EULAR Highlights 2017
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Enhancing knowledge of the clinical<br />
importance of cytokine signalling<br />
The Cytokine Signalling Forum<br />
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<strong>EULAR</strong> <strong>2017</strong><br />
Conference <strong>Highlights</strong><br />
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Chairman’s Welcome<br />
Dear CSF Member,<br />
Thank you for your continued support of the Cytokine Signalling Forum. We are now in our fourth year, and continue to strive to bring you the most<br />
up-to-date and interesting data in cytokine signalling. To that end, I am delighted to share with you our pick of the <strong>EULAR</strong> highlights for <strong>2017</strong>.<br />
We have identified the most interesting and impactful abstracts being presented at this year’s meeting on both cytokine signalling and IL-6.<br />
I have also selected my ‘Chairman’s picks’: those abstracts that I feel are the most significant at this year’s congress.<br />
Cytokine Signalling<br />
Again, this year there is an interesting range of both basic and clinical science. There are several baricitinib posters covering durability and<br />
maintenance of efficacy [FRI0096], switching to monotherapy [SAT0058], and dose reduction [SAT0072]. The possibility of an anti-inflammatory<br />
biomarker profile in patients treated with filgotinib monotherapy is examined [THU0182], and the results of the DARWIN-3 open label extension study<br />
up to 144 weeks are presented in Thursday’s poster session and tour [THU0173].<br />
Tofacitinib posters in RA concentrate on long-term safety and efficacy over eight years [THU0197] as well as an examination of cardiovascular risk<br />
factors [SAT0686], and safety and efficacy in patients with an inadequate response to conventional synthetic or biologic DMARDs [THU0185].<br />
Real-world tofacitinib drug-retention data are also shared as a poster from the Swiss SCQM registry [THU0174]; and real-world tofacitinib<br />
monotherapy data from the US CORRONA registry as an oral presentation [OP0022]. Three further oral presentations on Thursday and Friday will<br />
share exciting new data from the Phase 3 tofacitinib studies in psoriatic arthritis [OP0202; OP0216] as well as long-term effectiveness of live zoster<br />
vaccine in patients with RA, subsequently treated with tofacitinib [OP0230].<br />
IL-6<br />
Several abstracts showcase key data from the clinical programmes of sarilumab, sirukumab and tocilizumab.<br />
There are three key presentations on sarilumab, including patient-reported (PROs) from two Phase 3 studies in RA [FRI0240], and efficacy and<br />
patient-reported benefits of sarilumab monotherapy versus adalimumab monotherapy in the MONARCH study [SAT0202; OP0102].<br />
Sirukimab posters focus on Phase 3 data in RA, with efficacy and safety from the SIRROUND-T study [FRI0214], analyses of health-related quality<br />
of life and work productivity from SIRROUND-D and -T, respectively [FRI0246; FRI0251], and an integrated safety analysis of the SIRROUND<br />
programme [SAT0194].<br />
Tocilizumab oral presentations examine tapering and dose reduction strategies [OP0104] as well as the long-term safety profile seen in clinical trials<br />
and post-marketing populations [OP0105]. Tocilizumab posters look at real-world data, with clinical remission in the TOSPACE trial [SAT0183], and a<br />
pooled analysis of Phase 4 data across 22 countries [SAT0199].<br />
The following pages provide an overview of these topics and highlight my ‘Chairman’s picks’. Once again, thank you for your support and<br />
enjoy <strong>EULAR</strong> <strong>2017</strong>!<br />
Yours,<br />
Prof. Iain McInnes
Key Presentations – Cytokine Signalling<br />
Wednesday, June 14, <strong>2017</strong><br />
ORAL PRESENTATIONS<br />
Still breaking news on TNF inhibitors in<br />
Rheumatoid Arthritis<br />
Hall 8 – 17:00-18:30<br />
OP0022<br />
<br />
TNFi and Tofacitinib Monotherapy and Comparative Effectiveness in<br />
Clinical Practice: Results from CORRONA Registry<br />
Thursday, June 15, <strong>2017</strong><br />
ORAL PRESENTATIONS<br />
Advances in RA and SpA pathophysiology<br />
N111/N112 – 10:15-11:45<br />
OP0161<br />
Thursday, June 15, <strong>2017</strong><br />
POSTERS<br />
THU0078<br />
THU0081<br />
THU0088<br />
THU0114<br />
THU0148<br />
THU0173<br />
<br />
THU0174<br />
THU0175<br />
The JAK1 Selective Inhibitor Filgotinib Regulates Both Enthesis and<br />
Colon Inflammation in a Mouse Model of Psoriatic Arthritis<br />
PsA: an integrated perspective<br />
Hall 8 – 15:30-17:00<br />
OP0202<br />
<br />
Efficacy and Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in<br />
Patients With Active Psoriatic Arthritis and an Inadequate Response to<br />
Tumour Necrosis Factor Inhibitors: Opal Beyond, A Randomised,<br />
Double-Blind, Placebo-Controlled, Phase 3 Trial<br />
Concomitant Use of Conventional Synthetic DMARDs and Response<br />
to Baricitinib<br />
Differences in Patient-Reported Outcomes Between Baricitinib and<br />
Comparators Among Patients With Rheumatoid Arthritis who Achieved<br />
Low Disease Activity or Remission<br />
Structural Damage Progression in Patients Treated With Methotrexate,<br />
Baricitinib Monotherapy or Baricitinib + Methotrexate Based on Their<br />
Level of Clinical Response in the Phase 3 RA-BEGIN Study<br />
Effects of Smoking on Baricitinib Efficacy in Patients With Rheumatoid<br />
Arthritis: Pooled Analysis From Two Phase 3 Clinical Trials<br />
Increase of Night QT-Interval Duration in Rheumatoid Arthritis Patients<br />
Treated With Tofacitinib During 12-Month Follow-Up<br />
Long Term Safety and Efficacy of Filgotinib in a Phase 2b Open Label<br />
Extension Study in Patients With Rheumatoid Arthritis: Results up to 144<br />
Weeks<br />
Drug Retention of Tofacitinib Versus Biologic Antirheumatic Agents in<br />
Rheumatoid Arthritis: Observational Data from the Swiss SCQM Registry<br />
Inflammation Detected With Modern Sensitive MRI Analysis Demonstrates<br />
That Therapeutic Response as Early as One Month Predicts 12-Month<br />
Radiographic Progression: Data From a Study Using Tofacitinib and<br />
Methotrexate in Methotrexate-Naïve Patients With Early RA<br />
THU0177<br />
THU0182<br />
<br />
THU0185<br />
<br />
THU0186<br />
THU0188<br />
THU0189<br />
THU0191<br />
THU0193<br />
THU0195<br />
THU0196<br />
THU0197<br />
<br />
THU0199<br />
THU0205<br />
THU0206<br />
THU0210<br />
THU0211<br />
THU0213<br />
THU0215<br />
THU0352<br />
ABT-494 Pharmacokinetics Following Administration of the Once-Daily<br />
Extended-Release Tablet Formulation Being Utilized in the Ongoing<br />
Rheumatoid Arthritis Phase 3 Trials<br />
Monotherapy with the JAK1-Selective Inhibitor Filgotinib Displays an<br />
Anti-Inflammatory Biomarker Profile in Rheumatoid Arthritis Patients<br />
Comparison of Tofacitinib Safety and Efficacy in Rheumatoid Arthritis<br />
Patients With Inadequate Response to Conventional Synthetic DMARDs,<br />
or to One or More Biological DMARDs<br />
Magnitude and Duration of Early Response With Tofacitinib: Post-Hoc<br />
Analysis of Two Phase 3, Placebo-Controlled Studies<br />
Efficacy and Safety of Tofacitinib in Patients With Rheumatoid Arthritis<br />
Who Did Not Respond to Synthetic and Biological DMARDs in<br />
Clinical Practice<br />
Safety of Four Treatment Regimens in Early Rheumatoid Arthritis<br />
Effects of Tofacitinib, an Oral Janus Kinase Inhibitor, on Patient-Reported<br />
Outcomes in Japanese Patients With Rheumatoid Arthritis<br />
Reestablishment of Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor,<br />
in Rheumatoid Arthritis Patients After Temporary Discontinuation<br />
Consistent Efficacy and Safety of Tofacitinib in Rheumatoid Arthritis<br />
Patients With Inadequate Response or Intolerance to Non-MTX<br />
csDMARDs<br />
Systematic Review and Meta-Analysis of Malignancies, Excluding Non-<br />
Melanoma Skin Cancer, in Patients With Rheumatoid Arthritis Treated<br />
With Tofacitinib or Biologic Disease-Modifying Antirheumatic Drugs<br />
Tofacitinib, an Oral Janus Kinase Inhibitor, in The Treatment of<br />
Rheumatoid Arthritis: Safety and Efficacy in Open-Label, Long-Term<br />
Extension Studies Over 8 Years<br />
Tofacitinib Improves Left Ventricular Mass and Cardiac Output in<br />
Patients With Rheumatoid Arthritis<br />
Effects of the JAK1-Selective Inhibitor Filgotinib on Multibiomarker<br />
Disease Activity Scores in Patients With Active Rheumatoid Arthritis and<br />
an Inadequate Response to Methotrexate<br />
The JAK1-Selective Inhibitor Filgotinib Reduces Multiple Markers of<br />
Inflammation Linked to Various Pathologic Cell Types and Processes in<br />
Rheumatoid Arthritis Patients<br />
Changes in Hemoglobin Levels Upon Treatment With ABT-494, A<br />
Selective JAK-1 Inhibitor, and Relation to Baseline Levels of<br />
C-Reactive Protein<br />
Meta-Analysis of Serious Infections With Baricitinib, Tofacitinib and<br />
Biologic DMARDs in Rheumatoid Arthritis<br />
Comparative Efficacy and Safety of Baricitinib 2 Mg and 4 Mg in<br />
Patients With Active Rheumatoid Arthritis: A Bayesian Network Meta-<br />
Analysis of Randomized Controlled Trials<br />
Effects of Tofacitinib on Patient-Reported Outcomes in a Phase 3 Study<br />
of Chinese Patients With Active Rheumatoid Arthritis and an Inadequate<br />
Response to DMARDs<br />
Tofacitinib Treatment is Associated With Attainment of the Minimally<br />
Important Reduction in Axial MRI Inflammation in Patients With<br />
Ankylosing Spondylitis<br />
Chairman’s picks
Friday, June 16, <strong>2017</strong><br />
ORAL PRESENTATIONS<br />
From classics to new: synthetic DMARDs in RA<br />
Hall 7A – 10:15-11:45<br />
LB0003<br />
OP0230<br />
<br />
Tofacitinib With and Without Methotrexate Versus Adalimumab With<br />
Methotrexate for the Treatment of Rheumatoid Arthritis: Results From<br />
Oral Strategy, A Phase 3b/4 Randomised Trial<br />
The Effectiveness of Zoster Vaccine in RA Patients Subsequently Treated<br />
With Tofacitinib<br />
PsA: the options grow!<br />
Hall 8 – 10:15-11:45<br />
OP0216<br />
<br />
Efficacy and Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, or<br />
Adalimumab in Patients With Active Psoriatic Arthritis and an Inadequate<br />
Response to Conventional Synthetic Disease-Modifying Antirheumatic<br />
Drugs (csDMARDs): A Randomised, Placebo-Controlled, Phase 3 Trial<br />
Friday, June 16, <strong>2017</strong><br />
POSTERS<br />
FRI0071<br />
FRI0086<br />
Tofacitinib Restores the Inhibition of Reverse Cholesterol Transport<br />
Induced by Inflammation: Understanding the Lipid Paradox Associated<br />
With Rheumatoid Arthritis<br />
Efficacy and Safety Data Based on Historical or Pre-Existing Conditions<br />
at Baseline for Patients With Active Rheumatoid Arthritis Who Were<br />
Treated With Baricitinib<br />
FRI0087 Low Rates of Radiographic Progression of Structural Joint Damage Over 2<br />
Years of Baricitinib Treatment in Patients With Rheumatoid Arthritis<br />
FRI0089 Effect of Starting Dose of Baricitinib In Achieving Sustained Low<br />
Disease Activity<br />
FRI0090 Analysis of Neutrophils, Lymphocytes, and Platelets In Pooled Phase 2<br />
and Phase 3 Studies of Baricitinib for Rheumatoid Arthritis<br />
FRI0092 Effects of Baricitinib on Haemoglobin and Related Laboratory<br />
Parameters in Rheumatoid Arthritis Patients<br />
FRI0096 Durability and Maintenance of Efficacy Following Prolonged Treatment<br />
With Baricitinib<br />
FRI0124 Temporary Interruptions of Study Drug During the Baricitinib Phase 3<br />
Rheumatoid Arthritis Program<br />
FRI0231 The First Report of Significant Increase of Body Mass Index in<br />
Rheumatoid Arthritis Patients Treated With Tofacitinib During 12-Month<br />
Follow-Up<br />
FRI0428 The JAK1-Selective Inhibitor, Filgotinib, Inhibits Inflammation Pathways<br />
Observed in an IL23-Induced Psoriatic Arthritis Mouse Model<br />
FRI0496 Comparing Tofacitinib Safety Profile in Patients With Psoriatic Arthritis in<br />
Clinical Studies With Real-World Data<br />
FRI0509 Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, Up To<br />
24 Months in Patients With Active Psoriatic Arthritis: Interim Data From<br />
Opal Balance, an Open-Label, Long-Term Extension Study<br />
Saturday, June 17, <strong>2017</strong><br />
POSTERS<br />
SAT0055<br />
SAT0058<br />
<br />
SAT0069<br />
SAT0070<br />
SAT0072<br />
<br />
SAT0149<br />
SAT0217<br />
SAT0439<br />
SAT0469<br />
SAT0686<br />
<br />
<strong>EULAR</strong> <strong>2017</strong><br />
Baricitinib Showed Rapid and Greater Reduction in Pain Compared to<br />
Adalimumab or Placebo in Patients With Rheumatoid Arthritis<br />
Effects of Baricitinib on Patients Who Stop Methotrexate Monotherapy<br />
and Switch to Baricitinib Monotherapy<br />
A Rapid3-Like Index Documents Superior Efficacy of Baricitinib to<br />
Adalimumab and Placebo, Similar To DAS28 And CDAI In The Ra-Beam<br />
Clinical Trial In Patients With Rheumatoid Arthritis<br />
Baricitinib Versus Adalimumab in Patients With Active Rheumatoid Arthritis:<br />
Analysis Of Patients Achieving a Moderate <strong>EULAR</strong> Response at Week 4<br />
Dose Reduction of Baricitinib in Patients With Rheumatoid Arthritis<br />
Achieving Sustained Disease Control: Results of a Prospective Study<br />
Comparative Effectiveness of Tofacitinib, Biologic Drugs and Traditional<br />
Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis<br />
Early Patient-Reported Outcomes and Clinical Outcomes With ABT-494<br />
in Patients With Active Rheumatoid Arthritis Who Are Inadequate<br />
Responders to Methotrexate or Tumor Necrosis Factor Inhibitors: Post-<br />
Hoc Analysis Of Phase 2 Randomized Controlled Trials<br />
Integrated Safety Summary of Tofacitinib in Psoriatic Arthritis Clinical Studies<br />
Integrated Efficacy Analysis of Tofacitinib, an Oral Janus Kinase Inhibitor,<br />
in Patients With Active Psoriatic Arthritis<br />
Major Adverse Cardiovascular Events: Risk Factors in Patients With RA<br />
Treated With Tofacitinib<br />
ABSTRACT ONLY<br />
AB0098 Effects of Tofacitinib in Early Arthritis Bone Loss<br />
AB0235 Effect of Baseline Disease Activity on Achieving Sustained Low Disease<br />
Activity in Baricitinib Phase 3 Studies<br />
AB0261 Clinical and Structural Responses of Patients With Active Rheumatoid<br />
Arthritis (RA) Using Step-Up Dosages of Tofacitinib In A Treat To<br />
Target Approach<br />
AB0281 Characterization of Changes In Lymphocyte Subsets in Baricitinib-<br />
Treated Patients With Early, DMARD Naïve, Rheumatoid Arthritis In A<br />
Phase 3 Study<br />
AB0403 Adherence and Access to Biological Therapy and Tofacitinib in a Cohort<br />
of Colombian Patients With Rheumatological Diseases<br />
AB0407 Comparative Effectiveness of Tocilizumab (TCZ) Monotherapy With<br />
Tumor Necrosis Factor Inhibitors (TNFi) in Combination With Varying<br />
Doses of Methotrexate (MTX) in Patients With Rheumatoid Arthritis<br />
AB0419 Real World Use of Tofacitinib in Rheumatoid Arthritis: Data From<br />
Latin America<br />
AB0431 Post-Marketing Surveillance of Tofacitinib in Japanese Patients With<br />
Rheumatoid Arthritis: An Interim Report Of Safety Data<br />
AB0432 ABT-494 Has No Effect on the QT Interval at the Doses Being Evaluated<br />
in Rheumatoid Arthritis Phase 3 Trials<br />
AB0434 Tofacitinib in Rheumatoid Arthritis: Real Life Experience<br />
AB0436 Comparison of Tofacitinib Efficacy in Patients With Moderate vs Severe<br />
Rheumatoid Arthritis: Pooled Analysis of Phase 3 Studies<br />
AB0794 Effect of Tofacitinib on Patient-Reported Outcomes in Patients With<br />
Active Psoriatic Arthritis: Results from Two Phase 3 Studies<br />
Chairman’s picks
Key Presentations – IL-6<br />
Thursday, June 15, <strong>2017</strong><br />
ORAL PRESENTATIONS<br />
Progress in biological treatment of RA<br />
Hall 8 – 10:15-11:45<br />
OP0102<br />
<br />
OP0103<br />
OP0104<br />
<br />
OP0105<br />
<br />
Patient Reported Benefits of Sarilumab Monotherapy Versus Adalimumab<br />
Monotherapy in Adult Patients with Active Rheumatoid Arthritis<br />
The Effect of Sirukumab Plus Methotrexate on Circulating Biomarkers<br />
of Joint Destruction in Moderate to Severe Rheumatoid Arthritis Patients<br />
from the SIRROUND-D Phase 3 Study<br />
Tocilizumab: Dose Reduction or Interval Spacing – Which Proves a<br />
Better Tapering Strategy for Rheumatoid Arthritis in Clinical Remission?<br />
Long-Term Safety of Tocilizumab from Large Clinical Trial and<br />
Postmarketing Populations<br />
Heterogeneity in JIA<br />
N105/N106 – 13:30-15:00<br />
OP0197<br />
Evaluation of a Dosing Regimen for Tocilizumab in Patients Younger Than<br />
Two Years of Age With Systemic Juvenile Idiopathic Arthritis<br />
Thursday, June 15, <strong>2017</strong><br />
POSTERS<br />
THU0055<br />
THU0130<br />
THU0134<br />
THU0503<br />
THU0511<br />
THU0526<br />
THU0567<br />
Low Molecular Weight BAFF Signaling Inhibitors Ameliorate IL-6, IL-10<br />
and IgG Production In Vitro and In Vivo Models of Autoimmune Diseases<br />
Improvement in Measures Of Depressed Mood And Anhedonia in Two<br />
Randomized, Placebo-Controlled Phase III Studies Of Sirukumab, A<br />
Human Anti-Interleukin-6 Antibody, in Patients With Rheumatoid Arthritis<br />
Interstitial Lung Disease and Rheumatoid Arthritis. Multicenter Study<br />
With Tocilizumab<br />
Identification of Optimal Subcutaneous (SC) Doses of Tocilizumab in<br />
Children With Polyarticular-Course Juvenile Idiopathic Arthritis (PCJIA)<br />
Tocilizumab is a Promising Treatment Option for Therapy Resistent<br />
Juvenile Localised Scleroderma Patients<br />
Short and Long-Term Follow-Up of Tocilizumab for Severe Juvenile<br />
Idiopathic Arthritis-Associated Uveitis<br />
Rapid Improvement with Tocilizumab in Refractory and Severe Uveitic<br />
Cystoid Macular Edema<br />
THU0577 Tocilizumab Monotherapy for Adult Onset Still’s Disease ~ Results of 52-<br />
Week Treatment of a Prospective, Single-Center, Single-Arm, Open Trial<br />
Friday, June 16, <strong>2017</strong><br />
POSTERS<br />
FRI0213<br />
FRI0214<br />
<br />
FRI0215<br />
FRI0225<br />
FRI0227<br />
FRI0228<br />
FRI0233<br />
FRI0239<br />
FRI0240<br />
<br />
FRI0242<br />
FRI0243<br />
FRI0246<br />
<br />
FRI0247<br />
FRI0248<br />
FRI0251<br />
<br />
Comparative Effectiveness of Abatacept, Rituximab, Tocilizumab and<br />
Anti-TNF Biological DMARDs In RA: Results from the Nationwide<br />
Swedish Register<br />
Long-Term Efficacy and Safety of Sirukumab in Patients with Active<br />
Rheumatoid Arthritis Despite Anti-Tumor Necrosis Factor Therapy:<br />
Results of the Randomized, Phase 3 SIRROUND-T Study<br />
Comparative Efficacy and Retention Rate of Tocilizumab and TNF Inhibitors<br />
used in Combination With Methotrexate as First-Line Biologic Therapy in<br />
Rheumatoid Arthritis: Data from a Multicentre Observational Registry<br />
Anemia is a Better Predictor for Radiographic Damage in Rheumatoid<br />
Arthritis Than DAS28 When Determined Before Start of Tocilizumab-<br />
Treatment – A Secondary Analysis From The ACT-Ray Trial<br />
Sarilumab Significantly Suppresses Circulating Biomarkers of Bone<br />
Resorption and Cardiovascular Risk Compared With Adalimumab:<br />
Biomarker Analysis from the Phase 3 Monarch Study<br />
UGT1A1 Genetic Variants Are Associated With Increases In Bilirubin<br />
Levels In Rheumatoid Arthritis Patients Treated With Sarilumab<br />
The Retention Rates of Abatacept in Elderly RA Patients (65 Years and<br />
Above) Who Cannot Be Treated With Methotrexate: Comparison With<br />
Etanercept And Tocilizumab; A Single-Center, Retrospective, Case-<br />
Control Study<br />
Results of a Phase 2b Study of Vobarilizumab, an Anti-Interleukin-6<br />
Receptor Nanobody, as Monotherapy In Patients With Moderate To<br />
Severe Rheumatoid Arthritis<br />
Rheumatoid Arthritis (RA) Impact Following Treatment With Sarilumab:<br />
Patient Reported Outcomes Using The Raid Scale From Two<br />
Randomized Phase III Trials<br />
Association Between Clinical and Radiographic Responses, and Physical<br />
Function in a Phase 3 Study of Sarilumab Plus Methotrexate in Patients<br />
with Active, Moderate-To-Severe Rheumatoid Arthritis<br />
Sirukumab Treatment Reduces Levels of Iron-Regulatory Proteins and<br />
Ameliorates Inflammation-Associated Anemia in Rheumatoid Arthritis<br />
Patients<br />
Improvements in Health-Related Quality of Life With Sirukumab are<br />
Statistically Significant, Clinically Meaningful, and Meet or Exceed<br />
Normative Values in Rheumatoid Arthritis Patients with Inadequate<br />
Response to Disease-Modifying Antirheumatic Drugs: Post Hoc Analyses<br />
of a Phase 3 Trial<br />
Median Time to Low Disease Activity is Shorter in Tocilizumab<br />
Combination Therapy With csDMARDs as Compared to Monotherapy in<br />
Patients with Active Rheumatoid Arthritis and Inadequate Responses to<br />
csDMARDs and/or TNF Inhibitors: Subanalysis of the Swiss and Austrian<br />
Patients from The ACT-Sure Study<br />
Incidence Of Melanoma In Patients With Rheumatoid Arthritis Treated<br />
With Tocilizumab<br />
Sirukumab, an Anti-Il-6 Cytokine Monoclonal Antibody, Leads to<br />
Improvements in Work Productivity and General Health Status in<br />
Patients with Active Rheumatoid Arthritis Refractory to Anti-TNF<br />
Therapy: Results from the Phase 3 SIRROUND-T Study<br />
Chairman’s picks
FRI0252<br />
FRI0253<br />
FRI0254<br />
FRI0313<br />
FRI0321<br />
FRI0336<br />
FRI0673<br />
Saturday June 17, 2016<br />
POSTERS<br />
SAT0026<br />
SAT0083<br />
SAT0170<br />
SAT0181<br />
SAT0182<br />
SAT0183<br />
<br />
SAT0184<br />
SAT0189<br />
SAT0192<br />
SAT0193<br />
SAT0194<br />
<br />
Summary of Neutropenia in Patients with Rheumatoid Arthritis Treated<br />
with Sirukumab in the SIRROUND Phase 3 Clinical Trials<br />
Patient-Reported Outcomes in Patients with Rheumatoid Arthritis<br />
Treated with Subcutaneous Tocilizumab Compared with Placebo or<br />
Intravenous Tocilizumab in Combination with csDMARDs<br />
Efficacy of Tocilizumab for Suppressing Radiographic Progression of<br />
Cervical Lesions in Patients with Rheumatoid Arthritis Comparison<br />
with Methotrexate Treatment; Two Years of Follow-Up ~A Multicenter<br />
Registry Study ~<br />
The Efficacy and Safety of Tocilizumab Therapy in Patients With<br />
Polymyalgia Rheumatica who were Resistant or Intolerant to<br />
Glucocorticoids and Additional Methotrexate<br />
Circulating Il-6 and Other Metabolic Biomarkers Comparing Effects<br />
of Modified-Release Prednisone (MR) and Immediate-Release<br />
Prednisolone (IR) in new GCA<br />
Efficacy of Tocilizumab in 31 Patients with Giant Cell Arteritis<br />
Clinical Remission in Tocilizumab-Using Rheumatoid Arthritis Patients<br />
can be Overestimated: A Cross Sectional Study Using Ultrasound<br />
Sonography<br />
Signalling Through Insulin-Like Growth Factor 1 Receptor Contributes<br />
to IL-6 Production and Supports T Cell Dependent Inflammation in<br />
Rheumatoid Arthritis<br />
Tocilizumab Induced Clinical Remission in Rheumatoid Arthritis had<br />
More Residual Doppler Signals in Comparison With Other Biologics<br />
B-Cell Phenotype and IGD-CD27- Memory B Cells are Affected by TNF-<br />
Inhibitors and Tocilizumab Treatment in Rheumatoid Arthritis<br />
Low Dose Interleukin-2 Combined with Tocilizumab Selectively<br />
Increases Regulatory T Cells Helping Refractory Rheumatoid Arthritis<br />
Patients Achieve Remission More Rapidly<br />
Sirukumab Leads to Significant and Clinically Meaningful Improvements<br />
in Health-Related Quality of Life That Meet or Exceed Normative Values<br />
in Patients With Rheumatoid Arthritis Refractory to TNF Inhibitors in Post<br />
Hoc Analyses of a Phase 3 Trial<br />
Clinical Remission in Subjects With Rheumatoid Arthritis Treated With<br />
Subcutaneous Tocilizumab as Monotherapy or in Combination With<br />
Methotrexate Or Other Synthetic Dmards: A Real-World Clinical Trial<br />
(TOSPACE)<br />
Therapeutic Drug Monitoring on Rheumatoid Arthritis Patients With<br />
Reduced Doses of Intravenous Tocilizumab<br />
Factors Influencing the Prescription of Tocilizumab Alone or in<br />
Combination With DMARDs in Rheumatoid Arthritis Patients in a Real<br />
Life Setting. Pooled Analysis of 3 Observational Studies<br />
Sarilumab Suppresses Thrombosis-Related Gene Expression in<br />
Circulating Blood Cells in MTX-IR and TNF-IR Patients With Active<br />
Rheumatoid Arthritis<br />
RA Patients With Inflammatory Anemia Benefit From Increased<br />
Hemoglobin and Decreased Fatigue Under Tocilizumab Therapy<br />
Sirukumab Integrated Safety in Rheumatoid Arthritis Patients: Analysis<br />
of the SIRROUND Phase 3 Data<br />
SAT0198 Tocilizumab for the Management of Rheumatoid Arthritis:<br />
Discontinuation Due to Inefficacy and Toxicity – Experience from a Large<br />
Teaching Hospital<br />
SAT0199 Subcutaneous Tocilizumab Monotherapy or Combined With a csDMARD<br />
in Patients With Rheumatoid Arthritis: Tozura, a Pooled Analysis of Phase<br />
IV Studies In 22 Countries<br />
SAT0202 Efficacy and Safety of Sarilumab Monotherapy Versus Adalimumab<br />
Monotherapy in Patients With Active Rheumatoid Arthritis in the Phase 3<br />
Monarch Study, Including Subpopulations<br />
SAT0203 Significance of Extension of Tocilizumab Infusion Intervals From 4<br />
Weeks to 6 Weeks in RA Patients Who Had Shown Good Response to 4<br />
Week Intervals<br />
SAT0206 Retention of Tocilizumab as Monotherapy Versus TNF Inhibitors With<br />
Conventional Synthetic DMARDs in Rheumatoid Arthritis Patients With<br />
Inadequate Response to TNF Inhibitors: A Study From The TOCERRA<br />
Collaboration<br />
SAT0209 Observational Study on the Effects of IL-6 Inhibitor Therapy on Myostatin<br />
in Patients With Rheumatoid Arthritis<br />
SAT0212 Sarilumab Dose Reduction in an Open-Label Extension Study in RA<br />
Patients With Inadequate Response to TNF Inhibitors<br />
SAT0214 An Analysis of Increasing Spacing Time for the Intravenous<br />
Administration of Tocilizumab in Patients With Rheumatoid Arthritis<br />
SAT0218 Effect of Tocilizumab in DMARD-Naïve Early Rheumatoid Arthritis Patients<br />
on Health-Related Quality Of Life: Results of the U-ACT-Early Trial<br />
SAT0524 Utility of Tocilizumab in Clinical Manifestations of Erosive Osteoarthrosis<br />
of Hands<br />
Regional Hospital ISSTE Puebla, México<br />
Chairman’s picks
<strong>EULAR</strong> <strong>2017</strong><br />
ABSTRACT ONLY<br />
AB0051 Interleukin-6 Blockade With Tocilizumab Decreases Metalloproteinase-9<br />
Activity in Synovial Fibroblasts Stimulated With Synovial Fluids of<br />
Patients With Rheumatoid Arthritis or Spondyloarthritis<br />
AB0238 The Influence of Fatigue in the Definition of Remission in Rheumatoid<br />
Arthritis Patients Treated With Tocilizumab<br />
AB0395 Subcutaneous Tocilizumab as Monotherapy or in Combination With a<br />
csDMARD In Patients With Rheumatoid Arthritis: 24 Weeks Results Of<br />
The French Phase IIIb Study, “Tosca”<br />
AB0396 Tocilizumab I.V. Effectiveness in RA Patients is Independent of<br />
Smoking Status<br />
AB0400 Efficacy and Safety of Intravenous and Subcutaneous Tocilizumab in a<br />
Cohort of Patients Affected by Rheumatoid Arthritis in Real-Life<br />
AB0401 The Efficent Regulation of Tocilizumab for the Expression Of CD4+/<br />
CD8+ T/CD19 + B Cells and the Immunoglobulin in Systemic Juvenile<br />
Idiopathic Arthritis<br />
AB0406 Stable Efficacy and Safety After Switching From Tocilizumab Intravenous<br />
to Subcutaneous in Rheumatoid Arthritis: Results of a Cohort of<br />
200 Patients<br />
AB0407 Comparative Effectiveness of Tocilizumab (TCZ) Monotherapy With<br />
Tumor Necrosis Factor Inhibitors (TNFi) in Combination With Varying<br />
Doses of Methotrexate (MTX) in Patients With Rheumatoid Arthritis<br />
AB0409 Corticosteroid-Sparing in Patients With Rheumatoid Arthritis on<br />
Tocilizumab: First Experience Of Bab -El- Oued Hospital<br />
AB0413 Induction and Progression of Subcutaneous Nodulosis in Rheumatoid<br />
Arthritis Patients Treated With Tocilizumab<br />
AB0416 Which Factors Predict the Responsiveness to Tocilizumab in Rheumatoid<br />
Arthritis? The Difference Between the Usage as the First Biologic and as<br />
the Second Biologic<br />
AB0952 Experience of Tocilizumab Use in Treatment of Juvenile Idiopathic<br />
Atrtritis in Chelyabinsk Regional Children Hospital<br />
AB0964 Some Pecularities of the Course of Juvenile Idiopathic Arthritis in<br />
Patients Treated With Tocilizumab<br />
AB0984 Tocilizumab Monotherapy for Polymyalgia Rheumatica ~ Results of 52-<br />
Week Treatment of a Prospective, Single-Center, Open, Single-Arm Trial
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