continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6790/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :06/08/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : METHOD OF CREATING BIOLOGICAL AND BIOSYNTHETIC FOR IMPLANTATION
(51) International classification :A61L 27/00 (71)Name of Applicant :
(31) Priority Document No :PR2173
1)KETHARANATHAN, JUDITH MARY widow and sole
(32) Priority Date :20/12/2000 executor of the will of late KETHARANATHAN,
(33) Name of priority country :Australia
VETTIVETPILLAI
(86) International Application No :PCT/AU2001/01619 Address of Applicant :192 THE AVENUE, PARKVILLE,
Filing Date
:14/12/2001 VICTORIA 3052, AUSTRALIA Australia
(87) International Publication No :WO 2002/49687 (72)Name of Inventor :
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
1)KETHARANATHAN, JUDITH MARY
(62) Divisional to Application Number :00969/DELNP/2003
Filed on
:24/06/2003
(57) Abstract :
A method of creating an implantation material from biological and tissue engineered biosynthetic and biological tissue of autogenic,
allogenic and xenogenic origin suitable for implantation into humans or animals as surgical and vascular prostheses. The resultant
material inhibits in vivo calcification and provides a non-porous biomatrix which is impervious to angiogenesis and tissue ingrowth
and suitable for the adhesion and retention of transplanted living cells such as endothelial cells, without the need for additional
extracellular matrix protein coating. The method, which incorporates a gradual increase in glutaraldehyde concentration from 0% to
no more than 5% weight/volume in a pH which is gradually changed from acid to alkaline at room temperature, maintains the microarchitecture
and the cellular lining of the material. Additionally flexibility, compliance and haemo-compatibility along with strength
and durability can be varied according to the end use. The glutaraldehyde penetrates the material gradually and completely, cross
linking the collagenous components of the tissue.
No. of Pages : 24 No. of Claims : 36
The Patent Office Journal 24/10/2008 26231