continued from part 1 - Controller General of Patents, Designs, and ...

(12) PATENT APPLICATION PUBLICATION (21) Application No.6200/DELNP/2008 A
(19) INDIA
(22) Date of filing of Application :16/07/2008 (43) Publication Date : 24/10/2008
(54) Title of the invention : "IMPROVED METHOD FOR EXPANSION OF TUMOUR -REACTIVE T-LYMPHOCYTES FOR
IMMUNOTHERAPY OF PATIENTS WITH CANCER"
(51) International classification :C12N 5/06 (71)Name of Applicant :
(31) Priority Document No :60/752, 828
1)SENTOCLONE AB
(32) Priority Date :21/12/2005
Address of Applicant :ALLEN 5, SE-17266 SUNDBYBERG,
(33) Name of priority country :U.S.A.
SWEDEN. Sweden
(86) International Application No :PCT/EP2006/012304 (72)Name of Inventor :
Filing Date
:20/12/2006
1)OLA WINQVIST
(87) International Publication No :WO 2007/071388 2)MAGNUS THORN
(61) Patent of Addition to Application
Number
Filing Date
:NA
:NA
(62) Divisional to Application Number :NA
Filing Date
:NA
(57) Abstract :
The present invention discloses an improved method for expansion and activation of tumour-reactive lymphocytes, in particular CD4+
helper and/or CD8+ T-lymphocytes, which may be used for treating and/or preventing cancer. The method provides high numbers of
tumour-reactive T-lymphocytes within a short time span and the possibility of directing development of tumour-reactive CD4+ helper
and/or CD8+ T-lymphocytes towards specific subpopulations. The method comprises a first phase of stimulating tumour-reactive
CD4+ T helper and/or CD8+ T-lymphocytes with tumour-derived antigen together with at least one substance having agonistic
activity towards the IL-2 receptor to promote survival of tumour-reactive CD4+ T helper and/or CD8+ T-lymphocytes; and a second
phase of activating and promoting growth of tumour-reactive CD4+ T helper and/or CD8+ T-lymphocytes, wherein the second phase
is initiated when the CD25 cell surface marker (or IL-2R marker) is down-regulated on CD4+ T helper and/or CD8+ T-lymphocytes.
No. of Pages : 61 No. of Claims : 21
The Patent Office Journal 24/10/2008 25746