continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6437/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :23/07/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : "MICROBACTERIAL SECA2 MUTANTS"
(51) International classification :C12N 1/21 (71)Name of Applicant :
(31) Priority Document No :60/758,944
1)ALBERT EINSTEIN COLLEGE OF MEDICINE OF
(32) Priority Date :12/01/2006 YESHIVA UNIVERSITY,
(33) Name of priority country :U.S.A.
Address of Applicant :1300 MORRIS PARK AVENUE,
(86) International Application No :PCT/US2007/000793 BRONX, NY 10461, U.S.A. U.S.A.
Filing Date
:11/01/2007
2)THE UNIVERSITY OF NORTH CAROLINA AT
(87) International Publication No :WO 2007/084353 CHAPEL HILL,
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
(72)Name of Inventor :
1)WILLIAM R. JACOB,
2)STEVEN A. PORCELLI,
(62) Divisional to Application Number :NA
3)MIRIAM BRAUNSTEIN,
Filing Date
:NA
(57) Abstract :
Provided are mycobacteria comprising (a) a mutation that is not in a SccA2 gene that attenuates the virulence of the mycobacteria in a
mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a
mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or
Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of
inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants.
No. of Pages : 65 No. of Claims : 36
The Patent Office Journal 24/10/2008 25976