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(12) PATENT APPLICATION PUBLICATION (21) Application No.6779/DELNP/2008 A<br />

(19) INDIA<br />

(22) Date <strong>of</strong> filing <strong>of</strong> Application :06/08/2008 (43) Publication Date : 24/10/2008<br />

(54) Title <strong>of</strong> the invention : "A NOVEL MRNA SPLICE VARIANT OF THE DOUBLECORTIN-LIKE KINASE GENE AND ITS<br />

USE IN DIAGNOSIS AND THERAPY OF CANCERS OF NEUROECTODERMAL ORIGIN"<br />

(51) International classification :C12N 15/54 (71)Name <strong>of</strong> Applicant :<br />

(31) Priority Document No :06075152.6<br />

1)PROSENSA B.V.<br />

(32) Priority Date :25/01/2006<br />

Address <strong>of</strong> Applicant :EINSTEINWEG 55, NL-2333 CC<br />

(33) Name <strong>of</strong> priority country :EPO<br />

LEIDEN, THE NETHERLANDS. Netherl<strong>and</strong>s<br />

(86) International Application No :PCT/NL2007/050025 (72)Name <strong>of</strong> Inventor :<br />

Filing Date<br />

:23/01/2007<br />

1)VREUGDENHIL, ERNO<br />

(87) International Publication No :WO 2007/086738 2)VAN KUIK-ROMEIJN, PETRA<br />

(61) Patent <strong>of</strong> Addition to Application<br />

Number<br />

Filing Date<br />

:NA<br />

:NA<br />

3)PLATENBURG, GERARD JOHANNES<br />

(62) Divisional to Application Number :NA<br />

Filing Date<br />

:NA<br />

(57) Abstract :<br />

The present invention relates to novel nucleic acid <strong>and</strong> protein molecules <strong>and</strong> their use in cancer therapy <strong>and</strong> diagnosis which is used<br />

as nucleic acid fragment <strong>of</strong> SEQ ID NO: 1 or 2, or <strong>of</strong> a variant <strong>of</strong> SEQ ID NO: 1 or 2, said nucleic acid fragment being capable <strong>of</strong><br />

causing a significant reduction <strong>of</strong> the amount <strong>of</strong> DCL-protein <strong>of</strong> SEQ ID NO: 3 or 4, for the preparation <strong>of</strong> a composition for the<br />

treatment <strong>of</strong> cancer.<br />

No. <strong>of</strong> Pages : 60 No. <strong>of</strong> Claims : 12<br />

The Patent Office Journal 24/10/2008 26207

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