continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6503/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :25/07/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : "BINDING MOLECULES"
(51) International classification :C07K 16/00 (71)Name of Applicant :
(31) Priority Document No :0601513.5
1)ERASMUS UNIVERSITY MEDICAL CENTRE
(32) Priority Date :25/01/2006 ROTTERDAM
(33) Name of priority country :U.K.
Address of Applicant :DEPARTMENT OF CELL BIOLOGY
(86) International Application No :PCT/GB2007/000258 AND GENETICS, P.O. BOX 2040, NL-3000 CA ROTTERDAM,
Filing Date
:25/01/2007 NETHERLANDS Netherlands
(87) International Publication No :WO 2007/085837 (72)Name of Inventor :
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
1)FRANKLIN GERADUS GROSVELD
2)RICHARD WILHELM JANSSENS
3)DUBRAVKA DRABEK
(62) Divisional to Application Number :NA
4)ROGER KINGDOM CRAIG
Filing Date
:NA
(57) Abstract :
The present invention relates to the manufacture of mono, di and multivalent polypeptide binding complexes, also mono, di or
multispecific polypeptide binding complexes and uses thereof. The invention also relates to the manufacture and use of a diverse
repertoire of antigen specific VH binding domains derived from phage display libraries, transgenic animals or natural sources.
Preferably the VH binding domains and the dimerisation domains comprise human sequences. The polypeptide binding complexes
comprise homo or heterodimerisation domains with four antigen binding [VH ] domains fused at the amino and carboxyl termini of
the dimerisation domains preferably using natural hinge or linker peptides. Where the polypeptide binding complexes lack CH2-CH3
effector functions they are preferably less than 120kDa in size. Routes of manufacture are described herein.
No. of Pages : 40 No. of Claims : 26
The Patent Office Journal 24/10/2008 25994