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Randomized trial in China, 112,604 healthy adults assigned to receive<br />
3 doses of HEV recombinant vaccine against G 1 and 4 (Hecolin)<br />
Protective efficacy over a 12-month period 96% 4<br />
Efficacy 4.5 yrs after the 1 st vaccination 87% 5 1.Zhang M, et al. Vaccine 2002; 20:3285.<br />
2.Tsarev SA, et al. Proc Natl Acad Sci U S A 1994; 91:10198.<br />
3.Khuroo MS, Dar MY. Indian J Gastroenterol 1992; 11:113.<br />
4.Shrestha MP, et al. N Engl J Med 2007; 356:895<br />
5.Zhang J, et al. N Engl J Med 2015; 372:914.<br />
Prevention of HEV Transmission<br />
Advice to<br />
travelers to HEV<br />
endemic regions<br />
Recombinant<br />
vaccines 1<br />
2,3<br />
Pre- or postexposure<br />
Ig prophylaxis??
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