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Treatment of HEV: Future Therapy<br />
■ SOF inhibits HEV-G3 replication both in sub-genomic replicon systems<br />
as well as a full-length infectious clone.<br />
■ SOF+RBV results in an additive antiviral effect.<br />
■ More studies to explore antiviral potential of SOF+RBV, especially if<br />
RBV monotherapy fails.<br />
■ SOF as an add-on therapy to RBV for the treatment of chronic HEV in<br />
immunocompromised patients.<br />
Dao Thi VL, et al. Gastroenterology. 2016 Jan. 150(1):82-85.e4.<br />
Debing Y, et al. J Hepatol. 2016 Jul. 65(1):200-12
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