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Clinical Picture: Complications<br />
Cholestatic <strong>Hepatitis</strong><br />
■ Prolonged cholestasis, protracted period of jaundice (>3 months), in up<br />
to 60% of patients with acute HEV.<br />
■ Asymptomatic or have symptoms of pruritus.<br />
■ Spontaneous resolution within weeks to months with no sequelae.<br />
■ Recovery is marked by viral clearance, an increase in IgG titers, and a<br />
decrease in IgM levels.<br />
Mechnik L, et al. J Clin Gastroenterol 2001; 33:421.<br />
Hoofnagle JH, et al. N Engl J Med 2012; 367:1237.
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