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(12) PATENT APPLICATION PUBLICATION (21) Application No.6791/DELNP/2008 A<br />

(19) INDIA<br />

(22) Date <strong>of</strong> filing <strong>of</strong> Application :06/08/2008 (43) Publication Date : 24/10/2008<br />

(54) Title <strong>of</strong> the invention : MODIFIED MACROMOLECULE<br />

(71)Name <strong>of</strong> Applicant :<br />

1)STARPHARMA PTY.LTD.<br />

(51) International classification :A61K 31/74<br />

Address <strong>of</strong> Applicant :BAKER BUILDING,75<br />

(31) Priority Document No :2006900310<br />

COMMERCIAL ROAD, MELBOURNE, VICTORIA<br />

(32) Priority Date :20/01/2006<br />

3004,AUSTRALIA. Australia<br />

(33) Name <strong>of</strong> priority country :Australia<br />

(72)Name <strong>of</strong> Inventor :<br />

(86) International Application No :PCT/AU2006/000637<br />

1)BOYD, BENJAMIN JAMES<br />

Filing Date<br />

:15/05/2006<br />

2)KAMINSKAS,LISA MICHELLE<br />

(87) International Publication No :WO 2007/082331<br />

3)PORTER,CHRISTOPHER JOHN HAMILTON<br />

(61) Patent <strong>of</strong> Addition to Application<br />

:NA<br />

4)KARELLAS,PETER<br />

Number<br />

:NA<br />

5)KRIPPNER,GUY YEOMAN<br />

Filing Date<br />

6)KELLY, BRIAN DEVLIN<br />

(62) Divisional to Application Number :NA<br />

7)WU, ZEMIN<br />

Filing Date<br />

:NA<br />

8)RAZZINO,PASQUALE<br />

9)PALLICH, SUI<br />

(57) Abstract :<br />

The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a<br />

surface layer, at least one subsurface layer <strong>and</strong> at least two terminal groups including: a first terminal group which is a residue <strong>of</strong> a<br />

pharmaceutically active agent, a derivative there<strong>of</strong> or precursor therefor; <strong>and</strong> a second terminal group selected to modify the<br />

pharmacokinetics <strong>of</strong> the pharmaceutically active agent <strong>and</strong>/or macromolecule, wherein terminal group stoichiametry refers to the<br />

number <strong>and</strong> type <strong>of</strong> terminal groups.<br />

No. <strong>of</strong> Pages : 166 No. <strong>of</strong> Claims : 49<br />

The Patent Office Journal 24/10/2008 26232

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