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(12) PATENT APPLICATION PUBLICATION (21) Application No.6449/DELNP/2008 A<br />

(19) INDIA<br />

(22) Date <strong>of</strong> filing <strong>of</strong> Application :23/07/2008 (43) Publication Date : 24/10/2008<br />

(54) Title <strong>of</strong> the invention : "TUBEROUS SCLEROSIS TREATMENT"<br />

(51) International classification :A61K 31/436 (71)Name <strong>of</strong> Applicant :<br />

(31) Priority Document No :0602123.3<br />

1)NOVARTIS AG.<br />

(32) Priority Date :02/02/2006<br />

Address <strong>of</strong> Applicant :LICHTSTRASSE 35, CH-4056 BASEL<br />

(33) Name <strong>of</strong> priority country :U.K.<br />

SWITZERLAND. Switzerl<strong>and</strong><br />

(86) International Application No :PCT/EP2007/000818 (72)Name <strong>of</strong> Inventor :<br />

Filing Date<br />

:31/01/2007<br />

1)BERG WILLIAM<br />

(87) International Publication No :WO 2007/088034 2)BENEDETTO JOHN<br />

(61) Patent <strong>of</strong> Addition to Application<br />

Number<br />

Filing Date<br />

:NA<br />

:NA<br />

3)ELMROTH INGRID<br />

4)LANE HEIDI<br />

5)LEBWOHL DAVID<br />

(62) Divisional to Application Number :NA<br />

6)SELLERS WILLIAM<br />

Filing Date<br />

(57) Abstract :<br />

:NA<br />

7)STUMM MICHAEL<br />

Rapamycin derivatives for use in the treatment <strong>of</strong> neurocutaneous disorders. A compound <strong>of</strong> formula (Formula Removed) wherein R1<br />

is CH3 or C3-6alkynyl, R2 is H, -CH2-CH2-OH or -CH2-CH2-CHC1-8)alkyl, e.g. -CH2-CH2-O-CH2-CH3, <strong>and</strong> X is = O, (H, H) or<br />

(H, OH). provided that R2 is other than H when X is =O <strong>and</strong> R1 is CH3, or the compound ABT578, the compound CCI779, the<br />

compound AP23573, or the compound TAFA-93, for use in the treatment <strong>of</strong> neurocutaneous disorders.<br />

No. <strong>of</strong> Pages : 41 No. <strong>of</strong> Claims : 15<br />

The Patent Office Journal 24/10/2008 25946

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