Translational Research - Université de Genève
Translational Research - Université de Genève
Translational Research - Université de Genève
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Vaccinology<br />
Claire-Anne Siegrist<br />
Departments of Pathology and Immunology<br />
Department of Pediatrics<br />
WHO Collaborative Center for Vaccine Immunology<br />
Claire-Anne Siegrist graduated in 1983. She trained in paediatrics, infectious diseases and<br />
immunology prior to <strong>de</strong>dicating her professional life to all aspects of vaccinology. Associate<br />
Professor of Vaccinology (2000) and full Professor of Paediatrics (2006), she is Presi<strong>de</strong>nt of the<br />
Swiss National Advisory Committee on Immunization (2004), member of the UK National<br />
Committee (2008) and of the WHO Strategic Advisory Group of Experts on Immunization<br />
(2010). She leads the InfoVac expert network (www.infovac.ch), has <strong>de</strong>veloped vaccinology<br />
clinical <strong>de</strong>cision support software for health care professionals (www.viavac.ch), and is the<br />
foun<strong>de</strong>r of the Swiss Electronic Vaccination Record (www.myvaccines.ch)..<br />
Vaccine immunology from early life to vaccine safety<br />
Our research focusses on i) neonatal immunology in or<strong>de</strong>r to un<strong>de</strong>rstand the postnatal<br />
<strong>de</strong>velopment process of the immune system and how it is regulated to control early life<br />
immune responses to foreign antigens; ii) vaccine immunology through which we study the<br />
mo<strong>de</strong> of action of current and novel vaccines to i<strong>de</strong>ntify strategies capable of strengthening<br />
immune competence, especially in the very young and iii) clinical vaccinology to un<strong>de</strong>rstand<br />
the <strong>de</strong>terminants of vaccine responses in patients with varying levels of immune competence<br />
because of age, un<strong>de</strong>rlying disease or immunosuppression, and thus i<strong>de</strong>ntify optimal<br />
strategies.<br />
66 <strong>Université</strong> <strong>de</strong> <strong>Genève</strong> • Faculté <strong>de</strong> mé<strong>de</strong>cine<br />
Siegrist CA, van Del<strong>de</strong>n C, Bel M, Combescure C, Delhumeau C, Cavassini M, Clerc O, Meier S,<br />
Hadaya K, Soccal PM, Yerly S, Kaiser L, Hirschel B and A. Calmy (2012) Higher memory<br />
responses in HIV-infected and kidney transplanted patients than in healthy subjects<br />
following priming with the pan<strong>de</strong>mic vaccine. Plos One 7:e40428<br />
Kamath AT, Mastelic B, Christensen D, Rochat AF, Agger EM, Pinschewer DD, An<strong>de</strong>rsen P,<br />
Lambert PH and Siegrist CA (2012) Synchronization of DC activation and antigen exposure<br />
is required for the induction of Th1/Th17 responses. J Immunol. 188:4828-37<br />
Belnoue E, Tougne C, Rochat AF, Lambert PH, Pinschewer DD and Siegrist CA (2012) Homing and<br />
adhesion patterns <strong>de</strong>termine the cellular composition of the bone marrow plasma cell<br />
niche. J Immunol. 188:1283-91.<br />
Gabay C, Bel M, Combescure C, Ribi C, Meier S, Posfay-Barbe K, Grillet S, Seebach JD, Kaiser L,<br />
Wun<strong>de</strong>rli W, Guerne PA and Siegrist CA (2011) Impact of synthetic and biological disease<br />
modifying antirheumatic drugs on antibody responses to the ASO3-adjuvanted pan<strong>de</strong>mic<br />
influenza vaccine. Arthritis & Rheumatism 63:1486-96.<br />
Kamath AT, Rochat AF, Christensen D, Agger EM, An<strong>de</strong>rsen P, Lambert PH, Siegrist CA. A<br />
Liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional<br />
T cells through the exquisite targeting of <strong>de</strong>ndritic cells. PLoS One 4:e5771<br />
Kamath AT, Rochat AF, Valenti MP, Agger EM, Lingnau K, An<strong>de</strong>rsen P, Lambert PH, Siegrist CA<br />
(2008) Adult-like anti-mycobacterial T cell and in vivo <strong>de</strong>ndritic cell responses following<br />
neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant. PLoS ONE 3:e3683.<br />
Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schnei<strong>de</strong>r P, Huard B, Lambert<br />
PH, Siegrist CA (2008) APRIL is critical for plasmablast survival in the bone marrow and<br />
poorly expressed by early life bone marrow stromal cells. Blood 111:2755-64.<br />
Contact: Claire-Anne.Siegrist@unige.ch<br />
Vaccinology<br />
<strong>Université</strong> <strong>de</strong> <strong>Genève</strong> • Faculté <strong>de</strong> mé<strong>de</strong>cine<br />
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