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(12) PATENT APPLICATION PUBLICATION (21) Application No.6265/DELNP/2008 A<br />

(19) INDIA<br />

(22) Date <strong>of</strong> filing <strong>of</strong> Application :17/07/2008 (43) Publication Date : 24/10/2008<br />

(54) Title <strong>of</strong> the invention : MEANS AND METHODS FOR MEDIATING PROTEIN INTERFERENCE<br />

(51) International classification :A61K 38/16 (71)Name <strong>of</strong> Applicant :<br />

(31) Priority Document No :60/753,245<br />

1)VIB VZW<br />

(32) Priority Date :22/12/2005<br />

Address <strong>of</strong> Applicant :RIJVISSCHESTRAAT 120, B-9052<br />

(33) Name <strong>of</strong> priority country :U.S.A.<br />

ZWIJNAARDE, BELGIUM Belgium<br />

(86) International Application No :PCT/EP2006/070184 2)VRIJE UNIVERSITEIT BRUSSEL<br />

Filing Date<br />

:22/12/2006 (72)Name <strong>of</strong> Inventor :<br />

(87) International Publication No :WO 2007/071789 1)SCHYMKOWITZ, JOOST<br />

(61) Patent <strong>of</strong> Addition to Application<br />

Number<br />

Filing Date<br />

:NA<br />

:NA<br />

2)ROUSSEAU, FREDERIC<br />

(62) Divisional to Application Number :NA<br />

Filing Date<br />

:NA<br />

(57) Abstract :<br />

The present invention belongs to the field <strong>of</strong> functional proteomics <strong>and</strong> more <strong>part</strong>icularly to the field <strong>of</strong> protein aggregation. The<br />

invention discloses a method for interfering with the function <strong>of</strong> a target protein <strong>and</strong> uses a non-naturally, user-designed molecule,<br />

designated as interferor, that has a specificity for a target protein <strong>and</strong> which induces aggregation upon contact with said target protein.<br />

The present invention also discloses such interferor molecules <strong>and</strong> their use in therapeutic applications.<br />

No. <strong>of</strong> Pages : 64 No. <strong>of</strong> Claims : 15<br />

The Patent Office Journal 24/10/2008 25827

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