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(12) PATENT APPLICATION PUBLICATION (21) Application No.6437/DELNP/2008 A (19) INDIA (22) Date of filing of Application :23/07/2008 (43) Publication Date : 24/10/2008 (54) Title of the invention : "MICROBACTERIAL SECA2 MUTANTS" (51) International classification :C12N 1/21 (71)Name of Applicant : (31) Priority Document No :60/758,944 1)ALBERT EINSTEIN COLLEGE OF MEDICINE OF (32) Priority Date :12/01/2006 YESHIVA UNIVERSITY, (33) Name of priority country :U.S.A. Address of Applicant :1300 MORRIS PARK AVENUE, (86) International Application No :PCT/US2007/000793 BRONX, NY 10461, U.S.A. U.S.A. Filing Date :11/01/2007 2)THE UNIVERSITY OF NORTH CAROLINA AT (87) International Publication No :WO 2007/084353 CHAPEL HILL, (61) Patent of Addition to Application Number Filing Date :NA :NA (72)Name of Inventor : 1)WILLIAM R. JACOB, 2)STEVEN A. PORCELLI, (62) Divisional to Application Number :NA 3)MIRIAM BRAUNSTEIN, Filing Date :NA (57) Abstract : Provided are mycobacteria comprising (a) a mutation that is not in a SccA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants. No. of Pages : 65 No. of Claims : 36 The Patent Office Journal 24/10/2008 25976
(12) PATENT APPLICATION PUBLICATION (21) Application No.6440/DELNP/2008 A (19) INDIA (22) Date of filing of Application :23/07/2008 (43) Publication Date : 24/10/2008 (54) Title of the invention : "NOVEL RADIOLIGANDS" (51) International classification :C07D 311/24 (71)Name of Applicant : (31) Priority Document No :60/773,302 1)ASTRAZENECA AB (32) Priority Date :14/02/2006 Address of Applicant :S-151 85 SODERTALJE, SWEDEN. (33) Name of priority country :U.S.A. Sweden (86) International Application No :PCT/SE2007/000135 (72)Name of Inventor : Filing Date :14/02/2007 1)JOHN RICHARD HEYS (87) International Publication No :WO 2007/094718 2)EDWARD PIERSON (61) Patent of Addition to Application Number Filing Date :NA :NA 3)WILLIAM POTTS (62) Divisional to Application Number :NA Filing Date :NA (57) Abstract : 1 he present invention provides novel radioligands for the 5-HTiB receptor of the formula I. No. of Pages : 17 No. of Claims : 13 The Patent Office Journal 24/10/2008 25977
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