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HEV and Pregnancy<br />
In endemic regions<br />
■ Up to 70% of pregnant women progress to AHF in 2 nd & 3 rd trimester. 1<br />
■ Worse fetal and maternal outcomes.<br />
■ High mortality rate 15-25% in 3 rd trimester. 2<br />
■ HEV G-1 and 2, virulence of these human-specific viruses, hormonal and<br />
immunological changes.<br />
■ AHF and poor pregnancy outcomes not observed with G-3. 3,4<br />
1.Patra S, et al. Ann Intern Med 2007; 147:28. 2.Khuroo MS, et al. Am J Med 1981; 70:252.<br />
3.Anty R, et al. J Clin Virol 2012; 54:76. 4.Tabatabai J, et al. J Clin Virol 2014; 61:170.
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