Hepatitis E: What’s New?
Chronic Hepatitis E Other Immunosuppressed hosts ■ Case reports in patients with non-Hodgkin lymphoma receiving rituximab and in patients with HIV infection. 1,2 ■ Low risk of acute HEV compared with the general population. ■ Failure to clear HEV and consequently develop chronic infection. 3 1.Ollier L, et al. Ann Intern Med 2009; 150:430. 2.Dalton HR, et al. N Engl J Med 2009; 361:1025 3.Goel A, Aggarwal R. Expert Rev Gastroenterol Hepatol 2016; 10:1065.
HEV Diagnosis General approach ■ Clinical suspicion in acute or chronic hepatitis that cannot be explained by other causes, particularly in the setting of known risk factors. ■ Suspected among patients with rapidly progressive liver disease in pregnant women, patients with underlying CLD, solid organ transplant recipients, and hematologic malignancies. ■ Patients presenting with an elevation in aminotransferases & neurological manifestations. Wedemeyer H, et al.Gastroenterology 2012; 142:1388. Pawlotsky JM. Lancet 2014; 384:1729.
- Page 2 and 3: HEPATITIS E: WHAT’S NEW? Naglaa Z
- Page 4 and 5: Known Facts: HEV ■ 20 million HEV
- Page 6 and 7: Geographical Distribution of HEV Eg
- Page 8 and 9: HEV Genotypes Four genotypes/24 sub
- Page 10 and 11: Modes of HEV Transmission Fecal-ora
- Page 12 and 13: Clinical Picture of HEV
- Page 14 and 15: Complications of Acute HEV Acute Li
- Page 16 and 17: Clinical Picture: Complications Acu
- Page 18 and 19: Chronic Hepatitis E Persistently el
- Page 22 and 23: Diagnostic tests for HEV IgM anti-H
- Page 24 and 25: HEV Diagnosis Acute HEV Chronic HEV
- Page 26 and 27: Treatment of HEV Acute HEV Signific
- Page 28 and 29: Treatment of Chronic HEV Reduction
- Page 30 and 31: Response to Antiviral Therapy Stool
- Page 34 and 35: Treatment of HEV: Future Therapy
- Page 36 and 37: Randomized trial in China, 112,604
Chronic <strong>Hepatitis</strong> E<br />
Other Immunosuppressed hosts<br />
■ Case reports in patients with non-Hodgkin lymphoma receiving rituximab<br />
and in patients with HIV infection. 1,2<br />
■ Low risk of acute HEV compared with the general population.<br />
■ Failure to clear HEV and consequently develop chronic infection. 3<br />
1.Ollier L, et al. Ann Intern Med 2009; 150:430.<br />
2.Dalton HR, et al. N Engl J Med 2009; 361:1025<br />
3.Goel A, Aggarwal R. Expert Rev Gastroenterol Hepatol 2016; 10:1065.
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