continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.619/DELNP/2005 A
(19) INDIA
(22) Date of filing of Application :17/02/2005 (43) Publication Date : 24/10/2008
(54) Title of the invention : A RECOMBINAT PROTEIN COMPLEX
(51) International classification :A61K 39/395 (71)Name of Applicant :
(31) Priority Document No :60/400,410
1)WYETH
(32) Priority Date :01/08/2002
Address of Applicant :FIVE GIRALDA FARMS, MADISON,
(33) Name of priority country :U.S.A.
NJ 07940 (US) U.S.A.
(86) International Application No :PCT/US2003/024340 (72)Name of Inventor :
Filing Date
:01/08/2003
1)KUAI, JUN
(87) International Publication No :WO 2004/012673 2)LIN, LIH-LING
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
3)WOOTERS, JOSEPH, L.
4)NICKBARG, ELLIOTT
(62) Divisional to Application Number :NA
Filing Date
:NA
(57) Abstract :
The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-α)
and/or tumor necrosis factor alpha receptor (TNFR). Preferably, the complexes comprise at least one polypeptide selected from the
group consisting of: NF-ĸB activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further provides assays
of identifying a compound for modulating the stability and activity of the complex. Also provided are methods of modulating
apoptosis and inflammation, as well as treating TNF-α related diseases.
No. of Pages : 45 No. of Claims : 16
The Patent Office Journal 24/10/2008 25748