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(12) PATENT APPLICATION PUBLICATION (21) Application No.6250/DELNP/2008 A<br />

(19) INDIA<br />

(22) Date <strong>of</strong> filing <strong>of</strong> Application :17/07/2008 (43) Publication Date : 24/10/2008<br />

(54) Title <strong>of</strong> the invention : METHOD FOR PREDICTING BIOLOGICAL SYSTEMS RESPONSES<br />

(51) International classification :G01N 35/50 (71)Name <strong>of</strong> Applicant :<br />

(31) Priority Document No :60/759,476<br />

1)CELLUMEN, INC.<br />

(32) Priority Date :17/01/2006<br />

Address <strong>of</strong> Applicant :3180 WILLIAM PITT WAY,<br />

(33) Name <strong>of</strong> priority country :U.S.A.<br />

PITTSBURGH, PA 15238, (US) U.S.A.<br />

(86) International Application No :PCT/US2007/001217 (72)Name <strong>of</strong> Inventor :<br />

Filing Date<br />

:17/01/2007<br />

1)GIULIANO, KENNETH<br />

(87) International Publication No :WO 2008/018905 2)GOUGH, ALBERT<br />

(61) Patent <strong>of</strong> Addition to Application<br />

Number<br />

Filing Date<br />

:NA<br />

:NA<br />

3)JOHNSTON, PATRICIA<br />

4)TAYLOR D. LANSING<br />

(62) Divisional to Application Number :NA<br />

Filing Date<br />

:NA<br />

(57) Abstract :<br />

The inventive method employs a 'systems biology' approach to predicting biological responses resulting <strong>from</strong> exposure to the test<br />

substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects <strong>of</strong> a test<br />

substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) <strong>of</strong> response<br />

pr<strong>of</strong>iles for reference substrances .with known biological systems effects. In another embodiment, the invention provides a set <strong>of</strong><br />

protocols <strong>and</strong> s<strong>of</strong>tware tools used to carry out the pr<strong>of</strong>iling. Another embodiment <strong>of</strong> the invention is a panel <strong>of</strong> reagents <strong>and</strong> protocols<br />

required for generating response pr<strong>of</strong>iles, either to create an knowledgebase, or to use with an existing knowledgebase <strong>and</strong> informatics<br />

s<strong>of</strong>tware to pr<strong>of</strong>ile substance physiological effects. Another embodiment <strong>of</strong> the invention is a database <strong>of</strong> physiological pr<strong>of</strong>iles.<br />

No. <strong>of</strong> Pages : 54 No. <strong>of</strong> Claims : 54<br />

The Patent Office Journal 24/10/2008 25755

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