continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6201/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :16/07/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : "METHOD FOR TREATING DISSEMINATED CANCER"
(51) International classification :C12N 5/06 (71)Name of Applicant :
(31) Priority Document No :60/752,844
1)SENTOCLONE AB
(32) Priority Date :21/12/2005
Address of Applicant :ALLEN 5, SE-17266 SUNDBYBERG,
(33) Name of priority country :U.S.A.
SWEDEN. Sweden
(86) International Application No :PCT/EP2006/012305 (72)Name of Inventor :
Filing Date
:20/12/2006
1)OLA WINQVIST
(87) International Publication No :WO 2007/071389 2)MAGNUS THORN
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
(62) Divisional to Application Number :NA
Filing Date
:NA
(57) Abstract :
The present invention discloses an immunotherapeutic method for treating a patient suffering from a disseminated cancer by
administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more metastasis-draining
lymph nodes (metinel nodes) draining a metastasis. The method comprises identification of one or more metinel lymph nodes in a
patient, resection of the one or more nodes and, optionally all or part of the metastases, isolation of metastasis-reactive T-lymphocytes
from said lymph nodes, in vitro expansion of said metastasis-reactive T-lymphocytes, and administration of the thus obtained Tlymphocytes
to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.
No. of Pages : 57 No. of Claims : 23
The Patent Office Journal 24/10/2008 25747