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Chronic <strong>Hepatitis</strong> E<br />
Solid organ transplants (kidney, liver, and kidney-pancreas) 1-3<br />
■ Exclusively in G3-infected individuals.<br />
■ A cohort of 700 solid organ Tx recipients, 34 (5%) acquired HEV infection,<br />
of whom 47% developed chronic infection. 3<br />
■ Impaired T-cell responses, lower counts of lymphocytes, CD4 T cells; use<br />
of FK; low platelet count; younger age; LTx.<br />
■ Natural history not understood, rapid progression to cirrhosis. 1<br />
■ Risk for HEV reactivation.<br />
1.Gérolami R, et al. N Engl J Med 2008; 358:859.<br />
2.Khuroo MS and Khuroo MS. Curr Opin Infect Dis 2008; 21:539.<br />
3.Legrand-Abravanel F, et al. Emerg Infect Dis 2011; 17:30.
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