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Guidelines for the Management of Occupational Exposures to HBV ...

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Human Studies <strong>of</strong> HIV PEP<br />

Efficacy<br />

• Study <strong>of</strong> converters vs nonconverters showed use <strong>of</strong><br />

zidovudine (ZDV) was associated with an 81%<br />

decrease in <strong>the</strong> risk <strong>for</strong> HIV infection<br />

– limitations include a small number <strong>of</strong> cases, and<br />

that cases and controls came from different<br />

cohorts ((Cardo Cardo et et al, al, NEJM NEJM 1997;337:1485--90.)<br />

1997;337:1485 90.)

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