continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6761/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :06/08/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : ANTIGEN-BINDING PROTEINS TARGETING S. AUREUS ORF0657N
(71)Name of Applicant :
(51) International classification :A61K 39/40
1)MERCK & CO., INC.
(31) Priority Document No :60/763,023
Address of Applicant :126 EAST LINCOLN AVENUE,
(32) Priority Date :27/01/2006
RAHWAY, NEW JERSEY 07065-0907, U.S.A. U.S.A.
(33) Name of priority country :U.S.A.
(72)Name of Inventor :
(86) International Application No :PCT/US2007/001687
1)BROWN, MARTHA, J.
Filing Date
:23/01/2007
2)ANDERSON, ANNALIESA, S.
(87) International Publication No :WO 2007/089470
3)COPE, LESLIE, D.
(61) Patent of Addition to Application
:NA
4)JANSEN, KATHRIN, UTE
Number
:NA
5)MCNEELY, TESSIE
Filing Date
6)HARVEY, BARRETT
(62) Divisional to Application Number :NA
7)DURR, ERBERHARD
Filing Date
:NA
8)ERNST, ROBIN
(57) Abstract :
The present invention features antigen binding protein that bind an ORF0657n target region (SEQ ID NO: 1). ORF0657n is an S.
aureus protein. ORF0657n target regions are provided by the mAb 1G3.BD4, mAb 2H2.BE11, mAb 13C7.BC1, and mAb 13G11.BF3
binding sites. In a lethal model challenge, mAb 2H2.BE11 and mAb 13C7.BC1 provided for increased survival against S. aureus
infection. There was also protection demonstrated in an ex vivo model with either the IgGl or the IgG2b form of mAb 2H2; and in a
passive immunization murine indwelling catheter model using mAb 2H2.BE11.
No. of Pages : 60 No. of Claims : 31
The Patent Office Journal 24/10/2008 26176