continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6793/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :07/08/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : "PROCESS FOR THE PREPARATION OF 11BETA-HYDROXY-9BETA, 10ALPHA - STEROIDS
EMPLOYING AMYCOLATORPSIS MEDITERRANEI CELLS"
(51) International classification :C07J 7/00 (71)Name of Applicant :
(31) Priority Document No :06100503.9
1)SOLVAY PHARMACEUTICALS GMBH
(32) Priority Date :18/01/2006
Address of Applicant :HANS-BOCKLER-ALLEE 20, 30173
(33) Name of priority country :EPO
HANNOVER, GERMANY. Germany
(86) International Application No :PCT/EP2007/050412 (72)Name of Inventor :
Filing Date
:16/01/2007
1)MESSINGER, JOSEF
(87) International Publication No :WO 2007/082891 2)THOLE, HEINRICH-HUBERT
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
3)RASCHE, HEINZ-HELMER
4)SCHMIDT, MICHAEL
5)HAKALA, JUHA
(62) Divisional to Application Number :NA
Filing Date
:NA
(57) Abstract :
The invention relates to the use of bacterial strains of the species Amycolatopsis moditcrranci for the microbial transformation of 9
β,10α-steroids of general Formula (I) to their corresponding 11β-hydroxyl analogues, as well as to specific strains of that species. In
addition, the present invention relates to the process of transforming 9 β,10α-steroids to their corresponding 11 β -hydroxyl derivatives
using bacterials strains of the species Amycolatopsis mediterranei, and to the subsequent isolation of the 11 β -hydroxyl derivatives
from the bacterial culture medium. The resultant 11 β -hydroxylated products are useful intermediates for the preparation of novel
steroidal compounds with 9 β,10α-confirmation carrying different kind of substituents in the 11 β -position.
No. of Pages : 43 No. of Claims : 18
The Patent Office Journal 24/10/2008 26234