Translational Research - Université de Genève

Virology
Francesco Negro
Department of Internal Medicine
Department of Pathology and Immunology
Francesco Negro obtained his Medical Degree in 1982 at the University of Turin, Italy. He was
postdoctoral Fellow in Georgetown, University School of Medicine, Rockville, Maryland, USA
from 1986 to 1989, and guest researcher at the Laboratory of Infectious Diseases at the National
Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA in 1989. After having
spent some time back in Turin, he joined the HUG in 1994. He was appointed Associate
Professor in 2006.
Pathogenesis of chronic hepatitis C
Our laboratory studies the pathogenesis of chronic hepatitis C, including both hepatic and
extrahepatic manifestations, with particular regard to: HCV-induced fatty liver; HCV-induced
insulin resistance; interactions between HCV and the metabolic syndrome;
factors/mechanisms of liver disease progression and resistance to interferon alpha-based
antiviral therapy (particularly host genetic and metabolic factors). This research is carried out
through the following approaches: in vitro, using (i) different expression models of single HCV
proteins (including lentivectors), (ii) subgenomic-length or full-length (infectious) HCV replicon
systems, and (iii) co-cultures of HCV-expressing hepatoma cells with other cell types of major
relevance in the pathogenesis of the metabolic syndrome as well as in vivo, using human
tissues (liver and peripheral blood mononuclear cells), taken in the setting of various
observational and interventional clinical trials
42 Université de Genève • Faculté de médecine
Bochud PY, Bibert S, Kutalik Z, Patin E, Guergnon J, Nalpas B, Goossens N, Kuske L, Müllhaupt B,
Gerlach T, Heim M, Moradpour D, Cerny A, Malinverni R, Regenass S, Dollenmaier G, Hirsch
H, Martinetti G, Gorgiewski M, Bourlière M, Poynard T, Theodorou I, Abel L, Pol S, Dufour JF,
Negro F (2012) IL28B alleles associated with poor HCV clearance are protective against liver
necroinflammatory activity and fibrosis progression in patients infected with non-1 HCV
genotypes. Hepatology 55:384-394
Clément S, Peyrou M, Sanchez-Pareja A, Bourgoin L, Ramadori P, Suter DM, Vinciguerra M,
Guilloux K, Pascarella S, Rubbia-Brandt L, Negro F, Foti M (2011) Downregulation of PTEN
and IRS1 by HCV 3a core protein triggers steatosis in hepatocytes. Hepatology 54:38-49
Bochud PY, Cai T, Overbeck K, Bochud M, Rickenbach M, Dufour JF, Muellhaupt B, Borovicka J,
Heim M, Moradpour D, Cerny A, Malinverni R, Francioli P, Negro F (2009) Genotype 3 is
associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol 51:655-666
Clement S, Juge-Aubry C, Conzelmann S, Pazienza V, Pittet-Cuenod B, Meier C, Negro F (2008)
Monocyte chemoattractant protein-1 secreted by adipose tissue induce lipid accumulation
in hepatocytes. Hepatology 48:799-807
Leandro G, Mangia A, Hui J, Fabris P, Rubbia-Brandt L, Colloredo G, Adinolfi LE, Asselah T, Jonsson
JR, Smedile A, Terrault N, Pazienza V, De Lalla F, Giostra E, Sonzogni A, Ruggiero G, Marcellin
P, Powell EE, George J, Negro F (2006) The relationship between hepatic steatosis,
inflammation and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data.
Gastroenterology 130: 1636-1642
Contact: Francesco.Negro@unige.ch
Virology
Université de Genève • Faculté de médecine
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