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Methods – Eligibility Criteria<br />
• Inclusion criteria:<br />
– Age ≥18 years<br />
– Active RA (≥6/66 swollen joints and ≥6/68 tender joints)<br />
– hsCRP above upper limit of normal (5 mg/L) or seropositive for both<br />
anti-CCP and rheumatoid factor<br />
– Study 1: Active RA despite MTX treatment 1<br />
‣ Patients were required to discontinue all other DMARDs for a<br />
pre-specified duration before baseline 1<br />
– Study 2: Active RA despite ≥1 anti-TNF treatment for ≥3 months 2<br />
‣ Patients had discontinued TNF therapy because of intolerance or toxicity<br />
‣ All biologic agents had to be washed out prior to randomisation<br />
hsCRP, high-sensitivity C-reactive peptide.<br />
1. <strong>Genovese</strong> MC, et al. Arthritis Rheum 2016;68:2857–66. 2. <strong>Kremer</strong> JM, et al. Arthritis Rheum 2016;68:2867–77.
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