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(12) PATENT APPLICATION PUBLICATION (21) Application No.6793/DELNP/2008 A (19) INDIA (22) Date of filing of Application :07/08/2008 (43) Publication Date : 24/10/2008 (54) Title of the invention : "PROCESS FOR THE PREPARATION OF 11BETA-HYDROXY-9BETA, 10ALPHA - STEROIDS EMPLOYING AMYCOLATORPSIS MEDITERRANEI CELLS" (51) International classification :C07J 7/00 (71)Name of Applicant : (31) Priority Document No :06100503.9 1)SOLVAY PHARMACEUTICALS GMBH (32) Priority Date :18/01/2006 Address of Applicant :HANS-BOCKLER-ALLEE 20, 30173 (33) Name of priority country :EPO HANNOVER, GERMANY. Germany (86) International Application No :PCT/EP2007/050412 (72)Name of Inventor : Filing Date :16/01/2007 1)MESSINGER, JOSEF (87) International Publication No :WO 2007/082891 2)THOLE, HEINRICH-HUBERT (61) Patent of Addition to Application Number Filing Date :NA :NA 3)RASCHE, HEINZ-HELMER 4)SCHMIDT, MICHAEL 5)HAKALA, JUHA (62) Divisional to Application Number :NA Filing Date :NA (57) Abstract : The invention relates to the use of bacterial strains of the species Amycolatopsis moditcrranci for the microbial transformation of 9 β,10α-steroids of general Formula (I) to their corresponding 11β-hydroxyl analogues, as well as to specific strains of that species. In addition, the present invention relates to the process of transforming 9 β,10α-steroids to their corresponding 11 β -hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and to the subsequent isolation of the 11 β -hydroxyl derivatives from the bacterial culture medium. The resultant 11 β -hydroxylated products are useful intermediates for the preparation of novel steroidal compounds with 9 β,10α-confirmation carrying different kind of substituents in the 11 β -position. No. of Pages : 43 No. of Claims : 18 The Patent Office Journal 24/10/2008 26234
(12) PATENT APPLICATION PUBLICATION (21) Application No.6794/DELNP/2008 A (19) INDIA (22) Date of filing of Application :07/08/2008 (43) Publication Date : 24/10/2008 (54) Title of the invention : "MODULATION OF GENE EXPRESSIONS BY DOCOSAHEXAENOIC ACID" (51) International classification :A61K 31/202 (71)Name of Applicant : (31) Priority Document No :60/777,724 1)BRISTOL-MYERS SQUIBB COMPANY (32) Priority Date :28/02/2006 Address of Applicant :LAWRENCEVILLE-PRINCETON (33) Name of priority country :U.S.A. ROAD, PRINCETON, NEW JERSEY 08543, U.S.A U.S.A. (86) International Application No :PCT/US2007/004451 2)CORNELL RESEARCH FOUNDATION, INC. Filing Date :21/02/2007 (72)Name of Inventor : (87) International Publication No :WO 2007/100566 1)ZEINA JOUNI, J.JOSHUA C. ANTHONY (61) Patent of Addition to Application Number Filing Date :NA :NA 2)STEVEN C. RUMSEY 3)DESHANIE RAI 4)THOMAS J.BRENA (62) Divisional to Application Number :NA 5)KUMAR SESHA DURGA KOTHAPALLI Filing Date :NA (57) Abstract : The present invention is directed to a novel method for modulating the expression of one or more genes in a subject by administering an amount of DHA and ARA to the subject. No. of Pages : 614 No. of Claims : 9 The Patent Office Journal 24/10/2008 26235
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