continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6307/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :18/07/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : "IMMULOMODULATORY COMPOUNDS AND TREATMENT OF DISEASES RELATED TO AN
OVERPRODUCTION OF INFLAMMATORY CYTOKINES"
(51) International classification : C07D 471/06 (71)Name of Applicant :
(31) Priority Document No :PCT/IB2006/050748 1)OM PHARMA
(32) Priority Date :09/03/2006
Address of Applicant :22, RUE DU BOIS-DU-LAN,
(33) Name of priority country :EPO
P.O.BOX 84, CH-1217 MEYRIN 2 SWITZERLAND.
(86) International Application No :PCT/IB2007/000567 Switzerland
Filing Date
:09/03/2007 (72)Name of Inventor :
(87) International Publication No :WO 2007/102081 1)BAUER JACQUES
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
2)CHIAVAROLI CARLO
3)MOUTEL STEPHANE
(62) Divisional to Application Number :NA
Filing Date
:NA
(57) Abstract :
The invention relates to the use of immunomodulatory compounds for the treatment of diseases related to to an overproduction of
inflammatory cytokines, such as diseases selected from the group consisting of asthma, atopic dermatitis, allergic rhinitis, prostatitis,
inflammatory bowel disease, diabetes, and rhumatoid arthritis, said compounds being of general formula (I), wherein : m and n,
independently from each other, are an integer ranging from 1 to 4, X and Y represent -COOH, -0-P(O)(OH)2, -O- SO2(OH), -NH2, -
OH, -CONH(CH2)ni-NH2, -CO-NH-CH(COOH)- (CH2)n1COOH, -CO-NH-CH(COOH)- (CH2)n1-NH2, -0-CO-(CH2)n1NH2,-0-
CO-(CH2)n1-CHOH-CH2OH, -0-CO-(CH2)n1-OH, -0-CO-(CH2)n1-COOH, -O- CO-(CH2)nrCHO, -0-CO-(CH2)n1-NH-CO-
(CH2)n2-COOH, R-, and R2 each designate an acyl group derived from a saturated or unsaturated, straight- or branched-chain
carboxylic acid having from 2 to 18 carbon atoms, which is unsubstituted or bears one to three substituents selected among hydroxyl,
dihydroxyphosphoryloxy, alkyl of 2 to 18 carbon atoms, alkoxy of 2 to 18 carbon atoms, acyloxy of 2 to 18 carbon atoms in the acyl
moiety, amino, acylamino.
No. of Pages : 65 No. of Claims : 13
The Patent Office Journal 24/10/2008 25782