<br />
filled vesicles and solid nanoparticles on brain endothelial cell cultures during<br />
our work.<br />
AIMS DURING HER CAREER<br />
Participating in oncological clinical and research work: I would like to work in a<br />
field which is relevant to my current research and also where I will have the opportunity<br />
to work in patient-care and laboratory work as well. I am also deeply<br />
interested in oncology itself, so I really believe that this is the field that I could<br />
reach my goals.<br />
HONORS AND PRIZES<br />
• University of Szeged, Faculty of Medicine TDK conference; spring <strong>2016</strong> – 2 nd<br />
place<br />
• JPEMS scholarship<br />
• JPEMS symposium – 1 st place<br />
PUBLICATIONS<br />
Poster:<br />
Mészáros, M., Kiss, L., Hantosi, D., Bozsó, Z., Fülöp, L., Szalontai, B., Kóta, Z., Sipos,<br />
P., Szabó-Révész, P., Deli, M.A., Veszelka, S. Targeted nanoparticle delivery across<br />
brain endothelial cells using nutrient transporter ligands.<br />
(7th Szeged International Workshop on Advances in Nanoscience,<br />
The 19th International Symposium on Signal Transduction at the Blood-Brain Barriers)<br />
Articles:<br />
Veszelka, S., Bocsik, A., Walter, F.R., Hantosi, D., Deli, M.A. (2015) Blood-brain barrier<br />
co-culture models to study nanoparticle penetration: focus on co-culture systems.<br />
Acta Biol Szeged 59: 157-168.<br />
101
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