Hepatitis E: What’s New?

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Chronic <strong>Hepatitis</strong> E Persistently elevated aminotransferase levels Detectable serum HEV RNA Histologic findings compatible with chronic viral hepatitis serum or stool HEV RNA> 6m Exclusively in context of solid organ transplantation, hematological disorders, immunosuppression(IS) or HIV
Chronic <strong>Hepatitis</strong> E Solid organ transplants (kidney, liver, and kidney-pancreas) 1-3 ■ Exclusively in G3-infected individuals. ■ A cohort of 700 solid organ Tx recipients, 34 (5%) acquired HEV infection, of whom 47% developed chronic infection. 3 ■ Impaired T-cell responses, lower counts of lymphocytes, CD4 T cells; use of FK; low platelet count; younger age; LTx. ■ Natural history not understood, rapid progression to cirrhosis. 1 ■ Risk for HEV reactivation. 1.Gérolami R, et al. N Engl J Med 2008; 358:859. 2.Khuroo MS and Khuroo MS. Curr Opin Infect Dis 2008; 21:539. 3.Legrand-Abravanel F, et al. Emerg Infect Dis 2011; 17:30.
Page 2 and 3: HEPATITIS E: WHAT’S NEW? Naglaa Z
Page 4 and 5: Known Facts: HEV ■ 20 million HEV
Page 6 and 7: Geographical Distribution of HEV Eg
Page 8 and 9: HEV Genotypes Four genotypes/24 sub
Page 10 and 11: Modes of HEV Transmission Fecal-ora
Page 12 and 13: Clinical Picture of HEV
Page 14 and 15: Complications of Acute HEV Acute Li
Page 16 and 17: Clinical Picture: Complications Acu
Page 20 and 21: Chronic Hepatitis E Other Immunosup
Page 22 and 23: Diagnostic tests for HEV IgM anti-H
Page 24 and 25: HEV Diagnosis Acute HEV Chronic HEV
Page 26 and 27: Treatment of HEV Acute HEV Signific
Page 28 and 29: Treatment of Chronic HEV Reduction
Page 30 and 31: Response to Antiviral Therapy Stool
Page 34 and 35: Treatment of HEV: Future Therapy
Page 36 and 37: Randomized trial in China, 112,604

Hepatitis E: What’s New?

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