Translational Research - Université de Genève
Translational Research - Université de Genève
Translational Research - Université de Genève
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Host Response<br />
Jérôme Pugin<br />
Department of Anaesthesiology, Pharmacology and Intensive Care<br />
Department of Microbiology and Molecular Medicine<br />
Jérôme Pugin obtained his MD <strong>de</strong>gree in 1984 in Geneva, and later specialised in both Internal<br />
and Intensive Care medicine. He shares his time between clinical work as a Deputy Head<br />
Physician of the Intensive Care Division at Geneva University Hospitals, and research in the<br />
Department of Microbiology and Molecular Medicine at the Faculty of Medicine of the<br />
University of Geneva. He spent three years between 1991 and 1994 in the Department of<br />
Immunology of the Scripps <strong>Research</strong> Institute in La Jolla, USA. Jérôme Pugin was appointed<br />
Associate Professor in 2007 and full Professor in 2012 at the Faculty of Medicine of Geneva.<br />
Since 2011 he has been Vice-Dean of the Faculty.<br />
Recognition of bacteria by innate immunity receptors<br />
Our research interests have focused over the last 20 years on the molecular and cellular<br />
pathogenesis of sepsis. In particular, we have worked on soluble proteins involved in the innate<br />
recognition of bacteria such as soluble CD14 and MD-2, as well as in the Toll-like receptors<br />
activated by Gram-negative and Gram-positive bacteria. Another area of study is the molecular<br />
pathogenesis and cell signaling of ventilator-induced lung injury, and lung inflammation in<br />
the context of acute respiratory distress syndrome. We have also i<strong>de</strong>ntified and tested<br />
biomarkers in the field of clinical sepsis.<br />
62 <strong>Université</strong> <strong>de</strong> <strong>Genève</strong> • Faculté <strong>de</strong> mé<strong>de</strong>cine<br />
Dunn-Siegrist I, Tissières P, Drifte G, Bauer J, Moutel S, Pugin J (2012) Toll-like Receptor Activation<br />
of Human Cells by Synthetic Triacylated Lipid A-like Molecules. J Biol Chem. 287: 16121-31<br />
Tissières P, Ochoda A, Dunn-Siegrist I, Drifte G, Morales M, Pfister R, Berner M, Pugin J (2012)<br />
Innate immune <strong>de</strong>ficiency of extremely premature neonates can be reversed by interferon-γ.<br />
PLoS One 7: e32863<br />
Tissières P, Araud T, Ochoda A, Drifte G, Dunn-Siegrist I, Pugin J (2009) The expression of the<br />
acute phase MD-2 gene <strong>de</strong>pends on the cooperation between PU.1 and C/EBP ß. J. Biol.<br />
Chem. 284: 26261-72<br />
Tissières P, Dunn-Siegrist I, Comte R, Nobre V, Pugin J (2008) Soluble MD-2 is an acute phase<br />
protein and an opsonin for Gram-negative bacteria. Blood 111: 2122-31<br />
Pugin J, Dunn-Siegrist I, Dufour J, Tissières P, Charles PE, Comte R (2008) Cyclic stretch of human<br />
lung cells induces an acidification and promotes bacterial growth. Am. J. Respir. Cell Mol.<br />
Biol. 38:362-70<br />
Elson G, Dunn-Siegrist I, Daubeuf B, Pugin J (2007) Contribution of Toll-like receptors to the<br />
innate immune response to Gram-negative and Gram-positive bacteria. Blood 109:1574-8<br />
Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I (2004) Soluble MD-<br />
2 activity in plasma from patients with severe sepsis and septic shock. Blood 104: 4071-4079<br />
Contact: Jerome.Pugin@unige.ch<br />
LPS induced TLR4 clustering<br />
Host Response<br />
<strong>Université</strong> <strong>de</strong> <strong>Genève</strong> • Faculté <strong>de</strong> mé<strong>de</strong>cine<br />
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