Hepatitis E: What’s New?

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Treatment of Chronic HEV Reduction of Immunosuppressive Therapy HEV-RNA in blood and stool after 12 weeks Viral clearance in 30% in a series of 85 recipients of solid organ transplants who had chronic HEV Kamar N, ]et al. Gastroenterology 2011; 140:1481.
Treatment of Chronic HEV ■ 12-week course of RBV monotherapy (600 mg daily): 1,2 -IS therapy cannot be reduced. -Persistent HEV-RNA despite a reduction in IS for 3 months. 1,2 ■ ??No RCT, only case series ■ 59 solid-organ transplant recipients with chronic HEV-G3 received 3 months of RBV monotherapy. Outcome HEV clearance 95% (n=56) SVR 78% (n=46) AEs Anemia: reduction in RBV dose (29%) EPO(54%), blood transfusion(12%) 3 1.Wedemeyer H et al. Gastroenterology 2012; 142:1388. 2.Kamar N. et al Clin Microbiol Rev 2014; 27:116. 3.Kamar N, et al. N Engl J Med 2014; 370:1111.
Page 2 and 3: HEPATITIS E: WHAT’S NEW? Naglaa Z
Page 4 and 5: Known Facts: HEV ■ 20 million HEV
Page 6 and 7: Geographical Distribution of HEV Eg
Page 8 and 9: HEV Genotypes Four genotypes/24 sub
Page 10 and 11: Modes of HEV Transmission Fecal-ora
Page 12 and 13: Clinical Picture of HEV
Page 14 and 15: Complications of Acute HEV Acute Li
Page 16 and 17: Clinical Picture: Complications Acu
Page 18 and 19: Chronic Hepatitis E Persistently el
Page 20 and 21: Chronic Hepatitis E Other Immunosup
Page 22 and 23: Diagnostic tests for HEV IgM anti-H
Page 24 and 25: HEV Diagnosis Acute HEV Chronic HEV
Page 26 and 27: Treatment of HEV Acute HEV Signific
Page 30 and 31: Response to Antiviral Therapy Stool
Page 34 and 35: Treatment of HEV: Future Therapy
Page 36 and 37: Randomized trial in China, 112,604

Hepatitis E: What’s New?

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