continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6625/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :30/07/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : "PRODUCTION OF A SOLUBLE NATIVE FORM OF RECOMBINANT PROTEIN BY THE SIGNAL
SEQUENCE AND SECRETIONAL ENHANCER"
(51) International classification :C12N 15/63 (71)Name of Applicant :
(31) Priority Document No :10-2006-0009418 1)REPUBLIC OF KOREA (REPUBLIC OF NATIONAL
(32) Priority Date :31/01/2006 FISHERIES RESEARCH AND DEVELOPMENT
(33) Name of priority country :Republic of Korea INSTITUTE
(86) International Application No :PCT/KR2007/000515 Address of Applicant :408-1 SIRANG-RI, GIJANG-EUP,
Filing Date
:30/01/2007 GIJANG-GUN BUSAN 619-902, REPUBLIC OF KOREA.
(87) International Publication No :WO 2007/089093 Republic of Korea
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
2)BEXCORE INC.
(72)Name of Inventor :
1)LEE SANG JUN
(62) Divisional to Application Number :NA
2)KIM YOUNG OK
Filing Date
(57) Abstract :
:NA
3)NAM BO-HYE
The present invention is drawn to a method for enhancing secretional efficiency of a heterologous protein using a secretional enhancer
consisting of a modified signal sequence which comprises the N-region of a signal sequence and/or a hydrophobic fragment of the said
signal sequence comprising the said N-region and/or the hydrophilic polypeptide. The method of the present invention can be used not
only for production of recombinant heterologous proteins by inhibiting insoluble precipitation and enhancing secretional efficiency of
the recombinant protein into the periplasm or the extracellular fluid and but also for transduction of therapeutic proteins by enhancing
membrane-permeability of the recombinant protein using a strong secretional enhancer.
No. of Pages : 102 No. of Claims : 61
The Patent Office Journal 24/10/2008 26084