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Treatment of Chronic HEV<br />
■ 12-week course of RBV monotherapy (600 mg daily): 1,2<br />
-IS therapy cannot be reduced.<br />
-Persistent HEV-RNA despite a reduction in IS for 3 months. 1,2<br />
■ ??No RCT, only case series<br />
■ 59 solid-organ transplant recipients with chronic HEV-G3 received 3<br />
months of RBV monotherapy.<br />
Outcome<br />
HEV clearance 95% (n=56)<br />
SVR 78% (n=46)<br />
AEs<br />
Anemia: reduction in RBV dose (29%)<br />
EPO(54%), blood transfusion(12%) 3<br />
1.Wedemeyer H et al. Gastroenterology 2012; 142:1388.<br />
2.Kamar N. et al Clin Microbiol Rev 2014; 27:116.<br />
3.Kamar N, et al. N Engl J Med 2014; 370:1111.
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